ID A0A2K6BKE3_MACNE Unreviewed; 1235 AA.
AC A0A2K6BKE3;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Jumonji and AT-rich interaction domain containing 2 {ECO:0000313|Ensembl:ENSMNEP00000011848.1};
GN Name=JARID2 {ECO:0000313|Ensembl:ENSMNEP00000011848.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000011848.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000011848.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A2K6BKE3; -.
DR Ensembl; ENSMNET00000036041.1; ENSMNEP00000011848.1; ENSMNEG00000030214.1.
DR GeneTree; ENSGT00940000159220; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000030214; Expressed in thymus and 12 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR CDD; cd16870; ARID_JARD2; 1.
DR Gene3D; 1.10.150.60; ARID DNA-binding domain; 1.
DR Gene3D; 2.60.120.650; Cupin; 1.
DR InterPro; IPR001606; ARID_dom.
DR InterPro; IPR036431; ARID_dom_sf.
DR InterPro; IPR003347; JmjC_dom.
DR InterPro; IPR003349; JmjN.
DR InterPro; IPR004198; Znf_C5HC2.
DR PANTHER; PTHR10694; LYSINE-SPECIFIC DEMETHYLASE; 1.
DR PANTHER; PTHR10694:SF113; PROTEIN JUMONJI; 1.
DR Pfam; PF01388; ARID; 1.
DR Pfam; PF02373; JmjC; 1.
DR Pfam; PF02375; JmjN; 1.
DR Pfam; PF02928; zf-C5HC2; 1.
DR SMART; SM01014; ARID; 1.
DR SMART; SM00501; BRIGHT; 1.
DR SMART; SM00558; JmjC; 1.
DR SMART; SM00545; JmjN; 1.
DR SUPFAM; SSF46774; ARID-like; 1.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR PROSITE; PS51011; ARID; 1.
DR PROSITE; PS51184; JMJC; 1.
DR PROSITE; PS51183; JMJN; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120}.
FT DOMAIN 546..587
FT /note="JmjN"
FT /evidence="ECO:0000259|PROSITE:PS51183"
FT DOMAIN 610..702
FT /note="ARID"
FT /evidence="ECO:0000259|PROSITE:PS51011"
FT DOMAIN 873..1037
FT /note="JmjC"
FT /evidence="ECO:0000259|PROSITE:PS51184"
FT REGION 32..139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 166..328
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 344..537
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1197..1235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..64
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 73..88
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 103..119
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..183
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..253
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 290..306
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 356..388
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 416..444
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 468..491
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 510..524
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1220..1235
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1235 AA; 137194 MW; 7093E6C9A6A0194D CRC64;
MFLQDDSDGI PWSEERVVRK VLYLSLKEFK NAQKRQHGEG LAGSLKTVNG LLGNDQSKGL
GPASEQSENE KDDASQVSST SNDVSSSDFE EGPSRKRPRL QAQRKFAQSQ PNSPSTTPVK
IVEPLLPPPA TQISDLSKRK PKTEDFLTFL CLRGSPALPN SMVYFGSSQD EEEVEEEDDE
TEDVKTATNN ASSSCQSTPR KGKTHKHVHN GHVFNGSSRS TREKEPVQKH KSKEATPAKE
KHSDHRADSR REQASANHPA AAPSTGSSAK GPAANHHHPP LHRSAQDLRK QVSKVNGVTR
MSSLGAGATS AKKMREVRPS PSKTVKYTAT VTKGAVTYTK AKRELVKDTK PNHHKPSSAV
NHTISGKTES SNAKTRKQVL SLGGASKSTG PAVNGLKVSG RLNPKSCTKE VGGRQLREGL
QLREGLRNSK RRLEEAHQAE KPQSPPKKMK GAAGPAEGPG KKAPAEKGLL NGHVKKEVPE
RSLERNRPKR ATAGKSTPGR QAHGKADGAS CENRSTSQPE SVHKSQDSGK AEKGGGKAGW
AAMDEIPVLR PSAKEFHDPL IYIESVRAQV EKFGMCRVIP PPDWRPECKL NDEMRFVTQI
QHIHKLGRRW GPNVQRLACI KKHLKSQGIT MDELPLIGGC ELDLACFFRL INEMGGMQQV
TDLKKWNKLA DMLRIPRTAQ DRLAKLQEAY CQYLLSYDSL SPEEHRRLEK EVLMEKEILE
KRKGPLEGHT ENDHHKFHPL PRFEPKNGLI HGVAPRNGFR SKLKEVGQAQ LKTGRRRLFA
QEKEVVKEEE EDKGVLNDFH KCIYKGRSVS LTTFYRTARN IMSMCFSKEP APAEIEQEYW
RLVEEKDCHV AVHCGKVDTN THGSGFPVGK SEPFSRHGWN LTVLPNNTGS ILRHLGAVPG
VTIPWLNIGM VFSTSCWSRD QNHLPYIDYL HTGADCIWYC IPAEEENKLE DVVHTLLQAN
GTPGLQMLES NVMISPEVLC KEGIKVHRTV QQSGQFVVCF PGSFVSKVCC GYSVSETVHF
ATTQWTSMGF ETAKEMKRRH IAKPFSMEKL LYQIAQAEAK KENGPTLSTI SALLDELRDT
ELRQRRQLFE AGLHSSARYG SHDGSSTVAD GKKKPRKWLQ LETSERRCQI CQHLCYLSMV
VQENENVVFC LECALRHVEK QKSCRGLKLM YRYDEEQIIS LVNQICGKVS GKNGSIENCL
SKPTPKRGPR KRATVDVPPS RLSASGSSKS ASSSS
//
