ID A0A2K6BQY2_MACNE Unreviewed; 881 AA.
AC A0A2K6BQY2;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Exocyst complex component 1 {ECO:0000313|Ensembl:ENSMNEP00000013808.1};
GN Name=EXOC1 {ECO:0000313|Ensembl:ENSMNEP00000013808.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000013808.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000013808.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the SEC3 family.
CC {ECO:0000256|ARBA:ARBA00006518}.
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DR AlphaFoldDB; A0A2K6BQY2; -.
DR Ensembl; ENSMNET00000038010.1; ENSMNEP00000013808.1; ENSMNEG00000030837.1.
DR GeneTree; ENSGT00940000158640; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000030837; Expressed in temporal lobe and 12 other cell types or tissues.
DR GO; GO:0000145; C:exocyst; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR CDD; cd14683; PH-EXOC1; 1.
DR Gene3D; 2.30.29.90; -; 1.
DR InterPro; IPR028258; Sec3-PIP2_bind.
DR InterPro; IPR048628; Sec3_C.
DR InterPro; IPR019160; Sec3_CC.
DR PANTHER; PTHR16092:SF33; EXOCYST COMPLEX COMPONENT 1; 1.
DR PANTHER; PTHR16092; SEC3/SYNTAXIN-RELATED; 1.
DR Pfam; PF15277; Sec3-PIP2_bind; 1.
DR Pfam; PF20654; Sec3_C-term; 1.
DR Pfam; PF09763; Sec3_CC; 1.
DR SMART; SM01313; Sec3-PIP2_bind; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Exocytosis {ECO:0000256|ARBA:ARBA00022483};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 541..560
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 31..122
FT /note="Exocyst complex component Sec3 PIP2-binding N-
FT terminal"
FT /evidence="ECO:0000259|SMART:SM01313"
FT REGION 447..486
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 214..262
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 456..486
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 881 AA; 101028 MW; F6490170AF99174A CRC64;
MTAIKHALQR DIFTPNDERL LSIVNVCKAG KKKKNCFLCA TVTTERPVQV KVVKVKKSDK
GDFYKRQIAW ALRDLAVVDA KDAIKENPEF DLHFEKIYKW VASSTAEKNA FISCIWKLNQ
RYLRKKIDFV NVSSQLLEEL PKVTEESVPS GENQSVTGGD EEVVDEYQEL NAREEQDIEI
MMEGCEYAIS NAEAFAEKLS RELQVLDGAN IQSIMASEKQ VNILMKLLDE ALKEVDQIEL
KLSSYEEMLQ SVKEQMDQIS ESNHLIHLSN TNNVKLLSEI EFLVNHMDLA KGHIKALQEG
DLASSRGIEA CTNAADALLQ CMNVALRPGH DMLLAVKQQQ QRFSDLRELF ARRLASHLNN
VFVQQGHDQS STLAQHSVEL TLPNHHPFHR DLLRYAKLME WLKSTDYGKY EGLTKNYMDY
LSRLYEREIK DFFEVAKIKM TGTTKESKKF GLHGSSGKLT GSTSSLNKLS VQSSGNRRSQ
SSSLLDMGNM SASDLDVADR TKFDKIFEQV LSELEPLCLA EQDFISKFFK LQQHQSIPGT
MVWLIVYFAC YNFIYLVCFL NRKDMIRQMM IKIFRCIEPE LNNLIALGDK IDSFNSLYML
VKMSHHVWTA QNVDPASFLS TTLGNVLVTV KRNFDKCISN QIRQMEEVKI SKKSKVGILP
FVAEFEEFAG LAESIFKNAE RRGDLDKAYT KLIRGVFVNV EKVANESQKT PRDVVMMENF
HHIFATLSRL KISCLEAEKK DAKQKYTDHL QSYVIYSLGQ PLEKLNHFFD GVEARVAQGI
REEEVSYQLA FNKQELRKVI KEYPGKEVKK GLDNLYKKVD KHLCEEENLL QVVWHSMQDE
FIRQYKHFEG LIARCYPGSG VTMEFTIQDI LDYCSSIAQS H
//
