ID   A0A2K6BP63_MACNE        Unreviewed;       125 AA.
AC   A0A2K6BP63;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 31.
DE   SubName: Full=Interferon induced transmembrane protein 1 {ECO:0000313|Ensembl:ENSMNEP00000013167.1};
GN   Name=IFITM1 {ECO:0000313|Ensembl:ENSMNEP00000013167.1};
OS   Macaca nemestrina (Pig-tailed macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000013167.1, ECO:0000313|Proteomes:UP000233120};
RN   [1] {ECO:0000313|Ensembl:ENSMNEP00000013167.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the CD225/Dispanin family.
CC       {ECO:0000256|ARBA:ARBA00006843}.
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DR   RefSeq; XP_011760555.1; XM_011762253.1.
DR   AlphaFoldDB; A0A2K6BP63; -.
DR   STRING; 9545.ENSMNEP00000013167; -.
DR   Ensembl; ENSMNET00000037366.1; ENSMNEP00000013167.1; ENSMNEG00000030846.1.
DR   GeneID; 105494126; -.
DR   KEGG; mni:105494126; -.
DR   CTD; 8519; -.
DR   GeneTree; ENSGT00950000182857; -.
DR   OMA; LYANVCC; -.
DR   OrthoDB; 5322528at2759; -.
DR   Proteomes; UP000233120; Unplaced.
DR   Bgee; ENSMNEG00000030846; Expressed in lymph node and 12 other cell types or tissues.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR   GO; GO:0030336; P:negative regulation of cell migration; IEA:Ensembl.
DR   GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR   GO; GO:0046597; P:negative regulation of viral entry into host cell; IEA:Ensembl.
DR   GO; GO:0045071; P:negative regulation of viral genome replication; IEA:Ensembl.
DR   GO; GO:0045669; P:positive regulation of osteoblast differentiation; IEA:Ensembl.
DR   GO; GO:0035455; P:response to interferon-alpha; IEA:Ensembl.
DR   GO; GO:0035456; P:response to interferon-beta; IEA:Ensembl.
DR   GO; GO:0034341; P:response to type II interferon; IEA:Ensembl.
DR   GO; GO:0009615; P:response to virus; IEA:Ensembl.
DR   InterPro; IPR007593; CD225/Dispanin_fam.
DR   PANTHER; PTHR13999; INTERFERON INDUCIBLE TRANSMEMBRANE PROTEIN; 1.
DR   PANTHER; PTHR13999:SF6; INTERFERON-INDUCED TRANSMEMBRANE PROTEIN 1; 1.
DR   Pfam; PF04505; CD225; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        37..59
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        89..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   125 AA;  13945 MW;  57C4B89AB94A5FEF CRC64;
     MHKEEHEVSV LGAPHSTILP RSTMINIQSE TSVPDHIVWS LFNTIFLNWC CLGFIAFAYS
     VKSRDRKMVG DVTGAQAYAS TAKCLNISAL IVGILMTIGF ILLLVFGSVA IYHVMLQIVQ
     EKQRY
//