ID A0A2K6BUV5_MACNE Unreviewed; 364 AA.
AC A0A2K6BUV5;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE SubName: Full=Growth differentiation factor 3 {ECO:0000313|Ensembl:ENSMNEP00000015180.1};
GN Name=GDF3 {ECO:0000313|Ensembl:ENSMNEP00000015180.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000015180.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000015180.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR RefSeq; XP_011744016.1; XM_011745714.1.
DR AlphaFoldDB; A0A2K6BUV5; -.
DR STRING; 9545.ENSMNEP00000015180; -.
DR Ensembl; ENSMNET00000039388.1; ENSMNEP00000015180.1; ENSMNEG00000031722.1.
DR GeneID; 105484239; -.
DR KEGG; mni:105484239; -.
DR CTD; 9573; -.
DR GeneTree; ENSGT00940000162534; -.
DR OMA; LDVAKDW; -.
DR OrthoDB; 2912454at2759; -.
DR Proteomes; UP000233120; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:0001654; P:eye development; IEA:Ensembl.
DR GO; GO:0030514; P:negative regulation of BMP signaling pathway; IEA:Ensembl.
DR GO; GO:0045605; P:negative regulation of epidermal cell differentiation; IEA:Ensembl.
DR GO; GO:0010453; P:regulation of cell fate commitment; IEA:Ensembl.
DR GO; GO:0001501; P:skeletal system development; IEA:Ensembl.
DR CDD; cd13764; TGF_beta_GDF1_3_like; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF38; GROWTH/DIFFERENTIATION FACTOR 3; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR PRINTS; PR00669; INHIBINA.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..364
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014396720"
FT DOMAIN 247..364
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
SQ SEQUENCE 364 AA; 41323 MW; 54FE888C36BF9FA7 CRC64;
MLRFLPDLAF SFLLTLAFGQ AVQFQEYVFL QFMGLDKAPS PQKFQPVPYI LKKIFQDREA
AATTGVSRDL CYVKELGVRG NVLRFLPDQG FFLYPKKFSQ ASSCLQKLLY FNLSAIKERE
QLTLAQLGLD LGPNSYYNLG PELELALFLV QEPHVWGQTT PKPGKMFVLR SVPWPQGAVH
FNLLDVAKDW NDNSQKNFGL FLEILVKEDR DSGANFQPED TCARLRRSLH ASLLVVALNP
DECPPSRKRR AAIPVPKVSC KNLCHRHQLF INFQDLGWHK WIIAPKGFMA NYCHGECPFS
LTISLNSSNY AFMQALMHAV DPEIPQAVCV PTKLSPISML YQDNNDNVIL RHYEDMVVDE
CGCG
//