ID A0A2K6BZU7_MACNE Unreviewed; 456 AA.
AC A0A2K6BZU7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Zinc finger protein 25 {ECO:0008006|Google:ProtNLM};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000016925.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000016925.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000256|ARBA:ARBA00006991}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_011708528.1; XM_011710226.1.
DR RefSeq; XP_011708529.1; XM_011710227.1.
DR RefSeq; XP_011708530.1; XM_011710228.1.
DR AlphaFoldDB; A0A2K6BZU7; -.
DR STRING; 9545.ENSMNEP00000016925; -.
DR Ensembl; ENSMNET00000041147.1; ENSMNEP00000016925.1; ENSMNEG00000032480.1.
DR GeneID; 105463233; -.
DR KEGG; mni:105463233; -.
DR CTD; 219749; -.
DR GeneTree; ENSGT00940000159981; -.
DR OrthoDB; 3124525at2759; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000032480; Expressed in temporal lobe and 12 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 6.10.140.140; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 12.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR23226; ZINC FINGER AND SCAN DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR23226:SF346; ZINC FINGER PROTEIN 334; 1.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 12.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 12.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 7.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 11.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 8..79
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 118..145
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 146..173
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 174..201
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 202..229
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 230..257
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 258..285
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 286..313
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 314..341
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 342..369
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 370..397
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 398..425
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 426..453
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
SQ SEQUENCE 456 AA; 53652 MW; 936ABDD69884345A CRC64;
MNKFQGPVTL KDVIVEFTKE EWKLLTPAQR TLYKDVMLEN YSHLVSVGYH VNKPNAVFKL
KQGREPWILE VEYPHRGFPE DLWSIHDLEA RYRESQAGNS RNGELTKHQK TRTTEKAYEC
KECGKFFCQK SALIVHQHTH SKGKSYDCDK CGNSFSKNED LTRHQKIHTR DKTYECKECK
KIFYHLSSLS RHLRTHAGEK PYECNQCEKS SYQKPHLIEH QKTHTGEKPF ECTECGKFFY
VKAYLMVHQK THTGEKPYEC KECGKAFSQK SHLTVHQRTH TGEKPYKCKE CGKFFSRNSH
LKTHQRTHTG EKPYECKECR KCFYQKSALT VHQRTHTGEK PFECNKCGKT FYYKSDLTKH
QRKHTGEKPY ECTECGKSFS VNSVLRLHQR THTGEKPYSC KECGKSFSQK SHFIIHQRKH
TGEKPYECQE CGETFIQKSQ LTAHQKTHTK KRKAEK
//
