ID A0A2K6BQC3_MACNE Unreviewed; 1815 AA.
AC A0A2K6BQC3;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Golgi brefeldin A resistant guanine nucleotide exchange factor 1 {ECO:0000313|Ensembl:ENSMNEP00000013577.1};
GN Name=GBF1 {ECO:0000313|Ensembl:ENSMNEP00000013577.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000013577.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000013577.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000256|ARBA:ARBA00004555}.
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DR STRING; 9545.ENSMNEP00000013577; -.
DR Ensembl; ENSMNET00000037778.1; ENSMNEP00000013577.1; ENSMNEG00000030880.1.
DR GeneTree; ENSGT00940000156925; -.
DR OMA; CRDIRHH; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000030880; Expressed in skeletal muscle tissue and 12 other cell types or tissues.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0051641; P:cellular localization; IEA:UniProt.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProt.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.220.20; -; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR032691; Mon2/Sec7/BIG1-like_HUS.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663:SF388; GOLGI-SPECIFIC BREFELDIN A-RESISTANCE GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF01369; Sec7; 1.
DR Pfam; PF12783; Sec7-like_HUS; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120}.
FT DOMAIN 648..838
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT REGION 171..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 237..329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 572..632
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1242..1286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1389..1439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1700..1764
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 202..221
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 237..289
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 614..632
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1256..1274
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1733..1749
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1750..1764
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1815 AA; 201562 MW; B7514EA96DF8AE08 CRC64;
MVDKNIYIIQ GEINIVVGAI KRNARWSTHT PLDEERDPLL HSFGHLKEVL NNITDPTHEG
TAEGMENMAD AVTHARFVGT DPASDEVVLM KILQVLRTLL LTPVGAHLTN ESVCEIMQSC
FRICFEMRLS ELLRKSAEHT LVDMVQLLFT RLPQFKEEPK NYVGTNMKKL KMRAGGMSDS
SKWKKQKRSP RPPRHMTKVT PGSELPTPNG TTLSSNLTGG MPFIDVPTPI SSASSEAASA
VVSPSTDSGL EFSSQTTSKE DLTDLEQPGS PGYSTATEPG SSELGVPEQS DLQEGTHVEK
SQSASVESIP EVLEECTSPA DHSDSASVHD MDYVNPRGVR FTQSSQKEGT ALVPYGLPCI
RELFRFLISL TNPHDRHNSE VMIHMGLHLL TVALESAPVA QCQTLLGLIK DEMCRHLFQL
LSIERLNLYA ASLRVCFLLF ESMREHLKFQ MEMYIKKLME IITVENPKMP YEMKEMALEA
IVQLWRIPSF VTELYINYDC DYYCSNLFED LTKLLSKNAF PVSGQLYTTH LLSLDALLTV
IDSTEAHCQA KVLNSITQQE KKETARPSCE IVDGTREASN TERAASDGKA VGMASDIPGL
HLPGGGRLPP EHGKPGCSDL EEAGDSGADK KFARKPPRFS CLLPDPRELI EIKNKKKLLI
TGTEQFNQKP KKGIQFLQEK GLLTIPMDNT EVAQWLRENP RLDKKMIGEF VSDRKNIDLL
ESFVSTFSFQ GLRLDEALRL YLEAFRLPGE APVIQRLLEA FTERWMNCNG SPFANSDACF
SLAYAVIMLN TDQHNHNVRK QNAPMTLEEF RKNLKGVNGG KDFEQDILED MYHAIKNEEI
VMPEEQTGLV RENYVWNVLL HRGATPEGIF LRVPTASYDL DLFTMTWGPT IAALSYVFDK
SLEETIIQKA ISGFRKCAMI SAHYGLSDVF DNLIISLCKF TALSSESIEN LPSVFGSNPK
AHIAAKTVFH LAHRHGDILR EGWKNIMEAM LQLFRAQLLP KAMVEVEDFV DPNGKISLQR
EETPSNRGES TVLSFVSWLT LSGPEQSSVR GPSTENQEAK RVALECIKQC DPEKMITESK
FLQLESLQEL MKALVSVTPD EETYDEEDAA FCLEMLLRIV LENRDRVGCV WQTVRDHLYH
LCVQAQDFCF LVERAVVGLL RLAIRLLRRE EISGQVLLSL RILLLMKPSV LSRVSHQVAY
GLHELLKTNA ANIHSGDDWA TLFTLLECIG SGVKPPATLQ ATARADAPDA GAQSDSELPS
YHQNDVSLDR GYTSDSEVYT DHARPGKIHR SATDADVVNS GWLVVGKDDI DNSKPGPSRP
GPSPLINQYS LTVGLDLGPH DTKSLLKCVE SLSFIVRDAA HITPDNFELC VKTLRIFVEA
SLNGGCKCQE KRGKSHKYDS KGNRFKKKSK EGSMLRRPRT SSQHASRGGQ SDDDEDEGVP
ASYHTVSLQV SQDLLDLMHT LHTRAASIYS SWAEEQRHLE TDGQKIEADS RTLWAHCWCP
LLQGIACLCC DARRQVRMQA LTYLQRALLV HDLQKLDALE WESCFNKVLF PLLTKLLENI
SPADVGGMEE TRMRASTLLS KVFLQHLSPL LSLSTFAALW LTILDFMDKY MHAGSSDLLS
EAIPESLKNM LLVMDTAEIF HSADARGGGP SALWEITWER IDCFLPHLRD ELFKQTVIQD
PMPMEPHGPK PLASAHLTSA AGDTRTPGHP PPPEIPSELG ACDFEKPEGP RAASSSSPGS
PVASSPSRLS PTPDGPPPLA QPPLILQPLA SPLQVGVPPM TLPIILNPAL IEATSPVPLL
ATPRPTDPIP TSEVN
//
