ID A0A2K6AXH0_MACNE Unreviewed; 2052 AA.
AC A0A2K6AXH0;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=Citron Rho-interacting kinase {ECO:0000256|PIRNR:PIRNR038145};
DE EC=2.7.11.1 {ECO:0000256|PIRNR:PIRNR038145};
GN Name=CIT {ECO:0000313|Ensembl:ENSMNEP00000003828.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000003828.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000003828.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Plays a role in cytokinesis. Displays serine/threonine
CC protein kinase activity. {ECO:0000256|PIRNR:PIRNR038145}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433,
CC ECO:0000256|PIRNR:PIRNR038145};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775,
CC ECO:0000256|PIRNR:PIRNR038145};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|PIRNR:PIRNR038145}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr
CC protein kinase family. {ECO:0000256|PIRNR:PIRNR038145}.
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DR Ensembl; ENSMNET00000019495.1; ENSMNEP00000003828.1; ENSMNEG00000015804.1.
DR GeneTree; ENSGT01030000234517; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000015804; Expressed in temporal lobe and 7 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0000281; P:mitotic cytokinesis; IEA:UniProtKB-UniRule.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd20814; CRIK; 1.
DR CDD; cd05601; STKc_CRIK; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.340; -; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR000961; AGC-kinase_C.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR017405; Citron_Rho-interacting_kinase.
DR InterPro; IPR001180; CNH_dom.
DR InterPro; IPR037708; CRIK_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR017892; Pkinase_C.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR22988:SF71; CITRON RHO-INTERACTING KINASE; 1.
DR PANTHER; PTHR22988; MYOTONIC DYSTROPHY S/T KINASE-RELATED; 1.
DR Pfam; PF00780; CNH; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF00433; Pkinase_C; 1.
DR PIRSF; PIRSF038145; Citron_Rho-interacting_kinase; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM00036; CNH; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00133; S_TK_X; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51285; AGC_KINASE_CTER; 1.
DR PROSITE; PS50219; CNH; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR038145};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR038145};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|PIRNR:PIRNR038145};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRNR:PIRNR038145};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR038145};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527,
KW ECO:0000256|PIRNR:PIRNR038145};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR038145};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 97..360
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 361..431
FT /note="AGC-kinase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51285"
FT DOMAIN 1373..1422
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 1454..1574
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1617..1907
FT /note="CNH"
FT /evidence="ECO:0000259|PROSITE:PS50219"
FT REGION 1301..1362
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1931..2037
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 458..1223
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1976..2024
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2052 AA; 234897 MW; 068E9AF095F8A914 CRC64;
MLKFKYGTRN PLDAGAAEPI ASRASRLNLF FQGKPPFMTQ QQMSPLSREG ILDALFVLFE
ECSQPALMKI KHVSNFVRKY SDTIAELQEL QPSTKDFEVR SLVGCGHFAE VQVVREKATG
DIHAMKVMKK KALLAQEQVS FFEEERNILS RSTSPWIPQL QYAFQDKNHL YLVMEYQPGG
DLLSLLNRYE DQLDENLIQF YLAELILAVH SVHQMGYVHR DIKPENILID RTGHIKLVDF
GSAAKMNSNK MVNARLPIGT PDYMAPEVLT VMNADGKGTY GLDCDWWSVG VIAYEMIYGR
SPFAEGTSAR TFNNIMNFQR FLKFPDDPKV SSDFLDLIQS LLCGQKERLK FEGLCCHPFF
SKIDWNNIRN SPPPFVPTLK SDDDTSNFDE PEKNSWVSSS PCQLSPSGFL GEELPFVGFS
YSKALGILGR SESVVSGLDS PAKTSSMEKK LLIKSKELQD SQDKCHKMEQ EMTRLHRRVS
EVEAVLSQKE VELKASETQR SLLEQDLATY ITECSSLKRS LEQARMEVSQ EDDKALQLLH
DIREQSRKLQ EIKEQEYQAQ VEEMRLMMNQ LEEDLVSARR RSDLYESELR ESRLAAEEFK
RKATECQHKL LKVINAEQQL KIQELQEKLE KAVKASTEAT ELLQNIRQAK ERAERELEKL
QNREDSSEGI RKKLVEAEER RHSLENKVKR LETMERRENR LKDDIQTKSQ QIQQMADKIL
ELEEKHREAQ VSAQHLEVHL KQKEQHYEEK IKVLDNQIKK DLADKETLEN MMQRHEEEAH
EKGKILSEQK AMINAMDSKI RSLEQRIVEL SEANKLAANS SLFTQRNMKA QEEMISELRQ
QKFYLETQAG KLEAQNRKLE EQLEKISHQD HSDKNRLLEL ETRLREVSLE HEEQKLELKR
QLTELQLSLQ ERESQLTALQ AARAALESQL RQAKTELEET TAEAEEEIQA LTAHRDEIQR
KFDALRNSCT VITDLEEQLN QLTEDNAELN NQNFYLSKQL DEASGANDEI VQLRSEVDHL
RREITEREMQ LTSQKQTMEA LKTTCTMLEE QVMDLEALND ELLEKERQWE AWRSVLGDEK
SQFECRVREL QRMLDTEKQS RARADQRITE SRQVVELAVK EHKAEILALQ QALKEQKLKA
ESLSDKLNDL EKKHAMLEMN ARSLQQKLET ERELKQRLLE EQAKLQQQMD LQKNHIFRLT
QGLQEALDRA DLLKTERSDL EYQLENIQVL YSHEKVKMEG TISQQTKLID FLQAKMDQPA
KKKKVPLQYN ELKLALEKEK ARCAELEEAL QKTRIELRSA REEAAHRKAT DHPHPSTPAT
ARQQIAMSAI VRSPEHQPSA MSLLAPPSSR RKESSTPEEF SRRLKERMHH NIPHRFNVGL
NMRATKCAVC LDTVHFGRQA SKCLECQVMC HPKCSTCLPA TCGLPAEYAT HFTEAFCRDK
MNSPGLQTKE PSSSLHLEGW MKVPRNNKRG QQGWDRKYIV LEGSKVLIYD NEAREAGQRP
VEEFELCLPD GDVSIHGAVG ASELANTAKA DVPYILKMES HPHTTCWPGR TLYLLAPSFP
DKQRWVTALE SVVAGGRVSR EKAEADAARV CVSYELLPAW VQKLLGNSLL KLEGDDRLDM
NCTLPFSDQV VLVGTEEGLY ALNVLKNSLT HVPGIGAVFQ IYIIKDLEKL LMIAGEERAL
CLVDVKKVKQ SLAQSHLPAQ PDISPNIFEA VKGCHLFGAG KIENGLCICA AMPSKVVILR
YNENLSKYCI RKEIETSEPC SCIHFTNYSI LIGTNKFYEI DMKQYTLEEF LDKNDHSLAP
AVFAASSNSF PVSIVQVNSA GQREEYLLCF HEFGVFVDSY GRRSRTDDLK WSRLPLAFAY
REPYLFVTHF NSLEVIEIQA RSSAGTPARA YLDIPNPRYL GPAISSGAIY LASSYQDKLR
VICCKGNLVK ESGTEHHRGP STSRSPNKRG PPTYNEHITK RVASSPAPPE GPSHPREPST
PHRYREGRTE LRRDKSPGRP LEREKSPGRM LSTRRERSPG RLFEDSSRGR LPAGAVRTPL
SQVNKVWDQS SV
//
