ID A0A2K6BD47_MACNE Unreviewed; 336 AA.
AC A0A2K6BD47;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=Homeobox D11 {ECO:0000313|Ensembl:ENSMNEP00000009338.1};
GN Name=HOXD11 {ECO:0000313|Ensembl:ENSMNEP00000009338.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000009338.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000009338.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis.
CC {ECO:0000256|ARBA:ARBA00003263}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the Abd-B homeobox family.
CC {ECO:0000256|ARBA:ARBA00006317}.
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DR AlphaFoldDB; A0A2K6BD47; -.
DR STRING; 9545.ENSMNEP00000009338; -.
DR Ensembl; ENSMNET00000033511.1; ENSMNEP00000009338.1; ENSMNEG00000029127.1.
DR GeneTree; ENSGT00940000161308; -.
DR OMA; CNFFTSV; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000029127; Expressed in colon and 1 other cell type or tissue.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IEA:Ensembl.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR021918; DUF3528.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR PANTHER; PTHR46092; HOMEOBOX PROTEIN HOX-A11-RELATED; 1.
DR PANTHER; PTHR46092:SF2; HOMEOBOX PROTEIN HOX-D11; 1.
DR Pfam; PF12045; DUF3528; 2.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000233120}.
FT DOMAIN 262..322
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 264..323
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 74..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 177..267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 186..204
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 336 AA; 35603 MW; 227CEE7F699A5426 CRC64;
MNDFDECGPS AASMYLPGCA YYVAPSDFAS KPSFLSQPSS CQMTFPYSSN LAPHVQPVRE
VAFRDYGLER AKWPYRGGGG GGSAGGGSSG GGPDGAARRG ATLPTTRQPR RQRGAAAAEE
AAMQRELLPP AGRRPDVLFK APEPVCAAPG PPHGPAGAAS NFYSAVGRNG ILPQGFDQFY
EAAPGPPFAG PQPPPPPAPP QPEGAADKGD PKTGAGGSGG SPCAKATTGS EPKGAAEGSG
GDGEGPPVEA GAEKSGGAVA PQRSRKKRCP YTKYQIRELE REFFFNVYIN KEKRLQLSRM
LNLTDRQVKI WFQNRRMKEK KLNRDRLQYF TGNPLF
//
