ID A0A2K6B3W8_MACNE Unreviewed; 297 AA.
AC A0A2K6B3W8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Ectodysplasin A2 receptor {ECO:0000313|Ensembl:ENSMNEP00000006102.1};
GN Name=EDA2R {ECO:0000313|Ensembl:ENSMNEP00000006102.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000006102.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000006102.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00206}.
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DR RefSeq; XP_011731148.1; XM_011732846.1.
DR RefSeq; XP_011731149.1; XM_011732847.1.
DR AlphaFoldDB; A0A2K6B3W8; -.
DR Ensembl; ENSMNET00000029589.1; ENSMNEP00000006102.1; ENSMNEG00000026933.1.
DR GeneID; 105476691; -.
DR CTD; 60401; -.
DR GeneTree; ENSGT00940000153259; -.
DR OrthoDB; 5405444at2759; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000026933; Expressed in skeletal muscle tissue and 2 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005031; F:tumor necrosis factor receptor activity; IEA:InterPro.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:InterPro.
DR GO; GO:0046330; P:positive regulation of JNK cascade; IEA:InterPro.
DR CDD; cd15838; TNFRSF27; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 1.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR InterPro; IPR022319; TNFR_27.
DR InterPro; IPR034060; TNFRSF27_N.
DR InterPro; IPR047526; TNR19/27/EDAR.
DR PANTHER; PTHR12120; TNFR-CYS DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR12120:SF8; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 27; 1.
DR Pfam; PF00020; TNFR_c6; 2.
DR PRINTS; PR01973; TNFACTORR27.
DR SMART; SM00208; TNFR; 2.
DR SUPFAM; SSF57586; TNF receptor-like; 1.
DR PROSITE; PS00652; TNFR_NGFR_1; 2.
DR PROSITE; PS50050; TNFR_NGFR_2; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00206}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 137..162
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 2..41
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 2..41
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 43..83
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 43..83
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT REGION 269..297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 269..286
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 18..31
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
SQ SEQUENCE 297 AA; 32792 MW; BF5F2CD65B7E1E07 CRC64;
MDCQENEYWD QWGRCVTCQR CGPGQELSKD CGYGEGGDAY CTACPPRRYK SSWGHHRCQS
CITCAVINRV QKVNCTATSN AVCGDCLPRF YRKTRIGGLQ EQECIPCTKQ TPTSEVQCAF
QLSLVEADAP TVPPQEAALV ALVSSLLVVF TLAFLGLFFL YCKQFFNRHC QRGGSLKFQA
DKTAEEESLF PMAPSKETSP EPQMSESIFQ TQPLNPILED DCSSTSGFPT QDSFTTASCA
SESHSHWVHN PIECTELDLQ KFSSSASYTG AETLRGNTTE STGDRLELNV TFEVPSP
//