ID   A0A2K6BKX0_MACNE        Unreviewed;       606 AA.
AC   A0A2K6BKX0;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   RecName: Full=Integrator complex subunit 11 {ECO:0000256|ARBA:ARBA00016810};
DE   AltName: Full=Cleavage and polyadenylation-specific factor 3-like protein {ECO:0000256|ARBA:ARBA00029625};
GN   Name=INTS11 {ECO:0000313|Ensembl:ENSMNEP00000012041.1};
OS   Macaca nemestrina (Pig-tailed macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000012041.1, ECO:0000313|Proteomes:UP000233120};
RN   [1] {ECO:0000313|Ensembl:ENSMNEP00000012041.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the metallo-beta-lactamase superfamily. RNA-
CC       metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.
CC       {ECO:0000256|ARBA:ARBA00007093}.
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DR   AlphaFoldDB; A0A2K6BKX0; -.
DR   Ensembl; ENSMNET00000036235.1; ENSMNEP00000012041.1; ENSMNEG00000030021.1.
DR   GeneTree; ENSGT00940000157644; -.
DR   Proteomes; UP000233120; Unplaced.
DR   Bgee; ENSMNEG00000030021; Expressed in cerebellum and 12 other cell types or tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   CDD; cd16291; INTS11-like_MBL-fold; 1.
DR   Gene3D; 3.40.50.10890; -; 1.
DR   Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR   InterPro; IPR022712; Beta_Casp.
DR   InterPro; IPR041897; INTS11-like_MBL-fold.
DR   InterPro; IPR048662; IntS11_C.
DR   InterPro; IPR001279; Metallo-B-lactamas.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   InterPro; IPR011108; RMMBL.
DR   PANTHER; PTHR11203; CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER; 1.
DR   PANTHER; PTHR11203:SF37; INTEGRATOR COMPLEX SUBUNIT 11; 1.
DR   Pfam; PF10996; Beta-Casp; 1.
DR   Pfam; PF21386; IntS11_C; 1.
DR   Pfam; PF16661; Lactamase_B_6; 1.
DR   Pfam; PF07521; RMMBL; 1.
DR   SMART; SM01027; Beta-Casp; 1.
DR   SMART; SM00849; Lactamase_B; 1.
DR   SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000233120}.
FT   DOMAIN          22..239
FT                   /note="Metallo-beta-lactamase"
FT                   /evidence="ECO:0000259|SMART:SM00849"
FT   DOMAIN          251..369
FT                   /note="Beta-Casp"
FT                   /evidence="ECO:0000259|SMART:SM01027"
SQ   SEQUENCE   606 AA;  68338 MW;  4FED9B2CAD95D05F CRC64;
     MCGAGFGRFR WLVGEGAGQD VGRSCILVSI AGKNVMLDCG MHMGFNDDRR FPDFSYITQN
     GRLTDFLDCV IISHFHLDHC GALPYFSEMV GYDGPIYMTH PTQAICPILL EDYRKIAVDK
     KGEANFFTSQ MIKDCMKKVV AVHLHQTVQV DDELEIKAYY AGHVLGAAMF QIKVGSESVV
     YTGDYNMTPD RHLGAAWIDK CRPNLLITES TYATTIRDSK RCRERDFLKK VHETVERGGK
     VLIPVFALGR AQELCILLET FWERMNLKVP IYFSTGLTEK ANHYYKLFIP WTNQKIRKTF
     VQRNMFEFKH IKAFDRAFAD NPGPMVVFAT PGMLHAGQSL QIFRKWAGNE KNMVIMPGYC
     VQGTVGHKIL SGQRKLEMEG RQVLEVKMQV EYMSFSAHAD AKGIMQLVGQ AEPESVLLVH
     GEAKKMEFLK QKIEQELRVS CYMPANGETV TLPTSPSIPV GISLGLLKRE MVQGLLPEAK
     KPRLLHGTLI MKDSNFRLVS SEQALKELGL AEHQLRFTCR VHLHDTRKEQ EMALRVYSHL
     KSVLKDHCVQ HLPDGSVTVE SILIQAAAPS EDPGTKVLLV SWTYQDEELG SFLTSLLKKG
     LPQAPS
//