ID A0A2K6BPU1_MACNE Unreviewed; 324 AA.
AC A0A2K6BPU1;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Nuclear receptor subfamily 1 group I member 3 {ECO:0000256|ARBA:ARBA00040912};
DE AltName: Full=Constitutive androstane receptor {ECO:0000256|ARBA:ARBA00043125};
GN Name=NR1I3 {ECO:0000313|Ensembl:ENSMNEP00000013387.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000013387.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000013387.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Binds and transactivates the retinoic acid response elements
CC that control expression of the retinoic acid receptor beta 2 and
CC alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital
CC responsive element module of the human CYP2B6 gene and the CYP3A4
CC xenobiotic response element. {ECO:0000256|ARBA:ARBA00037362}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
CC subfamily. {ECO:0000256|ARBA:ARBA00008092}.
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DR AlphaFoldDB; A0A2K6BPU1; -.
DR Ensembl; ENSMNET00000037587.1; ENSMNEP00000013387.1; ENSMNEG00000030882.1.
DR GeneTree; ENSGT00940000160641; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000030882; Expressed in liver and 3 other cell types or tissues.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProt.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR24082; NUCLEAR HORMONE RECEPTOR; 1.
DR PANTHER; PTHR24082:SF231; NUCLEAR RECEPTOR SUBFAMILY 1 GROUP I MEMBER 3; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 1..54
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT DOMAIN 80..324
FT /note="NR LBD"
FT /evidence="ECO:0000259|PROSITE:PS51843"
SQ SEQUENCE 324 AA; 36911 MW; 0ACDEE1E70187A01 CRC64;
ILPKISRRTV SKSIGPTCPF AGSCEVSKIQ RRHCPACRLQ KCLDAGMRKD MILSAEALAL
RRAKQAQRRA QQTPMQLSNE QEELIQTLLG AHTRHMGTMF EQFVQFRPPA HLFIHHQPLP
TLAPVLPLVT HFADVNTFMV QQVIKFTKDL PVFRSLPIED QISLLKGAAV EICHIVLNTT
FCLQTQNFLC GPLRYTIEDA ARVGFQVEFL ELLFHFHGTL RKLQLQEPEY VLLAAMALFS
PAPYLTDRPG VTQRHEIDQL QEEMALTLQS YIKGQQQRPR DRFLYAKLLG LLAELRSINE
AYGYQIQHIQ GLSAMMPLLQ EICS
//
