ID   A0A2K6BB05_MACNE        Unreviewed;       436 AA.
AC   A0A2K6BB05;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   RecName: Full=Mitochondrial import inner membrane translocase subunit TIM50 {ECO:0000256|RuleBase:RU365079};
OS   Macaca nemestrina (Pig-tailed macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000008588.1, ECO:0000313|Proteomes:UP000233120};
RN   [1] {ECO:0000313|Ensembl:ENSMNEP00000008588.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Essential component of the TIM23 complex, a complex that
CC       mediates the translocation of transit peptide-containing proteins
CC       across the mitochondrial inner membrane.
CC       {ECO:0000256|RuleBase:RU365079}.
CC   -!- SUBUNIT: Component of the TIM23 complex.
CC       {ECO:0000256|RuleBase:RU365079}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004167}. Mitochondrion
CC       inner membrane {ECO:0000256|ARBA:ARBA00004434,
CC       ECO:0000256|RuleBase:RU365079}; Single-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004434, ECO:0000256|RuleBase:RU365079}.
CC   -!- SIMILARITY: Belongs to the TIM50 family.
CC       {ECO:0000256|ARBA:ARBA00006344, ECO:0000256|RuleBase:RU365079}.
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DR   AlphaFoldDB; A0A2K6BB05; -.
DR   STRING; 9545.ENSMNEP00000008588; -.
DR   Ensembl; ENSMNET00000032756.1; ENSMNEP00000008588.1; ENSMNEG00000028763.1.
DR   GeneTree; ENSGT01040000240503; -.
DR   Proteomes; UP000233120; Unplaced.
DR   Bgee; ENSMNEG00000028763; Expressed in skeletal muscle tissue and 12 other cell types or tissues.
DR   GO; GO:0005744; C:TIM23 mitochondrial import inner membrane translocase complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0004722; F:protein serine/threonine phosphatase activity; IEA:UniProt.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   CDD; cd07521; HAD_FCP1-like; 1.
DR   Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR   InterPro; IPR004274; FCP1_dom.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR023214; HAD_sf.
DR   PANTHER; PTHR12210; DULLARD PROTEIN PHOSPHATASE; 1.
DR   PANTHER; PTHR12210:SF3; MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM50; 1.
DR   Pfam; PF03031; NIF; 1.
DR   SMART; SM00577; CPDc; 1.
DR   SUPFAM; SSF56784; HAD-like; 1.
DR   PROSITE; PS50969; FCP1; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00022792};
KW   Mitochondrion {ECO:0000256|ARBA:ARBA00023128,
KW   ECO:0000256|RuleBase:RU365079};
KW   Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792};
KW   Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW   ECO:0000256|RuleBase:RU365079};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW   Transit peptide {ECO:0000256|ARBA:ARBA00022946,
KW   ECO:0000256|RuleBase:RU365079};
KW   Translocation {ECO:0000256|ARBA:ARBA00023010,
KW   ECO:0000256|RuleBase:RU365079}; Transport {ECO:0000256|RuleBase:RU365079}.
FT   DOMAIN          226..369
FT                   /note="FCP1 homology"
FT                   /evidence="ECO:0000259|PROSITE:PS50969"
FT   REGION          115..153
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   436 AA;  48258 MW;  FC7AD0D3AE245D6E CRC64;
     MASALPLGNE CDPFPRCVLC RGGGALQGPI GAPPEAARRM VRGKRACSNP PDDFGLSRAS
     VHPPRLRASI GCSSGPGRVK RERVGGAAWR QRKMAASAAL CSRLRSGLRL GSRGLCTRLA
     TPPPRAPDQA AEIGSRGGTK AQGPQQQPGS EGPSYAKKVA LWLAGLLGAG GTVSVVYIFG
     NNTVDENDPI LVQQLRRTYK YFKDYRQMII EPTSPCLLPD PLQEPYYQPP YTLVLELTGV
     LLHPEWSLAT GWRFKKRPGI ETLFQQLAPL YEIVIFTSET GMTAFPLIDS VDPHGFISYR
     LFRDATRYMD GHHVKDISCL NRDPARVVVV DCKKEAFRLQ PYNGVALRPW DGNSDDRVLL
     DLSAFLKTIA LNGVEDVRTV LEHYALEDDP LAAFKQRQSR LEQEEQQRLA ELSKSNKQNL
     FLGSLTSRLW PRSRQP
//