ID A0A2K6AQ64_MACNE Unreviewed; 277 AA.
AC A0A2K6AQ64;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=TNF alpha induced protein 6 {ECO:0000313|Ensembl:ENSMNEP00000001294.1};
GN Name=TNFAIP6 {ECO:0000313|Ensembl:ENSMNEP00000001294.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000001294.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000001294.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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DR RefSeq; XP_011758208.1; XM_011759906.1.
DR AlphaFoldDB; A0A2K6AQ64; -.
DR SMR; A0A2K6AQ64; -.
DR STRING; 9545.ENSMNEP00000001294; -.
DR Ensembl; ENSMNET00000006351.1; ENSMNEP00000001294.1; ENSMNEG00000005810.1.
DR GeneID; 105492665; -.
DR KEGG; mni:105492665; -.
DR CTD; 7130; -.
DR GeneTree; ENSGT00940000157201; -.
DR OMA; WGFRNGI; -.
DR OrthoDB; 3019692at2759; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000005810; Expressed in bone marrow and 7 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:Ensembl.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0106435; F:carboxylesterase activity; IEA:Ensembl.
DR GO; GO:0001968; F:fibronectin binding; IEA:Ensembl.
DR GO; GO:0005540; F:hyaluronic acid binding; IEA:Ensembl.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR GO; GO:1905590; P:fibronectin fibril organization; IEA:Ensembl.
DR GO; GO:0030212; P:hyaluronan metabolic process; IEA:Ensembl.
DR GO; GO:0030514; P:negative regulation of BMP signaling pathway; IEA:Ensembl.
DR GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl.
DR GO; GO:0090024; P:negative regulation of neutrophil chemotaxis; IEA:Ensembl.
DR GO; GO:0045668; P:negative regulation of osteoblast differentiation; IEA:Ensembl.
DR GO; GO:0045671; P:negative regulation of osteoclast differentiation; IEA:Ensembl.
DR GO; GO:0001550; P:ovarian cumulus expansion; IEA:Ensembl.
DR GO; GO:1903911; P:positive regulation of receptor clustering; IEA:Ensembl.
DR CDD; cd00041; CUB; 1.
DR CDD; cd03515; Link_domain_TSG_6_like; 1.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR000538; Link_dom.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR46908; CUBILIN-LIKE PROTEIN; 1.
DR PANTHER; PTHR46908:SF8; TUMOR NECROSIS FACTOR-INDUCIBLE GENE 6 PROTEIN; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF00193; Xlink; 1.
DR PRINTS; PR01265; LINKMODULE.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00445; LINK; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS01241; LINK_1; 1.
DR PROSITE; PS50963; LINK_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00323}; Lectin {ECO:0000256|ARBA:ARBA00022734};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..277
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014323543"
FT DOMAIN 36..129
FT /note="Link"
FT /evidence="ECO:0000259|PROSITE:PS50963"
FT DOMAIN 135..247
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DISULFID 58..127
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00323"
FT DISULFID 82..103
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00323"
SQ SEQUENCE 277 AA; 31057 MW; DA34E36D941FF845 CRC64;
MIILIYLFLL LWEEAQGWGF KDGIFHNSIW LERAAGVYHR ESRSGKYKLT YAEAKAVCEF
EGGHLATYKQ LEAARKIGFH VCAAGWMAKG RVGYPIVKPG PNCGFGKTGI IDYGVRLNRS
ERWDAYCYNP HAKECGGVFT DSKGIFKSPG FPNEYEDNQI CYWHIRLKYG QHIHLSFLDF
DLEDDPGCLA DYVEIYDSYD DVHGFVGRYC GDELPDDIIS TGNVMTLKFL SDASVTAGGF
QIKYVAVDPV SKSSQGKNTS TTSTGNKNFL AGRFSHL
//
