ID A0A2K6BCX6_MACNE Unreviewed; 830 AA.
AC A0A2K6BCX6;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=Tight junction protein 3 {ECO:0000313|Ensembl:ENSMNEP00000009255.1};
GN Name=TJP3 {ECO:0000313|Ensembl:ENSMNEP00000009255.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000009255.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000009255.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC {ECO:0000256|ARBA:ARBA00004435}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004413}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
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DR AlphaFoldDB; A0A2K6BCX6; -.
DR STRING; 9545.ENSMNEP00000009255; -.
DR Ensembl; ENSMNET00000033426.1; ENSMNEP00000009255.1; ENSMNEG00000029063.1.
DR GeneTree; ENSGT00940000160036; -.
DR OMA; MEEVTIW; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000029063; Expressed in colon and 2 other cell types or tissues.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR CDD; cd00992; PDZ_signaling; 2.
DR Gene3D; 2.30.42.10; -; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR005417; ZO.
DR InterPro; IPR005420; ZO-3.
DR PANTHER; PTHR13865; TIGHT JUNCTION PROTEIN; 1.
DR PANTHER; PTHR13865:SF11; TIGHT JUNCTION PROTEIN ZO-3; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR01597; ZONOCCLUDNS.
DR PRINTS; PR01600; ZONOCCLUDNS3.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00228; PDZ; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50106; PDZ; 2.
PE 4: Predicted;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00022475};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443};
KW Tight junction {ECO:0000256|ARBA:ARBA00022427}.
FT DOMAIN 1..65
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 305..371
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 582..672
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT REGION 64..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 238..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 703..830
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 65..79
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..100
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 795..819
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 830 AA; 91016 MW; 675F1885616CCE44 CRC64;
PVAGGVVVAE IVPLTPAEGD RAMTLTGDHI AMVNGVSMEN ATSTFVIQTL KTCAKMANIT
VKRPRRIQLP TTTKASPSGP GHRDSDEDDG PHRVEEVDQG QGYDGDSSSG SGRSWDERSR
RQRPGRRGRA SSHGRRSPGG DSEANGLALV SGFKRLPRQD VQMKPVKSVL VKRRDSEGEA
GGQVRSDLDH RAPWLATVPS LEATTTPGIF LLLTPPTTNP HFFPFLSLSP YISDLTSELS
QAPPSHIPPP PRHAQQSPEA SQTDSPPVCW GKTGFSLSEL PRESSYDIYR VPSSQSMEDR
GYSPDTRVVR FLKGKSIGLR LAGGNDVGIF VSGVQAGSPA DGQGIQEGDQ ILRVNDVPFQ
NLTREEAVQF LLGLPPGEEM ELVTQRKQDI FWKMVQSRVG DSFYIRTHFE LEPSPPSGLG
FTRGDVFHVL DTLYPGPEQS HTRGGHWLAV RMGRDLREQE QGIIPNQSRW GLLQAPISHG
PLGSFQAGQA APPWWRRGTV LRHGQAASRP EGILLSLTAN GTLILSLCLC PSASFKRPVV
ILGPVADIAM QKLTAEMPDQ FEIAGETPDP LETSTGAVRL IDKHALLDVT PSAIERLNYV
QYYPIVVFFM PESRPALKAL RQWLAPASRR STRRLYAQAQ KLRKHSSHLF TATIPLNGTS
DTWYQELKAI IREQQTRPIW TAEDQLEGSL EDNLDLPHRG LADSSADLSC DSRVNSDYET
DGEGGAYTDG EGYTDGEGGP YTDMDDEPPA PALARSSEPV QADEPQSPRD RGRILAHQGA
QVDSSHPQGQ WRQDSVRTYE REALKKKFTR VRDAESSDEE GYDWGPATDL
//
