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Database: UniProt
Entry: A0A2K6AX12_MACNE
LinkDB: A0A2K6AX12_MACNE
Original site: A0A2K6AX12_MACNE 
ID   A0A2K6AX12_MACNE        Unreviewed;       345 AA.
AC   A0A2K6AX12;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 29.
DE   SubName: Full=Transducer of ERBB2, 1 {ECO:0000313|Ensembl:ENSMNEP00000003701.1};
GN   Name=TOB1 {ECO:0000313|Ensembl:ENSMNEP00000003701.1};
OS   Macaca nemestrina (Pig-tailed macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000003701.1, ECO:0000313|Proteomes:UP000233120};
RN   [1] {ECO:0000313|Ensembl:ENSMNEP00000003701.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the BTG family. {ECO:0000256|ARBA:ARBA00007989}.
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DR   RefSeq; XP_011723908.1; XM_011725606.1.
DR   AlphaFoldDB; A0A2K6AX12; -.
DR   SMR; A0A2K6AX12; -.
DR   STRING; 9545.ENSMNEP00000003701; -.
DR   Ensembl; ENSMNET00000018895.1; ENSMNEP00000003701.1; ENSMNEG00000017321.1.
DR   GeneID; 105472397; -.
DR   KEGG; mni:105472397; -.
DR   CTD; 10140; -.
DR   GeneTree; ENSGT00940000154208; -.
DR   OMA; FPNVQGQ; -.
DR   OrthoDB; 11568at2759; -.
DR   Proteomes; UP000233120; Unplaced.
DR   Bgee; ENSMNEG00000017321; Expressed in skeletal muscle tissue and 12 other cell types or tissues.
DR   GO; GO:0030014; C:CCR4-NOT complex; IEA:Ensembl.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0030971; F:receptor tyrosine kinase binding; IEA:Ensembl.
DR   GO; GO:0046332; F:SMAD binding; IEA:Ensembl.
DR   GO; GO:0003714; F:transcription corepressor activity; IEA:Ensembl.
DR   GO; GO:0030514; P:negative regulation of BMP signaling pathway; IEA:Ensembl.
DR   GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR   GO; GO:0060212; P:negative regulation of nuclear-transcribed mRNA poly(A) tail shortening; IEA:Ensembl.
DR   GO; GO:0045668; P:negative regulation of osteoblast differentiation; IEA:Ensembl.
DR   GO; GO:0017148; P:negative regulation of translation; IEA:Ensembl.
DR   GO; GO:1900153; P:positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; IEA:Ensembl.
DR   GO; GO:0060213; P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; IEA:Ensembl.
DR   GO; GO:0060390; P:regulation of SMAD protein signal transduction; IEA:Ensembl.
DR   Gene3D; 3.90.640.90; Anti-proliferative protein, N-terminal domain; 1.
DR   InterPro; IPR002087; Anti_prolifrtn.
DR   InterPro; IPR036054; BTG-like_sf.
DR   InterPro; IPR015676; Tob1/2.
DR   PANTHER; PTHR17537:SF6; PROTEIN TOB1; 1.
DR   PANTHER; PTHR17537; TRANSDUCER OF ERBB2 TOB; 1.
DR   Pfam; PF07742; BTG; 1.
DR   PRINTS; PR00310; ANTIPRLFBTG1.
DR   SMART; SM00099; btg1; 1.
DR   SUPFAM; SSF160696; BTG domain-like; 1.
DR   PROSITE; PS00960; BTG_1; 1.
DR   PROSITE; PS01203; BTG_2; 1.
PE   3: Inferred from homology;
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233120}.
FT   DOMAIN          40..60
FT                   /note="Anti-proliferative protein"
FT                   /evidence="ECO:0000259|PROSITE:PS00960"
FT   DOMAIN          86..105
FT                   /note="Anti-proliferative protein"
FT                   /evidence="ECO:0000259|PROSITE:PS01203"
FT   REGION          144..171
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          231..267
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        244..259
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   345 AA;  38155 MW;  3C8AC51B49E1E69F CRC64;
     MQLEIQVALN FIISYLYNKL PRRRVNIFGE ELERLLKKKY EGHWYPEKPY KGSGFRCIHI
     GEKVDPVIEQ ASKESGLDID DVRGNLPQDL SVWIDPFEVS YQIGEKGPVK VLYVDDNNEN
     GCELDKEIKN SFNPEAQVFM PISDPASSVS SSPSPPFGHS AAVSPTFMPR STQPLTFTTA
     TFAATKFGST KMKNSGRSNK VARTSPINLG LNVNDLLKQK AISSSMHSLY GLGLGSQQQP
     QQQQQPAQPP PPPPPPQQQQ QQKTSALSPN AKEFIFPNMQ GQGSSTNGMF PGDSPLNLSP
     LQYSNAFDVF AAYGGLNEKS FVDGLNFSLN NMQYSNQQFQ PVMAN
//
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