ID A0A2K6C044_MACNE Unreviewed; 985 AA.
AC A0A2K6C044;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Nucleotide-binding oligomerization domain-containing protein 2 {ECO:0000256|ARBA:ARBA00044203};
DE AltName: Full=Caspase recruitment domain-containing protein 15 {ECO:0000256|ARBA:ARBA00044293};
GN Name=NOD2 {ECO:0000313|Ensembl:ENSMNEP00000017042.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000017042.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000017042.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004187}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004193}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004193}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004124}. Membrane
CC {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004635}. Mitochondrion
CC {ECO:0000256|ARBA:ARBA00004173}.
CC -!- SIMILARITY: Belongs to the NOD1-NOD2 family.
CC {ECO:0000256|ARBA:ARBA00038296}.
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DR AlphaFoldDB; A0A2K6C044; -.
DR Ensembl; ENSMNET00000041266.1; ENSMNEP00000017042.1; ENSMNEG00000032525.1.
DR GeneTree; ENSGT00940000160934; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000032525; Expressed in bone marrow and 4 other cell types or tissues.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0097367; F:carbohydrate derivative binding; IEA:UniProt.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd08788; CARD_NOD2_2_CARD15; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR PANTHER; PTHR24106:SF64; NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF00619; CARD; 2.
DR Pfam; PF13516; LRR_6; 4.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR SMART; SM00368; LRR_RI; 6.
DR SUPFAM; SSF47986; DEATH domain; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50209; CARD; 2.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 3: Inferred from homology;
KW Adaptive immunity {ECO:0000256|ARBA:ARBA00023130};
KW Autophagy {ECO:0000256|ARBA:ARBA00023006};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 1..82
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT DOMAIN 107..191
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT DOMAIN 266..402
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
SQ SEQUENCE 985 AA; 109398 MW; B0E67CA3B6102224 CRC64;
MCSQEAFQAQ RSQLVELLVS GSLEGFESVL DWLLSWEVLS WEDYEGIHLL GQPLSHLARR
LLDTVWNKGT WACQKLVAAA QEAQADSQSP KLHGCWDPHS LHPAQDLQSH RPAIVRRLHS
HVEGVLDLAR ERGFVSQYEC DEIRLPIFTP SQRARRLLDL ATVKANGLAT FLLQHVQELP
VPLALPLEAA TCRKYMAKLR TTVSAQARFL STYDGAETLC LEDIYTENGL EVWADVGMAG
PPQKSPATLG LEELFSTRSH LNDDADTVLV VGEAGSGKST LLQRLHLLWA AGRDFQEFLF
VFPFSCRQLQ CVAKPLSVRT LLFEHCCWPD VDQEDIFQFL LDHPDRVLLT FDGFDEFKFR
FTDHERHCSP TDPTSVQTLL FNLLQGNLLK NARKVMTSRP AAVSAFLRKY IRTEFNLKGF
SEQGIELYLR KRHREPGVAD RLIRLLQATS ALHGLCHLPV FSWMVSKCHQ ELLLQEGVSP
KTTTDMYLLI LQHFLLHATS PDSASQGLGP SLLRGRLPTL LHLGRLALWG LGMCCYVFSA
QQLQAAQVSP DDISLGFLVR AKGVMPGSTA PLEFLHITFQ CFFAAFYLAF SADVSPALLR
HLFNCGRPGN SPMARLLPTL CIQGSEGKDG SVAALLQKAE PHNLQITAAF LAGLLSREHW
DLLAECQASE KALLRRQACA RWCLARSLRK HFHSIPPAAP GEAKSMHAMP GFIWLIRSLY
EMQEERLARK AARGLNVGHL KLTFCSVGPA ECAALAFVLR HLRQPVALQL DYNSVGDIGV
EQLLPCLGVC KALYLRDNNI SDRGICKLIE CALHCEQLQK LALGNNHITA AGARVLAEGL
RGNASLQFLG FWGNRVGDEG AQALAEALGD HQSLRWLSLV GNNIGSVGAQ ALALMLAKNV
MLEELCLEEN HLQDEGVCCL AEGLKRNSSL KILKLSNNCI TYLGAEALLQ ALERNDTILE
VWLRGNTFSL EEADKLGCRD TRLLL
//
