ID A0A2K6AU30_MACNE Unreviewed; 372 AA.
AC A0A2K6AU30;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=T-box transcription factor 1 {ECO:0000313|Ensembl:ENSMNEP00000002648.1};
GN Name=TBX1 {ECO:0000313|Ensembl:ENSMNEP00000002648.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000002648.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000002648.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00201}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00201}.
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DR AlphaFoldDB; A0A2K6AU30; -.
DR Ensembl; ENSMNET00000013452.1; ENSMNEP00000002648.1; ENSMNEG00000012296.1.
DR GeneTree; ENSGT00940000154816; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000012296; Expressed in skeletal muscle tissue and 1 other cell type or tissue.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd20187; T-box_TBX1_10-like; 1.
DR Gene3D; 2.60.40.820; Transcription factor, T-box; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR046360; T-box_DNA-bd.
DR InterPro; IPR036960; T-box_sf.
DR InterPro; IPR001699; TF_T-box.
DR InterPro; IPR018186; TF_T-box_CS.
DR PANTHER; PTHR11267; T-BOX PROTEIN-RELATED; 1.
DR PANTHER; PTHR11267:SF104; T-BOX TRANSCRIPTION FACTOR TBX1; 1.
DR Pfam; PF00907; T-box; 1.
DR PRINTS; PR00937; TBOX.
DR SMART; SM00425; TBOX; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS01283; TBOX_1; 1.
DR PROSITE; PS01264; TBOX_2; 1.
DR PROSITE; PS50252; TBOX_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00201};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00201}; Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 96..279
FT /note="T-box"
FT /evidence="ECO:0000259|PROSITE:PS50252"
FT REGION 1..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 304..338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..51
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 319..338
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 372 AA; 40656 MW; ACED276AA25108BD CRC64;
MHFSTVTRDM EGEPLGRVYT GPPARSPASA AMGPTVAPPP PGAPARRPPH AYPFAPAAGA
ATSAAAEPEG PGASCAAAAK APVKKNAKVA GVSVQLEMKA LWDEFNQLGT EMIVTKAGRR
MFPTFQVKLF GMDPMADYML LMDFVPVDDK RYRYAFHSSS WLVAGKADPA TPGRVHYHPD
SPAKGAQWMK QIVSFDKLKL TNNLLDDNGH IILNSMHRYQ PRFHVVYVDP RKDSEKYAEE
NFKTFVFEET RFTAVTAYQN HRITQLKIAS NPFAKGFRDC DPEDWPRNHR PGALPLMSAF
ARSRNPVASP TQPSGAEKGR AGVKKKKKAE TSRNAPERAV ELLRDAGGCV NLGLPCPAEC
QPFNTQGLVA GR
//
