ID A0A2K6BDE0_MACNE Unreviewed; 359 AA.
AC A0A2K6BDE0;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Src kinase-associated phosphoprotein 2 {ECO:0000256|ARBA:ARBA00039671};
DE AltName: Full=Src family-associated phosphoprotein 2 {ECO:0000256|ARBA:ARBA00041593};
GN Name=SKAP2 {ECO:0000313|Ensembl:ENSMNEP00000009418.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000009418.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000009418.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: May be involved in B-cell and macrophage adhesion processes.
CC In B-cells, may act by coupling the B-cell receptor (BCR) to integrin
CC activation. May play a role in src signaling pathway.
CC {ECO:0000256|ARBA:ARBA00037321}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the SKAP family.
CC {ECO:0000256|ARBA:ARBA00005864}.
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DR RefSeq; XP_011729527.1; XM_011731225.1.
DR AlphaFoldDB; A0A2K6BDE0; -.
DR STRING; 9545.ENSMNEP00000009418; -.
DR Ensembl; ENSMNET00000033591.1; ENSMNEP00000009418.1; ENSMNEG00000029161.1.
DR GeneID; 105475739; -.
DR KEGG; mni:105475739; -.
DR CTD; 8935; -.
DR GeneTree; ENSGT00390000017856; -.
DR OMA; ASDRCDK; -.
DR OrthoDB; 2968233at2759; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000029161; Expressed in bone marrow and 12 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0042113; P:B cell activation; IEA:UniProtKB-KW.
DR CDD; cd13381; PH_Skap-hom_Skap2; 1.
DR CDD; cd12045; SH3_SKAP2; 1.
DR Gene3D; 6.10.250.220; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR037781; SKAP_fam.
DR PANTHER; PTHR15129:SF2; SRC KINASE-ASSOCIATED PHOSPHOPROTEIN 2; 1.
DR PANTHER; PTHR15129; SRC-ASSOCIATED ADAPTOR PROTEIN; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00233; PH; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW B-cell activation {ECO:0000256|ARBA:ARBA00022936};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 116..219
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 297..358
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 66..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 264..293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 273..292
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 359 AA; 41233 MW; 5AA2BC9362F04657 CRC64;
MPNPSSTSSP YPLPEEIRNL LADVETFVAD TLKGENLSKK AKEKRESLIK KIKDVKSVYL
QEFQDKGDAE DGEEYDDPFA GPPDTISLAS ERYDKDDETP SDGAQFPPIA AQDLPFVLKA
GYLEKRRKDH SFLGFEWQKR WCALSKTVFY YYGSDKDKQQ KGEFALDGYS VRMNNTLRKD
GKKDCCFEIS APDKRIYQFT AASPKDAEEW VQQLKFVLQD MESDIIPEDY DERGELYDDV
DHPLPISNPP TSSQPIDDEI YEELPEEEED SAPVKVEEQR KMSQDSVHHT SGDKSTDYAN
FYQGLWDCTG AFSDELSFKR GDVIYILSKE YNRYGWWVGE MKGVIGLVPK AYIMEMYDI
//
