ID A0A2K6B061_MACNE Unreviewed; 307 AA.
AC A0A2K6B061;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Sulfotransferase {ECO:0000256|RuleBase:RU361155};
DE EC=2.8.2.- {ECO:0000256|RuleBase:RU361155};
GN Name=HS3ST1 {ECO:0000313|Ensembl:ENSMNEP00000004790.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000004790.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000004790.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the sulfotransferase 1 family.
CC {ECO:0000256|RuleBase:RU361155}.
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DR RefSeq; XP_011749906.1; XM_011751604.1.
DR RefSeq; XP_011749907.1; XM_011751605.1.
DR RefSeq; XP_011749908.1; XM_011751606.1.
DR RefSeq; XP_011749909.1; XM_011751607.1.
DR RefSeq; XP_011749910.1; XM_011751608.1.
DR RefSeq; XP_011749911.1; XM_011751609.1.
DR AlphaFoldDB; A0A2K6B061; -.
DR SMR; A0A2K6B061; -.
DR STRING; 9545.ENSMNEP00000004790; -.
DR Ensembl; ENSMNET00000023919.1; ENSMNEP00000004790.1; ENSMNEG00000021861.1.
DR GeneID; 105487944; -.
DR KEGG; mni:105487944; -.
DR CTD; 9957; -.
DR GeneTree; ENSGT00940000160449; -.
DR OMA; HGRERCL; -.
DR OrthoDB; 10019at2759; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000021861; Expressed in cerebellum and 10 other cell types or tissues.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0008467; F:[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity; IEA:Ensembl.
DR GO; GO:0006024; P:glycosaminoglycan biosynthetic process; IEA:Ensembl.
DR GO; GO:0015012; P:heparan sulfate proteoglycan biosynthetic process; IEA:Ensembl.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR037359; NST/OST.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000863; Sulfotransferase_dom.
DR PANTHER; PTHR10605:SF16; HEPARAN SULFATE GLUCOSAMINE 3-O-SULFOTRANSFERASE 1; 1.
DR PANTHER; PTHR10605; HEPARAN SULFATE SULFOTRANSFERASE; 1.
DR Pfam; PF00685; Sulfotransfer_1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR637359-3};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|RuleBase:RU361155}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..307
FT /note="Sulfotransferase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014457523"
FT DOMAIN 55..294
FT /note="Sulfotransferase"
FT /evidence="ECO:0000259|Pfam:PF00685"
FT ACT_SITE 64
FT /note="For sulfotransferase activity"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-1"
FT BINDING 64..68
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 147
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 155
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 255
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 270..274
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT DISULFID 256..265
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-3"
SQ SEQUENCE 307 AA; 35756 MW; 5E75AACE9B96B073 CRC64;
MAALLLGAVL LVAQPQLVPS RPAELGQQEL LRKAGTLQDD VRYGAAPNGS AQQLPQTIII
GVRKGGTRAL LEMLSLHPDV AAAENEVHFF DWEEHYGHGL GWYLSQMPFS WPHQLTVEKT
PAYFTSPKVP ERVHSMNPSI RLLLILRDPS ERVLSDYTQV FYNHMQKRKP YPSIEEFLVR
DGRLNVDYKA LNRSLYHVHM QNWLRFFPLR HIHIVDGDRL IRDPFPEIQK VERFLKLSPQ
INASNFYFNK TKGFYCLRDS GRDRCLHESK GRAHPQVDPK LLNKLHEYFH EPNKKFFELV
GRTFDWH
//
