ID A0A2K6BIR3_MACNE Unreviewed; 82 AA.
AC A0A2K6BIR3;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Cystatin-B {ECO:0000256|ARBA:ARBA00040677};
DE AltName: Full=Stefin-B {ECO:0000256|ARBA:ARBA00041437};
GN Name=CSTB {ECO:0000313|Ensembl:ENSMNEP00000011276.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000011276.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000011276.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: This is an intracellular thiol proteinase inhibitor. Tightly
CC binding reversible inhibitor of cathepsins L, H and B.
CC {ECO:0000256|ARBA:ARBA00037154}.
CC -!- SUBUNIT: Able to form dimers stabilized by noncovalent forces.
CC {ECO:0000256|ARBA:ARBA00038678}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the cystatin family.
CC {ECO:0000256|ARBA:ARBA00009403}.
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DR AlphaFoldDB; A0A2K6BIR3; -.
DR Ensembl; ENSMNET00000035459.1; ENSMNEP00000011276.1; ENSMNEG00000029992.1.
DR GeneTree; ENSGT00940000154826; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000029992; Expressed in lung and 12 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IEA:InterPro.
DR CDD; cd00042; CY; 1.
DR Gene3D; 3.10.450.10; -; 1.
DR InterPro; IPR000010; Cystatin_dom.
DR InterPro; IPR046350; Cystatin_sf.
DR InterPro; IPR018073; Prot_inh_cystat_CS.
DR InterPro; IPR001713; Prot_inh_stefin.
DR PANTHER; PTHR11414; CYSTATIN FAMILY MEMBER; 1.
DR PANTHER; PTHR11414:SF22; CYSTATIN-B; 1.
DR Pfam; PF00031; Cystatin; 1.
DR PRINTS; PR00295; STEFINA.
DR SMART; SM00043; CY; 1.
DR SUPFAM; SSF54403; Cystatin/monellin; 1.
DR PROSITE; PS00287; CYSTATIN; 1.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120}.
FT DOMAIN 1..82
FT /note="Cystatin"
FT /evidence="ECO:0000259|SMART:SM00043"
SQ SEQUENCE 82 AA; 9025 MW; AF7FB2DE51A5165E CRC64;
MMCGAPSVVQ PATAETQDIA DQVRSQLEEK ENKKFPVFKA VSFKSQVVAG TNYFIKVQCW
EGPPQTGAGR KPPAQAWALW SQ
//
