ID A0A2K6B5N2_MACNE Unreviewed; 5162 AA.
AC A0A2K6B5N2;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=SCO-spondin {ECO:0000256|ARBA:ARBA00020523};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000006690.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000006690.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space
CC {ECO:0000256|ARBA:ARBA00004239}.
CC -!- SIMILARITY: Belongs to the thrombospondin family.
CC {ECO:0000256|ARBA:ARBA00009456}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00039}.
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DR STRING; 9545.ENSMNEP00000006690; -.
DR Ensembl; ENSMNET00000030758.1; ENSMNEP00000006690.1; ENSMNEG00000027715.1.
DR GeneTree; ENSGT00940000155829; -.
DR OMA; QTKNELC; -.
DR Proteomes; UP000233120; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0098797; C:plasma membrane protein complex; IEA:UniProt.
DR GO; GO:0030414; F:peptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd00057; FA58C; 1.
DR CDD; cd00112; LDLa; 8.
DR CDD; cd19941; TIL; 15.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 15.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 8.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 25.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR008037; Pacifastin_dom.
DR InterPro; IPR036201; Pacifastin_dom_sf.
DR InterPro; IPR036084; Ser_inhib-like_sf.
DR InterPro; IPR002919; TIL_dom.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR014853; VWF/SSPO/ZAN-like_Cys-rich_dom.
DR InterPro; IPR001007; VWF_dom.
DR InterPro; IPR001846; VWF_type-D.
DR PANTHER; PTHR11339; EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED; 1.
DR PANTHER; PTHR11339:SF396; SCO-SPONDIN; 1.
DR Pfam; PF08742; C8; 3.
DR Pfam; PF00754; F5_F8_type_C; 1.
DR Pfam; PF00057; Ldl_recept_a; 6.
DR Pfam; PF05375; Pacifastin_I; 1.
DR Pfam; PF01826; TIL; 12.
DR Pfam; PF00090; TSP_1; 22.
DR Pfam; PF00094; VWD; 3.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00832; C8; 3.
DR SMART; SM00231; FA58C; 1.
DR SMART; SM00192; LDLa; 9.
DR SMART; SM00209; TSP1; 25.
DR SMART; SM00214; VWC; 6.
DR SMART; SM00215; VWC_out; 10.
DR SMART; SM00216; VWD; 3.
DR SUPFAM; SSF57603; FnI-like domain; 3.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 9.
DR SUPFAM; SSF57283; PMP inhibitors; 1.
DR SUPFAM; SSF57567; Serine protease inhibitors; 14.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 24.
DR PROSITE; PS01225; CTCK_2; 1.
DR PROSITE; PS01286; FA58C_2; 1.
DR PROSITE; PS50022; FA58C_3; 1.
DR PROSITE; PS01209; LDLRA_1; 3.
DR PROSITE; PS50068; LDLRA_2; 9.
DR PROSITE; PS50092; TSP1; 26.
DR PROSITE; PS01208; VWFC_1; 1.
DR PROSITE; PS50184; VWFC_2; 2.
