ID A0A2K6AQZ7_MACNE Unreviewed; 2636 AA.
AC A0A2K6AQZ7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Serine/threonine-protein kinase ATR {ECO:0000256|ARBA:ARBA00024420};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=ATR {ECO:0000313|Ensembl:ENSMNEP00000001577.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000001577.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000001577.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. ATM subfamily.
CC {ECO:0000256|ARBA:ARBA00010769}.
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DR Ensembl; ENSMNET00000007741.1; ENSMNEP00000001577.1; ENSMNEG00000006874.1.
DR GeneTree; ENSGT00940000155714; -.
DR OMA; SMYIGWC; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000006874; Expressed in thymus and 12 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0048584; P:positive regulation of response to stimulus; IEA:UniProt.
DR GO; GO:0080135; P:regulation of cellular response to stress; IEA:UniProt.
DR GO; GO:0060255; P:regulation of macromolecule metabolic process; IEA:UniProt.
DR GO; GO:0051171; P:regulation of nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0080090; P:regulation of primary metabolic process; IEA:UniProt.
DR CDD; cd00892; PIKKc_ATR; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR012993; UME.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF128; SERINE_THREONINE-PROTEIN KINASE ATR; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF08064; UME; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SMART; SM00802; UME; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00023204};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT REPEAT 797..831
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT DOMAIN 1632..2177
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 2288..2596
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 2604..2636
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 411..441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 411..436
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2636 AA; 300743 MW; C48B2185418C70FE CRC64;
RGELKAFNLY FSATPEEYNA VVQKPRQILC QFIDRILTDV NVVAVELVKK TDSQPTSVML
LDFIQHIMKS SPLMFVNVNG SHEAKGSCIE FSNWIITRLL RIAATPSCHL LHKKICEVIC
SLLFLFKSKS PAIFGVLTKE LLQLFEDLVY LHRRNVMGHA VEWPVVISRF LSQLDEHMGY
LQSAPLRLIS MQNLEFIEVT LLTVLTRIIA IVFFRRQELL LWQIGCVLLE YGSPKIKSLA
ISFLTELFQL GGLPAQPAST FFSSFLELLK HLVEMDTDQL KLYEEPLSKL IKTLFPFEAE
AYRNIEPVYL NMLLEKLCVM FEDGVLMRLK SDLLKAALCH LLQYFLKFVP AGYESALQVR
