ID A0A2K6B9F2_MACNE Unreviewed; 905 AA.
AC A0A2K6B9F2;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Endoplasmic reticulum metallopeptidase 1 {ECO:0000313|Ensembl:ENSMNEP00000008048.1};
GN Name=ERMP1 {ECO:0000313|Ensembl:ENSMNEP00000008048.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000008048.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000008048.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the peptidase M28 family.
CC {ECO:0000256|ARBA:ARBA00010918}.
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DR RefSeq; XP_011752155.1; XM_011753853.1.
DR AlphaFoldDB; A0A2K6B9F2; -.
DR Ensembl; ENSMNET00000032212.1; ENSMNEP00000008048.1; ENSMNEG00000028561.1.
DR GeneTree; ENSGT00530000063839; -.
DR OMA; HFWIEAE; -.
DR OrthoDB; 277019at2759; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000028561; Expressed in adult mammalian kidney and 12 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008235; F:metalloexopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd03875; M28_Fxna_like; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR048024; Fxna-like_M28_dom.
DR InterPro; IPR045175; M28_fam.
DR InterPro; IPR007484; Peptidase_M28.
DR PANTHER; PTHR12147:SF26; ENDOPLASMIC RETICULUM METALLOPEPTIDASE 1; 1.
DR PANTHER; PTHR12147; METALLOPEPTIDASE M28 FAMILY MEMBER; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00023049};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 420..438
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 450..476
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 488..511
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 523..545
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 551..569
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 581..604
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 624..646
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 653..675
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 186..379
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
FT REGION 1..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..27
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 905 AA; 100266 MW; 9D8BEB7EF136E93F CRC64;
MEWGSESAAV RRHRVGGERR DGPAAAPPPE REARAQEPLV DGCGGGGGRT RKRSLGGSGG
ASRGAGTGLS EARAALGLAL YLLALRTLVQ LSLQQLVLRG TAGHHGEFDA LQARDYLEHI
TSIGPRTTGS PENEILTVHY LLEQIKLIEV QSNRLHKISV DVQRPTGSFS IDFLGGFTSY
YDNITNVVVK LEPRDGAQHA VLANCHFDSV ANSPGASDDA VSCSVMLEVL RVLSTSSEAL
HHAVIFLFNG AEENVLQASH GFITQHPWAS LIRAFINLEA AGVGGKELVF QTGPENPWLV
QAYVSAAKHP FASVVAQEVF QSGIIPSDTD FRIYRDFGNI PGIDLAFIEN GYIYHTKYDT
ADRILTDSIQ RAGDNILAVL KHLATSDMLA AASKYRHGNM VFFDVLGLFV IAYPSRIGSI
INYMVVMGVI LYLGKKLLQP KHKTGNYKKD FLCGLGITLI SWFTSLVTVL IIAVFISLIG
QSLSWYNHFY VSVCLYGTAT VAKIIFIHTL AKRFYYMNVS DQYLGEVFFD IALFVHCCSL
VTLTYQGLCS AFISAVWVAF PLLTKLCVHK DFKQHGAQGK FIAFYLLGMF IPYLYALYLI
WAVFEMFTPI LGRSGSEIPP DVVLASILAG CTMILSSYFI NFIYLAKSTK KTMLTLTLVC
AITFLLVCSG TFFPYSSNPA NPKPKRVFLQ HVTRTFHDLE GNAVKRDSGI WINGFDYTGM
SHITPHIPEI NDSIRAHCEE NAPLCGFPWY LPVHFLIRKN WYLPAPEVSP RNPAHFQLIS
KEQTPWDSIK LTFEATGPSH MSFYVRAHKG STLSQWSLGN GTPVTSKGGD YFVFYSHGLQ
ASAWQFWIEV QVSEEHPEGM VTVAIAAHYL SGEDKRSPQL DALKERFPDW TFPSAWVCTY
DLFVF
//
