ID A0A2K6BVE1_MACNE Unreviewed; 497 AA.
AC A0A2K6BVE1;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Centrosomal protein 57 {ECO:0000313|Ensembl:ENSMNEP00000015383.1};
GN Name=CEP57 {ECO:0000313|Ensembl:ENSMNEP00000015383.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000015383.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000015383.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000256|ARBA:ARBA00004300}.
CC -!- SIMILARITY: Belongs to the translokin family.
CC {ECO:0000256|ARBA:ARBA00008179}.
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DR AlphaFoldDB; A0A2K6BVE1; -.
DR Ensembl; ENSMNET00000039591.1; ENSMNEP00000015383.1; ENSMNEG00000031755.1.
DR GeneTree; ENSGT00530000063695; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000031755; Expressed in thymus and 12 other cell types or tissues.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0043015; F:gamma-tubulin binding; IEA:InterPro.
DR GO; GO:0042802; F:identical protein binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR Gene3D; 1.20.58.90; -; 1.
DR InterPro; IPR025913; Cep57_CLD.
DR InterPro; IPR024957; Cep57_MT-bd_dom.
DR PANTHER; PTHR19336:SF11; CENTROSOMAL PROTEIN OF 57 KDA; 1.
DR PANTHER; PTHR19336; UNCHARACTERIZED DUF1167; 1.
DR Pfam; PF14073; Cep57_CLD; 1.
DR Pfam; PF06657; Cep57_MT_bd; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120}.
FT DOMAIN 66..241
FT /note="Cep57 centrosome localisation"
FT /evidence="ECO:0000259|Pfam:PF14073"
FT DOMAIN 348..417
FT /note="Cep57 centrosome microtubule-binding"
FT /evidence="ECO:0000259|Pfam:PF06657"
FT REGION 1..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 244..273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 436..474
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 64..235
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..32
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 446..461
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 497 AA; 56653 MW; B45E6813C6106B27 CRC64;
LLGSSDSPAS ASRNILAEPS RSNGSMVRHS SSPYVVYPSD KPFLNSDLRR SPSKPTLAYP
ESNSRAIFSA LKNLQDKIRR LELERIQAEE SVKTLSRETI EYKKVLDEQI QERENSKNEE
SKHNQELTSQ LLAAENKCNL LEKQLEYMRN MIKHAEMERT SVLEKQVSLE RERQHDLTHV
QSQLEKLDLL EQEYNKLTTM QALAEKKMQE LEAKLHEEEQ ERKRMQAKAA ELQTGLETNR
LTFEDKATPR VPSARRIKKK KSKPPEKKSS RNYFGAQPHY RLCLGDMPFV AGKSTSPSHA
VVANVQLVLH LMKQHSKALC NDRVINSIPL AKQVSSRGGK SKKLSVTSPS NGINEELAEV
LQTLQDEFGQ MSFDHQQLAK LIQESPTVEL KDKLECELEA LVGRMEAKAN QITKVRKYQA
QLEKQKLEKQ KKELKATKKT LDEEGNSSSR SGITGTTNKK DFTKLRPGEK GRKNLQLLKD
MQTIQNSLQS SSLCWDY
//