DR PROSITE; PS51233; VWFD; 3.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..5162
FT /note="SCO-spondin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014356310"
FT DOMAIN 195..364
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 565..738
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 1016..1186
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 1963..2023
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 2063..2222
FT /note="F5/8 type C"
FT /evidence="ECO:0000259|PROSITE:PS50022"
FT DOMAIN 5001..5057
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 5056..5155
FT /note="CTCK"
FT /evidence="ECO:0000259|PROSITE:PS01225"
FT REGION 1518..1550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1624..1643
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2300..2336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3502..3529
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1519..1533
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2309..2323
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 1420..1432
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1427..1445
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1482..1494
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1489..1507
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1555..1567
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1562..1580
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1574..1589
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1659..1677
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2232..2244
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2239..2257
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2251..2266
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2389..2401
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2396..2414
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2408..2423
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2456..2468
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2463..2481
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2475..2490
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 5162 AA; 549102 MW; F5D824591CB15052 CRC64;
MLLPALLFGM VWALADGRWC EWTETIRVEE EVVPRQEDLV PCASLDHYSR LGWRLDLPWS
VRAGLTRSPV PGLCPIYKPP ETRPAKRNRT VRACCPGWGG AHCHLSAFGE VVPSGSHCFA
MWQCQLQAGS ANASAGSLEE CCAWPWGRSW RDGSSQACLS CSSRHLPGGA SSPALLQPLA
GAVGQLWSQH QRPSATCASW SGFHYRTFDG RHYHFLGRCT YLLAGAADST WAVHLTPGDH
CPQPGHCQLV TMGPEEVLIQ AGNVSVKGQL VPEGQSWLLH GLSLQWLGDW LVLSGGLGVV
VRLDRAGSIS ISVDHELWGQ TQGLCGLYNG QPEDDFMEPG GGLAMLAATF GNSWKLPDSE
PGCLDAVEVA QGCDGPLGLT QADVEPGHLR AEAQDVCHQL LEGPFGQCHA QVSPAEYHEA
