ID A0A2K6ASZ0_MACNE Unreviewed; 224 AA.
AC A0A2K6ASZ0;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Dickkopf WNT signaling pathway inhibitor 4 {ECO:0000313|Ensembl:ENSMNEP00000002266.1};
GN Name=DKK4 {ECO:0000313|Ensembl:ENSMNEP00000002266.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000002266.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000002266.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the dickkopf family.
CC {ECO:0000256|ARBA:ARBA00010842}.
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DR RefSeq; XP_011730812.1; XM_011732510.1.
DR RefSeq; XP_011730813.1; XM_011732511.1.
DR AlphaFoldDB; A0A2K6ASZ0; -.
DR STRING; 9545.ENSMNEP00000002266; -.
DR Ensembl; ENSMNET00000011364.1; ENSMNEP00000002266.1; ENSMNEG00000010449.1.
DR GeneID; 105476524; -.
DR KEGG; mni:105476524; -.
DR CTD; 27121; -.
DR GeneTree; ENSGT00940000161614; -.
DR OMA; QRSAMCC; -.
DR OrthoDB; 4329885at2759; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000010449; Expressed in skeletal muscle tissue and 1 other cell type or tissue.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0061170; P:negative regulation of hair follicle placode formation; IEA:Ensembl.
DR GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IEA:InterPro.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:Ensembl.
DR CDD; cd23013; Dkk4_Cys1; 1.
DR CDD; cd23275; Dkk4_Cys2; 1.
DR Gene3D; 2.10.80.10; Lipase, subunit A; 1.
DR InterPro; IPR006796; Dickkopf_N.
DR InterPro; IPR048500; DIKK1/2/4_C-subdom1.
DR InterPro; IPR048499; DIKK1/2/4_C-subdom2.
DR InterPro; IPR039863; DKK1-4.
DR InterPro; IPR047299; Dkk4_Cys2.
DR PANTHER; PTHR12113:SF10; DICKKOPF-RELATED PROTEIN 4; 1.
DR PANTHER; PTHR12113; DICKKOPF3-LIKE 3; 1.
DR Pfam; PF04706; Dickkopf_N; 1.
DR Pfam; PF21481; DIKK1-2-4_C-subdom1; 1.
DR Pfam; PF21479; DIKK1-2-4_C-subdom2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..224
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014348798"
FT DOMAIN 40..91
FT /note="Dickkopf N-terminal cysteine-rich"
FT /evidence="ECO:0000259|Pfam:PF04706"
FT DOMAIN 141..170
FT /note="Dickkopf-related protein 1/2/4 C-terminal subdomain
FT 1"
FT /evidence="ECO:0000259|Pfam:PF21481"
FT DOMAIN 173..220
FT /note="Dickkopf-related protein 1/2/4 C-terminal subdomain
FT 2"
FT /evidence="ECO:0000259|Pfam:PF21479"
FT REGION 114..139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 125..139
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 224 AA; 25027 MW; 5C85DF4C254140B3 CRC64;
MAAAVLLGLS WLCSPLGALV LDFNNIRSSA DLLGARKGSQ CLSDTDCNTR KFCLQSHNEK
PFCATCRGLQ RRCQRDAMCC PGTLCMNDVC TTMEDATPKW ERQLDEQDGT HAEVTTGHPV
QENQPKRKPS IKKSQGRKRQ EGESCLRTFD CGPGLCCARH FWTKICKPVL LEGQVCSRRG
HKDTAQAPEI FQRCDCGPGL LCRSQLTSNR QHARLRVCQK IEKL
//
