ID A0A2K6BV60_MACNE Unreviewed; 1017 AA.
AC A0A2K6BV60;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=ALF transcription elongation factor 3 {ECO:0000313|Ensembl:ENSMNEP00000015303.1};
GN Name=AFF3 {ECO:0000313|Ensembl:ENSMNEP00000015303.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000015303.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000015303.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the AF4 family. {ECO:0000256|ARBA:ARBA00007354}.
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DR AlphaFoldDB; A0A2K6BV60; -.
DR STRING; 9545.ENSMNEP00000015303; -.
DR Ensembl; ENSMNET00000039511.1; ENSMNEP00000015303.1; ENSMNEG00000031770.1.
DR GeneTree; ENSGT00950000182974; -.
DR OMA; NSHRDCK; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000031770; Expressed in thymus and 7 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:Ensembl.
DR GO; GO:0003690; F:double-stranded DNA binding; IEA:Ensembl.
DR GO; GO:0035116; P:embryonic hindlimb morphogenesis; IEA:Ensembl.
DR GO; GO:0034612; P:response to tumor necrosis factor; IEA:Ensembl.
DR Gene3D; 6.10.250.2670; -; 1.
DR InterPro; IPR007797; AF4/FMR2.
DR InterPro; IPR043640; AF4/FMR2_CHD.
DR InterPro; IPR043639; AF4_int.
DR PANTHER; PTHR10528; AF4/FMR2 FAMILY MEMBER; 1.
DR PANTHER; PTHR10528:SF16; AF4_FMR2 FAMILY MEMBER 3; 1.
DR Pfam; PF05110; AF-4; 2.
DR Pfam; PF18875; AF4_int; 1.
DR Pfam; PF18876; AFF4_CHD; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120}.
FT DOMAIN 961..995
FT /note="AF4/FMR2 C-terminal homology"
FT /evidence="ECO:0000259|Pfam:PF18876"
FT REGION 23..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 143..164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 197..282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 323..498
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 519..727
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 782..855
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 878..961
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..40
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 41..56
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 208..229
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 248..264
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 384..449
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 519..535
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 632..663
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 664..678
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 687..707
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 810..839
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 840..855
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 895..919
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 930..955
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1017 AA; 110550 MW; 2EF2EEC70719748D CRC64;
MDSFDLALLQ EWDLESLCVY EPDRNALRRK ERERRNQETQ QDDGTFNSSY SLFSEPYKTN
KGDELSNRIQ NTLGNYDEMK DFLTDRSNQS HLVGVPKPGV PQTPVNKIDE HFVADSRAQT
QPSSIGSTTT STPAAVPVQQ TKRGTMGWQK AGHPPSDGQQ RATQQGSLRT LLGDGVGRQQ
PRAKQVCNVE VGLQTQERPP AMAAKHSSSG HCVQNFPPSL ASKPSLVQQK PTAYVRPMDG
QDQAPDESPK LKSPSETSVH CTSYRGVPAS KPEPARAKAK LSKFSIPKQV EESRSGETNS
CVEEIIREMT WLPPLSAIQA PGKVEPTKFP FPNKDSQLVS SGHNNPKKGD AEPESPDNGT
SNTSMLEDDL KLSSDEEENE QAAQRTALRT LSDSTVVQQP NCRTSVPSSK GSSSSSSSGS
SSSSSDSESS SGSDSETESS SSESEGSKPP HFSSPEAEPA SSNKWQLDKW LNKVNPHKPP
ILIQNESHGP ESNQYYNPVK EDVQDCGKVP DVCQPSLREK EVKSTCKEEQ RPRTANKAPG
NKGVKQKSPP AAVAVAVSAA APPPAVPCAP AENAPAPARR SAGKKPTRRA ERTSAGDGAN
LHRPEEPAAP DALGASVVVP PEPTKTRPCG NNRASHRKEL RSSVTCEKRR TRGLSRIVPK
SKEFIETESS SSSSSSDSDL ESEQEEYPLS KAQTVAASAS SGNDQRLKEA AANGGNGPRA
PVGSINARTT SDIAKELEEQ FYTLVPFGRN ELLSPLKDSD EVRSLWVKID LTLLSRIPEH
LPQEPGVLSA PATKDSESAL PSHTSDTPAE KALPKSKRKR KCDNEDDYRE IKKAQGEKDS
SSRLATSTGN TLSANHCNMN INSVAIPINK NEKMLRSPIS PLSDASKHKY TSEDLTSSSR
PNGNSLFTSA SSSKKPKADS QLQPHGGDLT KAAHNNSENI PLHKSRPQTE PWSPGSNGHR
DCKRQKLIFD DMPRSADYFM QEAKRMKHKA DAMVRPFSFQ IRSSKLRVYC IFITGTI
//
