ID   A0A2K6AP89_MACNE        Unreviewed;      1302 AA.
AC   A0A2K6AP89;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   SubName: Full=Rho guanine nucleotide exchange factor 10 {ECO:0000313|Ensembl:ENSMNEP00000000965.1};
GN   Name=ARHGEF10 {ECO:0000313|Ensembl:ENSMNEP00000000965.1};
OS   Macaca nemestrina (Pig-tailed macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000000965.1, ECO:0000313|Proteomes:UP000233120};
RN   [1] {ECO:0000313|Ensembl:ENSMNEP00000000965.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   Ensembl; ENSMNET00000005087.1; ENSMNEP00000000965.1; ENSMNEG00000004461.1.
DR   GeneTree; ENSGT00940000153798; -.
DR   Proteomes; UP000233120; Unplaced.
DR   Bgee; ENSMNEG00000004461; Expressed in lung and 12 other cell types or tissues.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   InterPro; IPR039919; ARHGEF10/ARHGEF17.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR12877; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR12877:SF14; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 10; 1.
DR   Pfam; PF19057; PH_19; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   Pfam; PF19056; WD40_2; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS50010; DH_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233120}.
FT   DOMAIN          389..576
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   REGION          1..69
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          148..236
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1159..1193
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1210..1235
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          272..323
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          559..590
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        1..16
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1159..1181
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1210..1228
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1302 AA;  144239 MW;  3643A4F862FA8799 CRC64;
     LPSRENEMKY DTNNNEEEEG EQFDFDSGDE IPEADRQAPS APETGGAGAS EAPAPTGGED
     GAGAETTPVV EPAKLVLPVK VNPYSVIDIA PFQEDQPPAP APSTEEESVG LHVPCGYSVP
     VPCGYAVPSN LPLLLPAYSS PVIIRATSLD EEAETPEVME DRQPNSLSSE EPPNSEDQVS
     REDSALARWA ADPANTAWME NPEEAIYDDV PRENSDSEPD EMIYDDVENG DEGGNSSLEY
     GWSSSEFESY EEQSDSECKN GIPRSFLRSN HKKQLSHDLT RLKEHYEKKM RELMASTVGA
     VEIQQLRQKH ELKMQKLVKA AKDGTKDGLE RTRAAVKRGR SFIRTKSLIA QDHRSSLEEE
     QNLFIDVDCK HPEAILTPMP EGLSQQQVVR RYILGSVVDS EKNYVDALKR ILEQYEKPLS
     EMEPKFLSER KLKTVFYRVK EILQCHSLFQ IALASRVSEW DSVEMIGDVF VASFSKSMVL
     DAYSEYVNNF STAVAVLKKT CATKPAFLEF LKQEQEASPD RTTLYSLMMK PIQRFPQFIL
     LLQDMLKNTS KGHPDRLPLQ MALTELETLA EKLNERKRDA DQRCEVKQIA KAINERYLNK
     LLSSGSRYLI RSDDMIETVY NDRGEIVKTK ERRVFMLNDV LMCATVSSRA SHDSRVMSSQ
     RYLLKWSVPL GHVDAIEYGS SPGAGEHSRH LAVHPPESLA VVANAKPNKV YMGPGQLYQD
     LQNLLHDLNV IGQITQLIGN LKGNYQNLNQ SVAHDWTSGL QRLILKKEDE IRAADCCRIQ
     LQLPGKQDKL VVALKRNLLE EENHMGWFCV EDDGNHIKKE KHPLLVGHMP VMVAKQQEFK
     IECAAYNPEP YLNNESQPDS FSTAHGFLWI GSCTHQMGQI AIVSFQNSTP KVIECFNVES
     RILCMLYIPV EEKRREPGAP LDPETPAVRA SEVPTICGVL TALQRISAKK VRLQHFFTPE
     KSTVMSLACT SQSLYAGLVN GAVANGSWDS EPQKVIKLGV LPVRSLLMME DTLWAASGGQ
     VFIISVETRA VEGQLEAHQE EGMVISHMAV AGVGIWIAFT SGSTLRLFHT ETLKHLQDIN
     IATPVHNMLP GHQRLSVTSL LVCHGLLMVG TSLGVLVALP VPRLQGIPKV TGRGMVSYHA
     HNGPVKFIIL ATALHEKDKD KSGDGLAPGP EPQDEDQKDA LPSEGTGSSL NQGDADTAIW
     LGDSLGSMTQ KSDVSSSSGS LSLSHGSSSL EHRSEDSTIC DLLKDPVSLR SKARRAKKAK
     ASSALVVCGG QGHRRVHRKA RQPHQEELAP SVMVWQIPLL NI
//