ID A0A2K6BAC9_MACNE Unreviewed; 862 AA.
AC A0A2K6BAC9;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Notch receptor 2 {ECO:0000313|Ensembl:ENSMNEP00000008382.1};
GN Name=NOTCH2 {ECO:0000313|Ensembl:ENSMNEP00000008382.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000008382.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000008382.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A2K6BAC9; -.
DR Ensembl; ENSMNET00000032549.1; ENSMNEP00000008382.1; ENSMNEG00000028518.1.
DR GeneTree; ENSGT00940000155030; -.
DR OMA; FTGQTCG; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000028518; Expressed in lung and 12 other cell types or tissues.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 13.
DR Gene3D; 2.10.25.10; Laminin; 20.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR PANTHER; PTHR24033; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24033:SF151; PROTEIN EYES SHUT; 1.
DR Pfam; PF00008; EGF; 12.
DR Pfam; PF07645; EGF_CA; 3.
DR Pfam; PF12661; hEGF; 5.
DR PRINTS; PR00010; EGFBLOOD.
DR PRINTS; PR01983; NOTCH.
DR SMART; SM00181; EGF; 20.
DR SMART; SM00179; EGF_CA; 20.
DR SUPFAM; SSF57196; EGF/Laminin; 11.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR PROSITE; PS00010; ASX_HYDROXYL; 14.
DR PROSITE; PS00022; EGF_1; 19.
DR PROSITE; PS01186; EGF_2; 16.
DR PROSITE; PS50026; EGF_3; 21.
DR PROSITE; PS01187; EGF_CA; 7.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..24
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 25..63
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 66..104
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 105..141
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 143..180
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 182..219
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 221..257
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 259..297
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 299..335
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 336..374
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 376..415
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 417..453
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 455..491
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 493..529
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 531..566
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 568..604
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 606..641
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 643..679
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 681..716
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 718..754
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 756..789
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 14..23
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 34..51
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 53..62
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 94..103
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 131..140
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 170..179
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 209..218
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 247..256
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 287..296
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 325..334
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 345..362
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 364..373
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 405..414
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 443..452
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 481..490
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 519..528
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 535..545
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 556..565
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 594..603
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 610..620
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 631..640
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 669..678
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 685..695
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 706..715
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 744..753
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 862 AA; 92214 MW; C8E9C9E81BD5432B CRC64;
MCVTYHNGTG YCKCPEGFLG EYCQHRDPCE KNRCQNGGTC VAQAMLGKAT CRCASGFTGE
DCQYSTSHPC FVSRPCLNGG TCHMLSRDTY ECTCQVGFTG KECQWTDACL SHPCANGSTC
TTVANQFSCK CLTGFTGQKC ETDVNECDIP GHCQHGGTCL NLPGSYQCQC PQGFTGQHCD
SLYVPCAPSP CVNGGTCRQT GDFTFECNCL PGFEGSTCER NIDDCPNHRC QNGGVCVDGV
NTYNCRCPPQ WTGQFCTEDV DECLLQPNAC QNGGTCANRN GGYGCVCVNG WSGDDCSENI
DDCAFASCTP GSTCIDRVAS FSCMCPEGKA GLLCHLDDAC ISNPCHKGAL CDTNPLNGQY
ICTCPQGYKG ADCTEDVDEC AMANSNPCEH AGKCVNTDGA FHCECLKGYA GPRCEMDINE
CHSDPCQNDA TCLDKIGGFT CLCMPGFKGV HCELEINECQ SNPCVNNGQC VDKVNRFQCL
CPPGFTGPVC QIDIDDCSST PCLNGAKCID HPNGYECQCA TGFTGVLCEE NIDNCDPDPC
HHGQCQDGID SYTCICNPGY MGAICSDQID ECYSSPCLND GRCIDLVNGY QCNCQPGTSG
VNCEINFDDC ASNPCIHGIC MDGINRYSCV CSPGFTGQRC NIDIDECASN PCRKGATCIN
GVNGFRCICP EGPHHPSCYS QVNECLSNPC IHGNCTGGLS GYKCLCDAGW VGINCEVDKN
ECLSNPCQNG GTCDNLVNGY RCTCKKGFKG YNCQVNIDEC ASNPCLNQGT CFDDISGYTC
HCVLPYTGGS WKYQGPEGIL GLALSVPESE CPGLWGCSAA PRAHSSVVLP ALTDWILSFE
ETLWPPKMQV VDSHLPTLYL SI
//
