ID A0A2K6B0I1_MACNE Unreviewed; 372 AA.
AC A0A2K6B0I1;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=protein-histidine N-methyltransferase {ECO:0000256|ARBA:ARBA00012533};
DE EC=2.1.1.85 {ECO:0000256|ARBA:ARBA00012533};
GN Name=METTL18 {ECO:0000313|Ensembl:ENSMNEP00000004895.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000004895.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000004895.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily. METTL18
CC family. {ECO:0000256|ARBA:ARBA00038126}.
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DR RefSeq; XP_011758780.1; XM_011760478.1.
DR RefSeq; XP_011758781.1; XM_011760479.1.
DR RefSeq; XP_011758782.1; XM_011760480.1.
DR AlphaFoldDB; A0A2K6B0I1; -.
DR STRING; 9545.ENSMNEP00000004895; -.
DR Ensembl; ENSMNET00000024395.1; ENSMNEP00000004895.1; ENSMNEG00000022283.1.
DR GeneID; 105493037; -.
DR KEGG; mni:105493037; -.
DR CTD; 92342; -.
DR GeneTree; ENSGT00390000000464; -.
DR OMA; LCKCRFF; -.
DR OrthoDB; 276605at2759; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000022283; Expressed in thymus and 12 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR GO; GO:0031072; F:heat shock protein binding; IEA:Ensembl.
DR GO; GO:0018064; F:protein-L-histidine N-tele-methyltransferase activity; IEA:Ensembl.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0090069; P:regulation of ribosome biogenesis; IEA:Ensembl.
DR GO; GO:2000232; P:regulation of rRNA processing; IEA:Ensembl.
DR GO; GO:0006448; P:regulation of translational elongation; IEA:Ensembl.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR019410; Methyltransf_16.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR14614; HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN; 1.
DR PANTHER; PTHR14614:SF39; HISTIDINE PROTEIN METHYLTRANSFERASE 1 HOMOLOG; 1.
DR Pfam; PF06325; PrmA; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022603}.
FT REGION 14..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 68..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..51
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 68..92
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 372 AA; 41928 MW; 4EC2218EF15717C0 CRC64;
MTFQFNFTIE DHLENELTPT GDGALTLDSS KELSVSESQK GEDRDRKCSA EQFDLPQGHL
WEHKSMENAA PSQDTDSPLS AANNSSNLEP YGKQPSLRAA KEHAMPKDLK MLENKVIETL
PGFQHVNFSV VKTILLKENF PGENIVSKSF SSHSDLITGV YEGGLKIWEC TFDLLAYFTK
AKVKFAGKKV LDLGCGSGLL GITAFKGGAK EIHFQDYNSM VIDEVTFANV VANSTLEDEE
NDVNKPDLKR CKKPKVTQEL YKCRFFSGEW SEFCKLVLSS EKLFVKYDLI LTSETIYNPD
YYSNLHQTFL RLLSKNGRVL LASKAHYFGV GGGVHLFQKF IEERDVFKTR ILKIIDEGLK
RFIIEITFKS PG
//
