ID   A0A2K6B759_MACNE        Unreviewed;       171 AA.
AC   A0A2K6B759;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=Granulocyte colony-stimulating factor {ECO:0000256|ARBA:ARBA00019452};
GN   Name=CSF3 {ECO:0000313|Ensembl:ENSMNEP00000007251.1};
OS   Macaca nemestrina (Pig-tailed macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000007251.1, ECO:0000313|Proteomes:UP000233120};
RN   [1] {ECO:0000313|Ensembl:ENSMNEP00000007251.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Granulocyte/macrophage colony-stimulating factors are
CC       cytokines that act in hematopoiesis by controlling the production,
CC       differentiation, and function of 2 related white cell populations of
CC       the blood, the granulocytes and the monocytes-macrophages. This CSF
CC       induces granulocytes. {ECO:0000256|ARBA:ARBA00024794}.
CC   -!- SIMILARITY: Belongs to the IL-6 superfamily.
CC       {ECO:0000256|ARBA:ARBA00007432}.
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DR   AlphaFoldDB; A0A2K6B759; -.
DR   Ensembl; ENSMNET00000031401.1; ENSMNEP00000007251.1; ENSMNEG00000028190.1.
DR   GeneTree; ENSGT00390000017328; -.
DR   Proteomes; UP000233120; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0005125; F:cytokine activity; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0045639; P:positive regulation of myeloid cell differentiation; IEA:InterPro.
DR   Gene3D; 1.20.1250.10; -; 2.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR040117; GCSF/MGF.
DR   InterPro; IPR030474; IL-6/GCSF/MGF.
DR   PANTHER; PTHR10511; GRANULOCYTE COLONY-STIMULATING FACTOR; 1.
DR   PANTHER; PTHR10511:SF2; GRANULOCYTE COLONY-STIMULATING FACTOR; 1.
DR   Pfam; PF16647; GCSF; 1.
DR   PRINTS; PR00433; IL6GCSFMGF.
DR   SMART; SM00126; IL6; 1.
DR   SUPFAM; SSF47266; 4-helical cytokines; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           31..171
FT                   /note="Granulocyte colony-stimulating factor"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5014394199"
SQ   SEQUENCE   171 AA;  18608 MW;  DCA2D0C83338F900 CRC64;
     MAIPAAQSPM KLMALQLLLW HSALWTVQEA TPLGPASSLP QSFLLKCLEQ VRKIQGDGAA
     LQEKLVSETG CLSQLHSSLF LYQGLLQALE GISPELGPTL DTLQLDIADF ATTIWQQMED
     LGMAPALQPT QGAMPAFTSA FQRRAGGVLV ASHLQRFLEL AYRVLRHLAQ S
//