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Database: UniProt
Entry: A0A2K6BUV5_MACNE
LinkDB: A0A2K6BUV5_MACNE
Original site: A0A2K6BUV5_MACNE 
ID   A0A2K6BUV5_MACNE        Unreviewed;       364 AA.
AC   A0A2K6BUV5;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 30.
DE   SubName: Full=Growth differentiation factor 3 {ECO:0000313|Ensembl:ENSMNEP00000015180.1};
GN   Name=GDF3 {ECO:0000313|Ensembl:ENSMNEP00000015180.1};
OS   Macaca nemestrina (Pig-tailed macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000015180.1, ECO:0000313|Proteomes:UP000233120};
RN   [1] {ECO:0000313|Ensembl:ENSMNEP00000015180.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the TGF-beta family.
CC       {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR   RefSeq; XP_011744016.1; XM_011745714.1.
DR   AlphaFoldDB; A0A2K6BUV5; -.
DR   STRING; 9545.ENSMNEP00000015180; -.
DR   Ensembl; ENSMNET00000039388.1; ENSMNEP00000015180.1; ENSMNEG00000031722.1.
DR   GeneID; 105484239; -.
DR   KEGG; mni:105484239; -.
DR   CTD; 9573; -.
DR   GeneTree; ENSGT00940000162534; -.
DR   OMA; LDVAKDW; -.
DR   OrthoDB; 2912454at2759; -.
DR   Proteomes; UP000233120; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR   GO; GO:0001654; P:eye development; IEA:Ensembl.
DR   GO; GO:0030514; P:negative regulation of BMP signaling pathway; IEA:Ensembl.
DR   GO; GO:0045605; P:negative regulation of epidermal cell differentiation; IEA:Ensembl.
DR   GO; GO:0010453; P:regulation of cell fate commitment; IEA:Ensembl.
DR   GO; GO:0001501; P:skeletal system development; IEA:Ensembl.
DR   CDD; cd13764; TGF_beta_GDF1_3_like; 1.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR001839; TGF-b_C.
DR   InterPro; IPR015615; TGF-beta-rel.
DR   InterPro; IPR017948; TGFb_CS.
DR   PANTHER; PTHR11848:SF38; GROWTH/DIFFERENTIATION FACTOR 3; 1.
DR   PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR   Pfam; PF00019; TGF_beta; 1.
DR   PRINTS; PR00669; INHIBINA.
DR   SMART; SM00204; TGFB; 1.
DR   SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR   PROSITE; PS00250; TGF_BETA_1; 1.
DR   PROSITE; PS51362; TGF_BETA_2; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW   ECO:0000256|RuleBase:RU000354};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..364
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5014396720"
FT   DOMAIN          247..364
FT                   /note="TGF-beta family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS51362"
SQ   SEQUENCE   364 AA;  41323 MW;  54FE888C36BF9FA7 CRC64;
     MLRFLPDLAF SFLLTLAFGQ AVQFQEYVFL QFMGLDKAPS PQKFQPVPYI LKKIFQDREA
     AATTGVSRDL CYVKELGVRG NVLRFLPDQG FFLYPKKFSQ ASSCLQKLLY FNLSAIKERE
     QLTLAQLGLD LGPNSYYNLG PELELALFLV QEPHVWGQTT PKPGKMFVLR SVPWPQGAVH
     FNLLDVAKDW NDNSQKNFGL FLEILVKEDR DSGANFQPED TCARLRRSLH ASLLVVALNP
     DECPPSRKRR AAIPVPKVSC KNLCHRHQLF INFQDLGWHK WIIAPKGFMA NYCHGECPFS
     LTISLNSSNY AFMQALMHAV DPEIPQAVCV PTKLSPISML YQDNNDNVIL RHYEDMVVDE
     CGCG
//
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