ID A0A2K6AQL4_MACNE Unreviewed; 354 AA.
AC A0A2K6AQL4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Major histocompatibility complex, class I, G {ECO:0000313|Ensembl:ENSMNEP00000001438.1};
GN Name=HLA-G {ECO:0000313|Ensembl:ENSMNEP00000001438.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000001438.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000001438.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the MHC class I family.
CC {ECO:0000256|RuleBase:RU004439}.
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DR AlphaFoldDB; A0A2K6AQL4; -.
DR STRING; 9545.ENSMNEP00000001438; -.
DR Ensembl; ENSMNET00000007019.1; ENSMNEP00000001438.1; ENSMNEG00000006424.1.
DR GeneTree; ENSGT00980000198488; -.
DR OMA; YRCHVDH; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000006424; Expressed in skeletal muscle tissue and 3 other cell types or tissues.
DR GO; GO:0033106; C:cis-Golgi network membrane; IEA:Ensembl.
DR GO; GO:0005769; C:early endosome; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0042610; F:CD8 receptor binding; IEA:Ensembl.
DR GO; GO:0042605; F:peptide antigen binding; IEA:Ensembl.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0002476; P:antigen processing and presentation of endogenous peptide antigen via MHC class Ib; IEA:Ensembl.
DR GO; GO:0002767; P:immune response-inhibiting cell surface receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0016525; P:negative regulation of angiogenesis; IEA:Ensembl.
DR GO; GO:2001199; P:negative regulation of dendritic cell differentiation; IEA:Ensembl.
DR GO; GO:0070317; P:negative regulation of G0 to G1 transition; IEA:Ensembl.
DR GO; GO:0051898; P:negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl.
DR GO; GO:0001915; P:negative regulation of T cell mediated cytotoxicity; IEA:Ensembl.
DR GO; GO:0042130; P:negative regulation of T cell proliferation; IEA:Ensembl.
DR GO; GO:0002451; P:peripheral B cell tolerance induction; IEA:Ensembl.
DR GO; GO:2000774; P:positive regulation of cellular senescence; IEA:Ensembl.
DR GO; GO:2000353; P:positive regulation of endothelial cell apoptotic process; IEA:Ensembl.
DR GO; GO:0032735; P:positive regulation of interleukin-12 production; IEA:Ensembl.
DR GO; GO:0060907; P:positive regulation of macrophage cytokine production; IEA:Ensembl.
DR GO; GO:0002729; P:positive regulation of natural killer cell cytokine production; IEA:Ensembl.
DR GO; GO:0045591; P:positive regulation of regulatory T cell differentiation; IEA:Ensembl.
DR GO; GO:0002666; P:positive regulation of T cell tolerance induction; IEA:Ensembl.
DR GO; GO:0042270; P:protection from natural killer cell mediated cytotoxicity; IEA:Ensembl.
DR GO; GO:0070207; P:protein homotrimerization; IEA:Ensembl.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.30.500.10; MHC class I-like antigen recognition-like; 1.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR011161; MHC_I-like_Ag-recog.
DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf.
DR InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR InterPro; IPR001039; MHC_I_a_a1/a2.
DR PANTHER; PTHR16675:SF169; HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, ALPHA CHAIN G; 1.
DR PANTHER; PTHR16675; MHC CLASS I-RELATED; 1.
DR Pfam; PF00129; MHC_I; 1.
DR PRINTS; PR01638; MHCCLASSI.
DR SMART; SM00407; IGc1; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF54452; MHC antigen-recognition domain; 1.
DR PROSITE; PS00290; IG_MHC; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..354
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014323589"
FT TRANSMEM 277..303
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 205..264
FT /note="Immunoglobulin C1-set"
FT /evidence="ECO:0000259|SMART:SM00407"
SQ SEQUENCE 354 AA; 40289 MW; 312502DEF3EBCE27 CRC64;
MVTPRMVVMA PRTLLLLLSG ALALTETWAG SHSMRYFSAP GRGEPRFIPV GYVDYTQFVW
LDSYAASLRM EPRGPWVEQE RPEYWEEQTR IAKAHAQTDR VNQRTLRSCY NQSEAGYHTL
QWMIGCDLGP DGRLFRCEQF DYLALKEDLP DTVAQISKRK CEAAKVTERR RAYLEGTYLE
NGKEMLHRAD PPNSHVTHHP VFDYEATLRL TWQRESEDQT HDVELVGTRP AGDGTFQKWA
AVVVPSGEEQ RFMCYVQHQG LPSPSPPFPE QSFQPTILIM GIIAGLVVFA AVVTEAVVTF
VLWRKKSSEF FCPTEGSKPQ VEMPCLVTGK HHLHSWADPA YALCASTYSF VKHM
//
