ID   A0A2K6B9H6_MACNE        Unreviewed;       235 AA.
AC   A0A2K6B9H6;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=T-cell surface glycoprotein CD8 alpha chain {ECO:0000256|ARBA:ARBA00021525};
GN   Name=CD8A {ECO:0000313|Ensembl:ENSMNEP00000008067.1};
OS   Macaca nemestrina (Pig-tailed macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000008067.1, ECO:0000313|Proteomes:UP000233120};
RN   [1] {ECO:0000313|Ensembl:ENSMNEP00000008067.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A2K6B9H6; -.
DR   Ensembl; ENSMNET00000032231.1; ENSMNEP00000008067.1; ENSMNEG00000028566.1.
DR   GeneTree; ENSGT00940000156588; -.
DR   OMA; FRMSPTQ; -.
DR   Proteomes; UP000233120; Unplaced.
DR   Bgee; ENSMNEG00000028566; Expressed in thymus and 7 other cell types or tissues.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR   CDD; cd05720; IgV_CD8_alpha; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR015468; CD8_asu.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   PANTHER; PTHR10441; CD8 ALPHA CHAIN; 1.
DR   PANTHER; PTHR10441:SF2; T-CELL SURFACE GLYCOPROTEIN CD8 ALPHA CHAIN; 1.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00406; IGv; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..235
FT                   /note="T-cell surface glycoprotein CD8 alpha chain"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5014391772"
FT   TRANSMEM        183..206
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          21..117
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
SQ   SEQUENCE   235 AA;  25763 MW;  8FF76B7144C00BCA CRC64;
     MAPPVTALLL PLVLLLHAAR PNQFRVSPLG RTWNLGETVE LKCQVLLSNP TSGCSWLFQP
     RGTAARPTFL LYLSQNKPKA AEGLDTQRFS GKRLGDTFVL TLRDFRQENE GYYFCSALSN
     SIMYFSLFVP VFLPAKPTTT PAPRPPTPAP TTASQPLSLR PEACRPAAGG SVNTRGLDFA
     CDIYIWAPLA GACGVLLLSL VITLYCNHRN RRRVCKCPRP VVKSGGKPSL SDRYV
//