CLFAYCAAAM AGSRQEGQRQ AVCATFASYA QACARRHIHI RWRKPGFCER LCPGGQLYSD
CTSLCPPSCE AVGQGEEESC REECVSGCEC PRGLFWNGTL CVPAAHCPCY YRRQRYAPRD
TVRQLCNPCV CRDGRWHCAQ ALCPAECAVG GDGHYLTFDG RSYSFRGGQG CRYSLVQDYV
KGQLLILLEH GACDSGSCLH AISVSLEDTH IQLRDSGAVL VNGQDVGLPW IGADGLSVRR
TSSAFLLLRW PGAQVLWGLS DPAAYITLDP RHAHQVQGLC GTFTQNQQDD FLTPAGDVET
SIAAFASKFQ VAGKGRCPSG DSAPLSPCTT HSQRHTFAET ACAILHSSVF QECHRLVDRE
PFYLRCLAAV CGCDPGRDCL CPVLSAYARR CAQEGASPPW RNQTLCPVLC PGGQEYRECA
PACGQHCGEP EDCGELGSCV ASCNCPLGLL WDPEGQCVPP SSCPCQLGAR RYAPGSATMK
ECNRCVCQER GLWNCTAHRC PPQQAFCPRE LVYAPGACLL TCDSPTANHS CPAGSADGCV
CPPGMVLLDE HCVPPDLCPC RHSGQWYPPN ATIQEDCNVC VCRGRQWHCT GQRCSGRCQA
SGAPHYMTFD GLAFTFPGAC EYLLVREASG LFTVSAQNLP CGASGLTCTK ALAVRLEGIV
VHMLRGRAVT VNGLSVTPPK VYTGPGLSLR RAGLFLLLST RLGLTLLWDG GTRVLVQLSP
QFRGRVAGLC GDFDGDASND LRSRQGVLEP TAELAAHSWR LSTLCPEPGD LPHPCVVNTH
RAGWARARCG VLLQPLFASC HAEVPPQQHY EWCLHDACGC DSGGDCECLC SAIATYADEC
ARHGYHVRWR SQELCPLQCE GGQVYEACGP TCPPTCHEQH PEPGWHCQVV ACVEGCFCPE
GTLLHGGACL EPASCPCEWG SNSFPPGSVL QKDCGNCTCQ EGQWRCGGDG GRCEEPAPGC
AEGEVLCQEN GHCVPHGWLC DNQDDCGDGS DEEGECLCSC VEGLLACADG RCLPPALLCD
GHPDCPDLAP TSPPPSFARF LWGTPNSTGA SSSFLAAGQV TCVPGEVSCV DGTCLGAIQL
CDGVWDCPDG ADEGPGHCPL PSLPTPPAGT LPGPSPGSLD TAPSSLASAS PAPPCGPFEF
RCGSGECIPR GWRCDQEEDC PDGSDERGCE EPCAPHDAPC ARGPHCVSPE QLCDGVRQCP
DGSDEGPDAC GEAPAPPGPA GWARDAAHTP WLPCPEYTCP NGTCIGFQLV CDGQPDCGGS
GQAGPSPEEQ GCGAWGPWSP WGPCSRTCGP GGQGRSRRCS PLGLLVLQHC PGPEHQSQTC
FTAACPVDGE WSAWSPWSVC SEPCRGTMTR QRQCHPPQNG GRTCAALPGG PHSTRQTKPC
PQDSCPNATC SGELMFQPCA PCPLTCDDIS GQVMCPPDWP CGSPGCWCPE GQVLGSEGWC
VWPRQCPCLV DGARYWPGQR IKADCRLCIC QDGRPRRCRL NPDCAVDCGW SSWSPWAECL
GPCGSQSIQW SFRSPNNPRP SGRGRQCRGI HRKARRCQTE PCEGCEHQGQ VHRVGERWRG
GPCSVCQCLH NLTAQCSPYC PLGSCPQGWV LVEGTGESCC HCALPGENQT VQPMATPAAA
PAPSPQIGFP LATYILPPPG DPCYSPLGLA GLAKGSLHAS SQQLEHPTQA ALMGAPTQEP
RPHGWRAGGH AYAKWHTRPH YLQLDLLQPR NLTGIIVPET GSSNASATSF SLQFSSNGLR
WHDYHDILPG ILPLPKLFPR HWDDLDPAVW TFGQMVQARF VRVWPRDAHH SDVPLRVELL
GCEPGSPLAP LCPGVGLRCA SGECALRGRL CDGVLDCKDG SDEEGCVLLP EGTGRFHSTA
KTLALSSAQP GQLLHWPGEG LAETEHWPPG QESPTSPTET RPVSPGPASG VPHHGESMQM
VTTTPISQME ARTLPPGMAA VTVLPPRPVT PATPAGQSVA PGPFPPVRCG PGQMPCEVLG
CVEQAQVCDG REDCLDGSDE RHCGELLEGL PSSASTVPFT VPTMALPGLP ASRALCSPSQ
LSCGSGECLS AERRCDLRPD CQDGSDEDGC VDCVLAPWSV WSSCSRSCGL GLTFQRQELL
QPPLPGGSCP PDRFRSQSCF VQACPVAGAW AMWEAWGPCS VSCGGGHQSR RRSCMDPPPK
NNGAPCPGPS HERVPCGLQP CSGGTDCELG RVYVSADLCQ KGLVPPCPPS CLDPKANRSC
SGHCMEGCRC PPGLLLHDTR CLPLSECPCL VGEELKWPGV SFVLANCSQC VCEKGELLCQ
PGGCPLPCGW SAWSSWAPCD RSCGSGVRAR FRSPSNPPAA WGGAPCEGDR QELQGCHTEC
