ID A0A2K6BK06_MACNE Unreviewed; 629 AA.
AC A0A2K6BK06;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE SubName: Full=Nuclear receptor subfamily 2 group C member 2 {ECO:0000313|Ensembl:ENSMNEP00000011732.1};
GN Name=NR2C2 {ECO:0000313|Ensembl:ENSMNEP00000011732.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000011732.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000011732.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004334}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR2
CC subfamily. {ECO:0000256|ARBA:ARBA00006421}.
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DR RefSeq; XP_011732801.1; XM_011734499.1.
DR AlphaFoldDB; A0A2K6BK06; -.
DR STRING; 9545.ENSMNEP00000011732; -.
DR Ensembl; ENSMNET00000035924.1; ENSMNEP00000011732.1; ENSMNEG00000030133.1.
DR GeneTree; ENSGT00940000158393; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000030133; Expressed in thymus and 12 other cell types or tissues.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR CDD; cd06967; NR_DBD_TR2_like; 1.
DR CDD; cd06952; NR_LBD_TR2_like; 1.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR048245; NR2C1/2-like_DBD.
DR InterPro; IPR048246; NR2C1/2-like_LBD.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR24083; NUCLEAR HORMONE RECEPTOR; 1.
DR PANTHER; PTHR24083:SF48; NUCLEAR RECEPTOR SUBFAMILY 2 GROUP C MEMBER 2; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004334};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU004334};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004334};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU004334};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004334};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU004334};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004334};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU004334}.
FT DOMAIN 147..222
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT DOMAIN 374..616
FT /note="NR LBD"
FT /evidence="ECO:0000259|PROSITE:PS51843"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 629 AA; 68993 MW; 4189D7414852856C CRC64;
MATNMEGLVQ HRVGTQQVAE VTRTQTSRPE SPGMTSPSPR IQIISTDSAV ASPQRIQIVT
DQQTGQKIQI VTAVDASGSP KQQFILTSPD GAGTGKVILA SPETSSAKQL IFTTSDNLVP
GRIQIVTDSA SVERLLGKTD VQRPQVVEYC VVCGDKASGR HYGAVSCEGC KGFFKRSVRK
NLTYSCRSNQ DCIINKHHRN RCQFCRLKKC LEMGMKMESV QSERKPFDVQ REKPSNCAAS
TEKIYIRKDL RSPLIATPTF VADKDGARQT GLLDPGMLVN IQQPLIREDG TVLLATDSKA
ETSQGALGTL ANVVTSLANL SESLNNGDTS EIQPEDQSAS EITRAFDTLA KALNTTDSSS
SPSLADGIDT SGGGSIHVIS RDQSTPIIEV EGPLLSDTHV TFKLTMPSPM PEYLNVHYIC
ESASRLLFLS MHWARSIPAF QALGQDCNTS LVRACWNELF TLGLAQCAQV MSLSTILAAI
VNHLQNSIQE DKLSGDRIKQ VMEHIWKLQE FCNSMAKLDI DGYEYAYLKA IVLFSPDHPG
LTSTSQIEKF QEKAQMELQD YVQKTYSEDT YRLARILVRL PALRLMSSNI TEELFFTGLI
GNVSIDSIIP YILKMETAEY NGQITGASL
//
