ID A0A2K6AP42_MACNE Unreviewed; 463 AA.
AC A0A2K6AP42;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Centrosomal protein 57kDa-like protein 1 {ECO:0000256|ARBA:ARBA00041218};
DE AltName: Full=Cep57-related protein {ECO:0000256|ARBA:ARBA00042578};
GN Name=CEP57L1 {ECO:0000313|Ensembl:ENSMNEP00000000915.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000000915.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000000915.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000256|ARBA:ARBA00004300}.
CC -!- SIMILARITY: Belongs to the translokin family.
CC {ECO:0000256|ARBA:ARBA00008179}.
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DR AlphaFoldDB; A0A2K6AP42; -.
DR Ensembl; ENSMNET00000004781.1; ENSMNEP00000000915.1; ENSMNEG00000004205.1.
DR GeneTree; ENSGT00530000063695; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000004205; Expressed in cerebellum and 12 other cell types or tissues.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0043015; F:gamma-tubulin binding; IEA:InterPro.
DR GO; GO:0042802; F:identical protein binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR Gene3D; 1.20.58.90; -; 1.
DR InterPro; IPR025913; Cep57_CLD.
DR InterPro; IPR024957; Cep57_MT-bd_dom.
DR PANTHER; PTHR19336:SF10; CENTROSOMAL PROTEIN CEP57L1; 1.
DR PANTHER; PTHR19336; UNCHARACTERIZED DUF1167; 1.
DR Pfam; PF14073; Cep57_CLD; 1.
DR Pfam; PF06657; Cep57_MT_bd; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120}.
FT DOMAIN 57..234
FT /note="Cep57 centrosome localisation"
FT /evidence="ECO:0000259|Pfam:PF14073"
FT DOMAIN 316..387
FT /note="Cep57 centrosome microtubule-binding"
FT /evidence="ECO:0000259|Pfam:PF06657"
FT REGION 383..428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 55..117
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 192..219
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 323..357
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 394..428
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 463 AA; 53876 MW; 98AB01C272991AD1 CRC64;
MKIMDSELMH SIVGSYHKPP ERVFVPSFTQ NEPSQNCHPA NLEVTSSKIL HSPNSQALIL
ALKTLQEKIH HLELERTQAE DNLNILSREA AQYKKALENE TNERNLAHQE LIKQKKDISI
QLSSAQSRCT LLEKQLEYTK RMVLNVEREK NMILEQQAQL QREKEQDQIK LYAKLEKLDV
LEKECFRLTT TQKTAEDKIK HLEEKLKEEE HQRKLFQDKA SELQTGLEIS KIIMSSVSNL
KHSKEKKTSS KKTKCIKRGP PWQICSKFGA LPFVAEKRRQ HRGPHILQKP FNVAETRCLP
RPSRTTSWCK AIPRDSEKSI SICDNLSELL MAMQDELDQM SMEHQELLKQ MKETESHSVC
DDIECELECL VKKMEIKGEQ ISKLKKHQDS VRKLQQKVQN SKMSEASGIQ QEDSNPKGSK
NIKNSPRKCL TDTKLFQKNS SFHPIRVHNL QMKLRRDDIM WEQ
//