GTEVLGWTPW TSWSSCSQSC LVPGGGPGWR SRSRLCPSPG DSSCPGEATQ EEPCSPPVCP
VPSIWGLWAP WSTCSAPCDG GIQTRGRSCS SLAPGDSSCP GPHSQTRDCN TQPCTAQCPE
NMVFRSAEQC RQEGGPCPRL CLTHGPGIEC SGFCAPGCTC PPGLFLHNAS CLPRSQCPCQ
LHGQLYAPGA MARLDSCNNC TCVSGEMACT SEHCPVACGW SPWTPWSLCS RSCNVGIRRR
FRAGTAPPAA FGGAECQGPT MEAEFCSLRP CRGESPETSL KNLPERSPGG EWGPWSPCSV
PCGGGYRNRT RGSGLHSPME FSTCGLQPCT GPVPGVCPRD KQWLDCAQGP ASCAELSTSR
GTNKTCHPGC HCPSGMLLLN NVCVPTQDCP CAHEGHLYPP GSTVVRPCEN CSCVSGLIAN
CSSWPCVEGE PTWSPWTPWS QCSASCGPAR RHRHRFCARS PSAAPSTVAP LSLPATHTPL
CPGPEAEEEP CLLPGCDRAG GWGPWGTWSH CSRSCGGGLR SRTRACDQPP PQGLGDYCEG
PRAQGEACQA LPCPVTNCTA IEGAEYSPCG PPCPRSCDDL VHCVWHCQPG CYCPPGQVLS
SNGAICVQPG HCDCLDLLTG QRHHPGAQLA RPDGCNHCTC LEGRLNCTDL PCPVPGGWCP
WSEWTLCSQP CRGQTRSRSR ACTCPTPQHG GAPCTGETGE AGAQHQREAC PSSAMCPVDG
AWGPWGPWSS CDTCLGQSHR SRACSQPPTP EGGRPCPGSH TQSRPCQDNS TRCTDCGGGQ
SLHPCGQPCP RSCQDLSPGS VCQPGSAGCQ PSCGCPLGQL SQDGLCVPLA RCRCQYQPGA
MGIPENQSRS AGSRFSSWES LEPGEVITGP CDNCTCVAGI LQCQEVPGCP DPGEWTSWGP
WEDCSVSCGG GEQLRSRRCA RPPCPGPARQ SRTCSTQVCR EAGCPAGRLY RECQPSEGCP
FSCTHITQQV GCFSEGCEEG CHCPEGTFQH RLACVQECPC VLTVWLLQEL GAARADPGQS
LGPGDELGSG QTLHTSCGNC SCAHGTLSCS LEDCFEAGGG FGPWSPWGPC SRSCGGLGTR
TRSRQCVLPM PVPSGQGCRG PRQGLEYCPS PDCPGAEGST VEPVTGLPGG WGPWSSWSPC
SGSCTDPARP AWRSRTRLCL ANCTMGDPLQ ERPCNLPSCT ELPLCPGPGC GAGNCSWTSW
APWEPCSRSC GVGQQRRLRA YRPPGPSGHW CPDILTAYQE RRFCNLRACP VPGGWSRWSP
WSWCDRSCGG GQSLRSRSCS SPPPKNGGAP CAGEWHQARL CNPTPCEAGC PAGMEVVTCA
NRCPRRCSDL QEGIVCQDDQ VCQKGCRCPK GSLEQDGGCV PIGHCDCTDA QGHIWAPGSQ
HQDACNNCSC QAGRLFCTAQ PCPPPTHCAW SRWSAWSPCS HSCGPGGQQS RFRSSTSGSW
APECREEQSQ SQRCPQPSCP PLCLQGTHPR TLGDSWLHGE CQQCSCTPEG VICEDTECAV
PEAWTLWSSW SDCPVSCGGG NQIRTRACRA AAPHHGSPPC LGPDTQTQPC GQQPCPGLLE
ACSWGPWGPC SRSCGLGLAS RSGSCPCLIA KADPTCNGTF LHLDTQGCYP GPCPEECVWS
SWSSWTRCSC QVLVQQRYRH QGPASQGARA GAPCTRLDGH FRPCLIGNCS EDSCTPPFEF
HACGSPCAGL CATHLSHQLC QDLPPCQPGC YCPKGLLEQA GGCIPLEQCN CWHTSAAGAR
ITLAPGDRLQ LGCKECECRR GELHCTSQGC QGLLPLSEWS EWSPCGPCLP PSALASASRT
ALEERWLQDP TSLSPTSAPL LASEQHRHRL CLDPVTGRPW TGAPHLCTAP LRQQRLCPDP
GACPDSCQWS LWGPWSPCQV PCSGGFRLRW RGTEAPTGGG CQGPWAQTES CNRGPCPGES
CEARNTVFTL DCASQCPRSC ADLWDRVQCL QGPCRPGCRC PPGQLVQDGH CVPISSCRCG
LPSANASWEL APAQVVQLDC QNCTCVNGSL VCPHQGCPVL GPWSAWSSCS APCGGGTMER
HRSCEGGPGM APCQAQDTEQ RQECNLQPCP ECPPGQVLSA CATSCPRLCW HLQPGAICVQ
EPCQPGCGCP GGQLLHNGTC MPPTACPCTQ HSLPWGLTLT LEEQAQELPP GTVLTRNCTR
CVCHGGAFSC SLIDCQECPP GEMWQQVAPG ELGLCEQTCQ DMNATETRSN CSSARTSGCV
CQPGHFRSQA GPCVPEDLCE CWHLGHPHLP GSEWQEACES CLCLSGRPVC TQRCSPLTCA
QGEEMVLEPG SCCPSCRREA LEEQLPSCQL LTELRNFTKG TCYLDKVEVS YCSGYCPSST
HVMPEEPYLQ SQCDCCSYRL DPESPVRILN LRCLGGHTEP VVLPVIHSCQ CSSCQGGDFS
KH
//
