ID A0A2K6AQF9_MACNE Unreviewed; 580 AA.
AC A0A2K6AQF9;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Acetylserotonin O-methyltransferase like {ECO:0000313|Ensembl:ENSMNEP00000001383.1};
GN Name=ASMTL {ECO:0000313|Ensembl:ENSMNEP00000001383.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000001383.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000001383.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC Evidence={ECO:0000256|ARBA:ARBA00001968};
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DR AlphaFoldDB; A0A2K6AQF9; -.
DR Ensembl; ENSMNET00000006699.1; ENSMNEP00000001383.1; ENSMNEG00000006097.1.
DR GeneTree; ENSGT00940000162413; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000006097; Expressed in heart and 12 other cell types or tissues.
DR GO; GO:0047429; F:nucleoside triphosphate diphosphatase activity; IEA:InterPro.
DR GO; GO:0008171; F:O-methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd00555; Maf; 1.
DR Gene3D; 3.90.950.10; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR HAMAP; MF_00528; Maf; 1.
DR InterPro; IPR031725; ASMT_dimerisation.
DR InterPro; IPR016461; COMT-like.
DR InterPro; IPR029001; ITPase-like_fam.
DR InterPro; IPR003697; Maf-like.
DR InterPro; IPR001077; O_MeTrfase_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00172; maf; 1.
DR PANTHER; PTHR43213; BIFUNCTIONAL DTTP/UTP PYROPHOSPHATASE/METHYLTRANSFERASE PROTEIN-RELATED; 1.
DR PANTHER; PTHR43213:SF5; BIFUNCTIONAL DTTP_UTP PYROPHOSPHATASE_METHYLTRANSFERASE PROTEIN-RELATED; 1.
DR Pfam; PF16864; Dimerisation2; 1.
DR Pfam; PF02545; Maf; 1.
DR Pfam; PF00891; Methyltransf_2; 1.
DR SUPFAM; SSF52972; ITPase-like; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51683; SAM_OMT_II; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022603}.
FT DOMAIN 288..370
FT /note="Acetylserotonin O-methyltransferase dimerisation"
FT /evidence="ECO:0000259|Pfam:PF16864"
FT DOMAIN 388..508
FT /note="O-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00891"
FT REGION 235..276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 580 AA; 64316 MW; EE47AC371F6FBB62 CRC64;
MVLCPVIGKL LHKRVVLASA SPRRQEILSN AGLRFEVVPS RFKEKLDKAS FATPYGYAME
TAKQKALEVA TRMHQKDLRT PDVVIGADTI VTVGGLILEK PVDKQDAYRM LSRLSGKEHS
VFTGVAIVHC SSNDRQLHTR VSEFYEETTV KFSELSEELL WEYIHSGEPM DKAGGYGIQA
LGGMLVESVH GDFLNVVGFP LNHFCKQLVE LYYPPRPEDL RQPVQHDSIP AVDTFEDLSD
VEGGGSEPAQ RETGSRDEKA EVGAAGRATA EAECHRTRAT LPPFPTRLLE LLDGFKLSKA
LLTACKLKVF DWLKREAPQK APDIASKVDA SACGTEKLLD VCAAMGLLEK TEQGYSNTET
ANLYLASDSE YSLHGFMLQN NDVIWNLFTY LEFAIREGRN QHHRVLGKKV EDLFQDAYYR
SPETQLRFMQ AMHGMAKLTA RQVATAFDLS RFSSACDVGG CTGALARELA REYPRLQVTV
FDLPDVVELA VHFQPAGPQA AQIHFAAGTG LLLVETLLDE EKREAQGGLI QSLNTLVQTE
GRERSRGEYQ CLLELHGFHQ VQVVHLEGVL DAMLATRVAP
//
