ID   A0A2K6BJQ4_MACNE        Unreviewed;       932 AA.
AC   A0A2K6BJQ4;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1 {ECO:0000313|Ensembl:ENSMNEP00000011630.1};
GN   Name=HUWE1 {ECO:0000313|Ensembl:ENSMNEP00000011630.1};
OS   Macaca nemestrina (Pig-tailed macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000011630.1, ECO:0000313|Proteomes:UP000233120};
RN   [1] {ECO:0000313|Ensembl:ENSMNEP00000011630.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A2K6BJQ4; -.
DR   Ensembl; ENSMNET00000035816.1; ENSMNEP00000011630.1; ENSMNEG00000028305.1.
DR   GeneTree; ENSGT00940000156319; -.
DR   Proteomes; UP000233120; Unplaced.
DR   Bgee; ENSMNEG00000028305; Expressed in skeletal muscle tissue and 12 other cell types or tissues.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR010309; E3_Ub_ligase_DUF908.
DR   InterPro; IPR010314; E3_Ub_ligase_DUF913.
DR   Pfam; PF06012; DUF908; 1.
DR   Pfam; PF06025; DUF913; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000233120}.
FT   DOMAIN          77..353
FT                   /note="DUF908"
FT                   /evidence="ECO:0000259|Pfam:PF06012"
FT   DOMAIN          416..878
FT                   /note="DUF913"
FT                   /evidence="ECO:0000259|Pfam:PF06025"
FT   REGION          490..564
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          770..822
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        490..508
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        509..561
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        801..820
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   932 AA;  102849 MW;  9BDE4040362C290E CRC64;
     LKENCRALID KLKVCNDEQL LLELQQIKTW NIGKCELYHW VDLLDRFDGI LADAGQTVEN
     MSWMLVCDRP EREQLKMLLL AVLNFTALLI EYSFSRHLYS SIEHLTTLLA SSDMQVVLAV
     LNLLYVFSKR SNYITRLGSD KRTPLLTRLQ HLAESWGGKE NGFGLAECCR DLHMMKYPPS
     ATTLHFEFYA DPGAEVKIEK RTTSNTLHYI HIEQLDKISE SPSEIMESLT KMYSIPKDKQ
     MLLFTHIRLA HGFSNHRKRL QAVQARLHAI SILVYSNALQ ESANSILYNG LIEELVDVLQ
     ITDKQLMEIK AASLRTLTSI VHLERTPKLS SIIDCTGTAS YHGFLPVLVR NCIQAMIDPS
     MDPYPHQFAT ALFSFLYHLA SYDAGGEALV SCGMMEALLK VIKFLGDEQD QITFVTRAVR
     VVDLITNLDM AAFQSHSGLS IFIYRLEHEV DLCRKECPFV IKPKIQRPST TQEGEEMETD
     MDVADVAMES SPGSSISMEH STNISSGPSP GPSPGPGPGP GPGPGPGPGP GPGPGPGPGP
     GPGPGPGPGP GPGPGPGPRP GAQCIPQRAA LLKSMLNFLK KAIQDPAFSD GIRHVMDGSL
     PTSLKHIISN AEYYGPSLFL LATEVVTVFV FQEPSLLSSL QDNGLTDVML HALLIKDVPA
     TREVLGSLPN VFSALCLNAR GLQSFVQCQP FERLFKVLLS PDYLPAMRRR RSSDPLGDTA
     SNLGSAVDEL MRHQPTLKTD ATTAIIKLLE EICNLGRDPK YICQKPSIQK ADGTATAPPP
     RSNHAAEEAS SEDEEEEEVQ AMQSFNSTQQ NESEPNQQVV GTEERIPIPL MDYILNVMKF
     VESILSNNTT DDHCQEFVNQ KGLLPLVTIL GLPNLPIDFP TSAACQAVAG VCKSILVRSI
     WPNVFISFWK SILRYFCIYV FTVVSLQLKN NE
//