ID   A0A2K6BJ31_MACNE        Unreviewed;      1572 AA.
AC   A0A2K6BJ31;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   SubName: Full=Talin 2 {ECO:0000313|Ensembl:ENSMNEP00000011400.1};
GN   Name=TLN2 {ECO:0000313|Ensembl:ENSMNEP00000011400.1};
OS   Macaca nemestrina (Pig-tailed macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000011400.1, ECO:0000313|Proteomes:UP000233120};
RN   [1] {ECO:0000313|Ensembl:ENSMNEP00000011400.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   Ensembl; ENSMNET00000035583.1; ENSMNEP00000011400.1; ENSMNEG00000028802.1.
DR   GeneTree; ENSGT00940000154699; -.
DR   Proteomes; UP000233120; Unplaced.
DR   Bgee; ENSMNEG00000028802; Expressed in adult mammalian kidney and 12 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   CDD; cd12150; talin-RS; 1.
DR   Gene3D; 1.20.120.230; Alpha-catenin/vinculin-like; 3.
DR   Gene3D; 1.20.1410.10; I/LWEQ domain; 1.
DR   Gene3D; 1.20.1420.10; Talin, central domain; 6.
DR   InterPro; IPR036723; Alpha-catenin/vinculin-like_sf.
DR   InterPro; IPR035964; I/LWEQ_dom_sf.
DR   InterPro; IPR002558; ILWEQ_dom.
DR   InterPro; IPR037438; Talin1/2-RS.
DR   InterPro; IPR049108; Talin_R4.
DR   InterPro; IPR015009; Vinculin-bd_dom.
DR   PANTHER; PTHR19981; TALIN; 1.
DR   PANTHER; PTHR19981:SF34; TALIN-2; 1.
DR   Pfam; PF01608; I_LWEQ; 1.
DR   Pfam; PF21692; Talin_R4; 1.
DR   Pfam; PF08913; VBS; 1.
DR   SMART; SM00307; ILWEQ; 1.
DR   SUPFAM; SSF47220; alpha-catenin/vinculin-like; 5.
DR   SUPFAM; SSF109885; I/LWEQ domain; 2.
DR   PROSITE; PS50945; I_LWEQ; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233120}.
FT   DOMAIN          1324..1563
FT                   /note="I/LWEQ"
FT                   /evidence="ECO:0000259|PROSITE:PS50945"
FT   COILED          82..109
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1531..1558
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1572 AA;  165159 MW;  651C66A104CDCE59 CRC64;
     WYVLEVFAAS RGSWLGGIPV CAGVMRANCT LSPSSNLSAV PTVSDQAAAM QLSQCAKNLA
     TSLAELRTAS QKAHEACGPM EIDSALNTVQ TLKNELQDAK MAAVESQLKP LPGETLEKCA
     QDLGSTSKAV GSSMAQLLTC AAQGNEHYTG VAARETAQAL KTLAQAARGV AASTTDPAAA
     HAMLDSARDV MEGSAMLIQE AKQALIAPGD AESQQRLAQV AKAVSHSLNN CVNCLPGQKD
     VDVALKSIGE SSKKLLVDSL PPSTKPFQEA QSELNQAAAD LNQSAGEVVH ATRGQSGELA
     AASGKFSDDF DEFLDAGIEM AGQAQTKEDQ IQVIGNLKNI SMASSKLLLA AKSLSVDPGA
     PNAKNLLAAA ARAVTESINQ LITLCTQQAP GQKECDNALR ELETVKGMLD NPNEPVSDLS
     YFDCIESVME NSKVLGESMA GISQNAKTGD LPAFGECVGI ASKALCGLTE AAAQAAYLVG
     ISDPNSQAGH QGLVDPIQFA RANQAIQMAC QNLVDPGSSP SQVLSAATIV AKHTSALCNA
     CRIASSKTAN PVAKRHFVQS AKEVANSTAN LVKTIKALDG DFSEDNRSKC HMATAPLIEA
     VENLTAFASN PEFVSIPAQI SSEGSQAQEP ILVSAKTMLE SSSYLIRTAR SLAINPKDPP
     TWSVLAGHSH TVSDSIKSLI TSIRDKAPGQ RECDYSIDGI NRCIRDIEQA SLAAVSQSLA
     TRDDISVEAL QEQLTSVVQE IGHLIDPIAT AARGEAAQLG HKVTQLASYF EPLILAAVGV
     ASKILDHQQQ MTVLDQTKTL AESALQMLYA AKEGGGNPKA QHTHDAITEA AQLMKEAVDD
     IMVTLNEAAS EVGLVGGMVD AIAEAMSKLD EGTPPEPKGT FVDYQTTVVK YSKAIAVTAQ
     EMMTKSVTNP EELGGLASQM TSDYGHLAFQ GQMAAATAEP EEIGFQIRTR VQDLGHGCIF
     LVQKAGALQV CPTDSYTKRE LIECARAVTE KVSLVLSALQ AGNKGTQACI TAATAVSGII
     ADLDTTIMFA TAGTLNAENS ETFADHRENI LKTAKALVED TKLLVSGAAS TPDKLAQAAQ
     SSAATITQLA EVVKLGAASL GSDDPETQVV LINAIKDVAK ALSDLISATK GAASKPADDP
     SMYQLKGAAK VMVTNVTSLL KTVKAVEDEA TRGTRALEAT IECIKQELTL FQSKDVPEKT
     SSPEESIRMT KGITMATTKA VAAGNSCRQE DVIATANLSR KAVSDMLTAC KQASFHPDVS
     DEVRTRALRF GTECTLGYLD LLEHVLVILQ KPTPELKQQL AAFSKRVAGA VTELIQAAEA
     MKGTEWVDPE DPTVIAETEL LGAAASIEAA AKKLEQLKPR AKPKQADETL DFEEQILEAA
     KSIAAATSAL VKSASAAQRE LVAQGKVGSI PANAADDGQW SQGLISAARM VAAATSSLCE
     AANASVQGHA SEEKLISSAK QVAASTAQLL VACKVKADQD SEAMRRLQAA GNAVKRASDN
     LVRAAQKAAF GKADDDDVVV KTKFVGGIAQ IIAAQEEMLK KERELEEARK KLAQIRQQQY
     KFLPTELRED EG
//