ID   A0A2K6ATY0_MACNE        Unreviewed;       908 AA.
AC   A0A2K6ATY0;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Sorting nexin 14 {ECO:0000313|Ensembl:ENSMNEP00000002602.1};
GN   Name=SNX14 {ECO:0000313|Ensembl:ENSMNEP00000002602.1};
OS   Macaca nemestrina (Pig-tailed macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000002602.1, ECO:0000313|Proteomes:UP000233120};
RN   [1] {ECO:0000313|Ensembl:ENSMNEP00000002602.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the sorting nexin family.
CC       {ECO:0000256|ARBA:ARBA00010883}.
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DR   AlphaFoldDB; A0A2K6ATY0; -.
DR   Ensembl; ENSMNET00000013242.1; ENSMNEP00000002602.1; ENSMNEG00000011232.1.
DR   GeneTree; ENSGT00950000182856; -.
DR   Proteomes; UP000233120; Unplaced.
DR   Bgee; ENSMNEG00000011232; Expressed in cerebellum and 12 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; IEA:InterPro.
DR   CDD; cd06877; PX_SNX14; 1.
DR   CDD; cd08722; RGS_SNX14; 1.
DR   Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR   Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR   InterPro; IPR003114; Phox_assoc.
DR   InterPro; IPR001683; PX_dom.
DR   InterPro; IPR036871; PX_dom_sf.
DR   InterPro; IPR016137; RGS.
DR   InterPro; IPR036305; RGS_sf.
DR   InterPro; IPR044926; RGS_subdomain_2.
DR   InterPro; IPR037436; SNX14_PX.
DR   InterPro; IPR037892; SNX14_RGS.
DR   InterPro; IPR013937; Sorting_nexin_C.
DR   PANTHER; PTHR22775; SORTING NEXIN; 1.
DR   PANTHER; PTHR22775:SF44; SORTING NEXIN-14; 1.
DR   Pfam; PF08628; Nexin_C; 1.
DR   Pfam; PF00787; PX; 1.
DR   Pfam; PF02194; PXA; 1.
DR   Pfam; PF00615; RGS; 1.
DR   SMART; SM00312; PX; 1.
DR   SMART; SM00313; PXA; 1.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF64268; PX domain; 1.
DR   SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR   PROSITE; PS50195; PX; 1.
DR   PROSITE; PS51207; PXA; 1.
DR   PROSITE; PS50132; RGS; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        51..68
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        75..94
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          107..283
FT                   /note="PXA"
FT                   /evidence="ECO:0000259|PROSITE:PS51207"
FT   DOMAIN          315..447
FT                   /note="RGS"
FT                   /evidence="ECO:0000259|PROSITE:PS50132"
FT   DOMAIN          540..660
FT                   /note="PX"
FT                   /evidence="ECO:0000259|PROSITE:PS50195"
SQ   SEQUENCE   908 AA;  105110 MW;  130E74AF7350C273 CRC64;
     FPADSTGSGC PSGSRNLGLA VTEMMPWVRT IGEKLKQRLR LDVGREICRQ YPLFCFLLLC
     LSVASLLLNR YIHILMIFWS FVAGVVTFYC SLGPDSLLPN IFFTIKYKPK QLGLQELFPQ
     GHSCAVCGKV KCKRHRPSLL LENYQPWLDL KISSKVDASL SEVDIPSIIT KKLLKAAMKH
     IEVIVKARQK VKNTEFLQQA ALEEYGPELH VALRSRRDEL HYLRKLTELL FPYILPPKAT
     DCRSLTLLLR EILSGSVFLP SLDFLADPDT VNHLLIIFID DSPPEKATEP ASPLVPFLQK
     FAEPRNKKPS VLKLELKQIR EQQDLLFRFM NFLKQEGAVH VLQFCLTVEE FNDRILRPEL
     SNDEMLSLHE ELQKIYKTYC LDESIDKIRF DPFIVEEIQR IAEGPYIDVV KLQTMRCLFE
     AYEHVLSLLE NVFTPMFCHS DEYFRQLLRG AESPTRNSKF NRNTQKRGES FGISRIGSKI
     KGVFKSTTME GAMLPNYGVA EGEDDFIEEG IVVMEDDSPV EAVSTPNTPR NLAAWKISIP
     YVDFFEDPSS ERKEKKERIP VFCIDVERND RRAVGHEPEH WSVYRRYLEF YVLESKLTEF
     HGTFPDAQLP SKRIIGPKNY EFLKSKREEF QEYLQKLLQH PELSNSQLLA DFLSPNGGET
     QFLDKILPDV NLGKIIKSVP GKLMKEKGQH LEPFIMNFIN SCESPKPKPS RPELTILSPT
     SENNKKLFND LFKNNANRAE NTERKQNQNY FMEVMTVEGV YDYLMYVGRV VFQVPDWLHH
     LLMGTRILFK NTLEMYTDYY LQCKLEQLFQ EHRLVSLITL LRDAIFCENT EPRSLQDKQK
     GAKQTFEEMM NYIPDLLVKC IGEETKYESI RLLFDGLQQP VLNKQVKHIK ADKLVLVQKE
     VTSVTSWM
//