ID A0A2K6BE84_MACNE Unreviewed; 223 AA.
AC A0A2K6BE84;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Vacuolar protein sorting-associated protein 28 homolog {ECO:0000256|PIRNR:PIRNR017535};
GN Name=VPS28 {ECO:0000313|Ensembl:ENSMNEP00000009708.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000009708.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000009708.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Component of the ESCRT-I complex (endosomal sorting complex
CC required for transport I), a regulator of vesicular trafficking
CC process. {ECO:0000256|PIRNR:PIRNR017535}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the VPS28 family.
CC {ECO:0000256|PIRNR:PIRNR017535, ECO:0000256|PROSITE-ProRule:PRU00642}.
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DR AlphaFoldDB; A0A2K6BE84; -.
DR STRING; 9545.ENSMNEP00000009708; -.
DR Ensembl; ENSMNET00000033883.1; ENSMNEP00000009708.1; ENSMNEG00000029258.1.
DR GeneTree; ENSGT00390000007486; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000029258; Expressed in lung and 12 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005769; C:early endosome; IEA:Ensembl.
DR GO; GO:0000813; C:ESCRT I complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0043130; F:ubiquitin binding; IEA:Ensembl.
DR GO; GO:0032509; P:endosome transport via multivesicular body sorting pathway; IEA:InterPro.
DR GO; GO:0036258; P:multivesicular body assembly; IEA:UniProt.
DR GO; GO:0031397; P:negative regulation of protein ubiquitination; IEA:Ensembl.
DR GO; GO:0045732; P:positive regulation of protein catabolic process; IEA:Ensembl.
DR GO; GO:2000397; P:positive regulation of ubiquitin-dependent endocytosis; IEA:Ensembl.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0043162; P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IEA:Ensembl.
DR Gene3D; 1.20.120.1130; -; 2.
DR Gene3D; 1.20.1440.200; -; 1.
DR InterPro; IPR037202; ESCRT_assembly_dom.
DR InterPro; IPR007143; Vps28.
DR InterPro; IPR017899; VPS28_C.
DR InterPro; IPR037206; VPS28_C_sf.
DR InterPro; IPR017898; VPS28_N.
DR InterPro; IPR038358; VPS28_N_sf.
DR PANTHER; PTHR12937; VACUOLAR PROTEIN SORTING 28, ISOFORM 2 VPS28; 1.
DR PANTHER; PTHR12937:SF0; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 28 HOMOLOG; 1.
DR Pfam; PF03997; VPS28; 2.
DR PIRSF; PIRSF017535; VPS28; 2.
DR SUPFAM; SSF140111; Endosomal sorting complex assembly domain; 1.
DR SUPFAM; SSF140427; VPS28 C-terminal domain-like; 1.
DR PROSITE; PS51310; VPS28_C; 1.
DR PROSITE; PS51313; VPS28_N; 1.
PE 3: Inferred from homology;
KW Endosome {ECO:0000256|ARBA:ARBA00022753, ECO:0000256|PIRNR:PIRNR017535};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR017535};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR017535}.
FT DOMAIN 1..98
FT /note="VPS28 N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51313"
FT DOMAIN 102..222
FT /note="VPS28 C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51310"
SQ SEQUENCE 223 AA; 25367 MW; A89FECE4B1182557 CRC64;
SGLAPGPIDR CVLRYDNMAE LFAVVKTMQA WRKHIKDCVS PSEYTAACSR LLCSNKAAFR
QVQGSEISTI DEFCRKFRLD CPLAMERIKE DRPITIKDDK GNLNRCIADV VSLFITVMDK
LRLEIRAMDE IQPDLRELME TMHRMSHLPP DFEGRQTVSQ WWVSLPARQS PRGAQRPSPP
ALAHPTCPVL GMSASDELDD SQVRPMLFDL ESAYNAFNRF LHA
//