KVYVTNICKA LLDVLGIQVD AEYLLGPLYA ALKVESMEII EEIQCQTQQE NLSSNSDGIS
PKRRRLSSSL NPSKRAPKQT EEIKHVNMNQ KSVLWSALKQ KAESLQISLE YSGLKNPVIE
MLEGIAVVLQ LTALCTVHCS HQNMNCPTFK DCQHKSKKKP SVVITWMSLD FYTKVLKSCR
SLLETVQKPD LEATIDKVVK IYDALIYMQV NSSFEDHILE DLCGMLSLPW IYSHSDDGCL
KLTTFATNLL TLSHRISDSY SPQAQSRCVF LLTLFPRRIF LEWRTAVYNW ALQSSHEVIR
ASCVSGFFIL LQQQNSCNRV PKILIDKVKD DSDIIKKEFA SILGQLVCTL HGMFYLTSSL
TEPFSEHEHV DLFCRNLKAT SQHECSSSQL KASVCKPFLF LLKKKTPSAV KLAFIDNLHH
LCKHLDFRED ETDVKAVLGT LLNLMEDPDK DVRVAFSGNI KHILESLDSE DGFIKELFVL
RMKEAYTHAQ ISRDYELKDT LILTTGDIGR AAKGDLVPFA LLHLLHCLLS KSASVSGAAY
TEIRALVAAK SVKLQNFFSQ YKKPICQFLV ESLHSSQMTA LPSTPCQNAD MRKQDVAHQR
EMALNTLSEI ANVFDFPDLN RFLTRTLQVL LPDLAAKASP AASALIRTLG KQLNVNRREI
LINNFKYIFS HLVCSCSKDE LERALHYLKN ETEIELGSLL RQDFQGLHNE LLLRIGEHYQ
QVFNGLSILA SFASSDDPYQ GPRDIISPEL MADYLQPKLL GILAFFNMQL LSSSVGIEDK
KMALNSLMSL MKLMGPKHVS SVRVKMMTTL RTGLRFKDDF PELCCRAWDC FVRCLDHACL
GSLLSHVIVA LLPLIHIQPK ETAAIFHYLI IENRDAVQDF LHEIYFLPDH PELKKIKAIL
QEYRKETSES TDLQTTLQLS MKAIQHENVD VRIHALTSLK ETLYKNQEKL IKYATDSETV
EPIISQLVTV LLKGCQDANS QARLLCGECL GELGAIDPGR LDFSTTETQG KDFTFVTGVE
DSSFAYGLLM ELTRAYLAYA DNSRAQDSAA YAIQELLSIY DCREMETNGP GHQLWRRFPE
HVREILEPHL NTRYKSSQKS TDWSGVKKPI YLSKLGSNFA EWSASWAGYL ITKVRHDLAS
KIFTCCSIMM KHDFKVTIYL LPHILVYVLL GCNQEDQQEV YAEIMAVLKH DDQHTINTQD
IASDLCQLST QTVFSMLDHL TQWARHKFQA LKAEKCPHSK SNRNKVDSLV STVDYEDYQS
VTRFLDLIPQ DTLAVASFRS KAYTRAVMHF ESFITEKKQN IQEHLGFLQK LYAAMHEPDG
VAGVSAIRKA EPSLKEQILE HESLGLLRDA TACYDRAIQL EPDQIIHYHG VVKSMLGLGQ
LSTVITQVNG VHANRSEWTD ELNTYRVEAA WKLSQWDLVE NYLAADGKST TWSVRLGQLL
LSAKKRDITA FYDTLKLVRA EQIVPLSAAS FERGSYQRGY EYIVRLHMLC ELEHSIKPLF
QHSPGDSSQE DSLNWVARLE MTQNSYRAKE PILALRRALL SLNKRPDHDE MVGECWLQSA
RVARKAGHHQ TAYNALLNAG ESRLAELYVE RAKWLWSKGD VHQALIVLQK GVELCFPENE
TPPEGKNMLI HGRAMLLVGR FMEETANFES NAIMKKYKDV TACLPEWEDG HFYLAKYYDK
LMPMVTDNKM EKQGDLIRYI VLHFGRSLQY GNQFIYQSMP RMLTLWLDYG TKAYEWEKAG
RSDRVQMRND LGKINKVITE HTNYLAPYQF LTAFSQLISR ICHSHDEVFV VLMEIIAKVF
LAYPQQAMWM MTAVSKSSYP MRVNRCKEIL NKAIHMKKSL EKFVGDATRL TDKLLELCNK
PVDGSSSTLS MRTHFKMLKK LVEEATFSEI LIPLQSVMIP TLPSILGTHA NHASHEPFPG
HWAYIAGFDD MVEILASLQK PKKISLKGSD GKFYIMMCKP KDDLRKDCRL MEFNSLINKC
LRKDAESRRR ELHIRTYAVI PLNDECGIIE WVNNTAGLRP ILTKLYKEKG VYMTGKELRQ
CMLPKSAALS EKLKVFREFL LPRHPPIFHE WFLRTFPDPT SWYSSRSAYC RSTAVMSMVG
YILGLGDRHG ENILFDSLTG ECVHVDFNCL FNKGETFEVP EIVPFRLTHN MVNGMGPMGT
EGLFRRACEV TMRLMRDQRE PLMSVLKTFL HDPLVEWSKP VKGHSKAPLN ETGEVVNEKA
KTHVLDIEQR LQGVIKTRNR VTGLPLSIEG HVHYLIQEAT DENLLCQMYL GWTPYM
//
