ID A0A2K6C1V1_MACNE Unreviewed; 848 AA.
AC A0A2K6C1V1;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE RecName: Full=B-cell receptor CD22 {ECO:0000256|ARBA:ARBA00040106};
DE AltName: Full=Sialic acid-binding Ig-like lectin 2 {ECO:0000256|ARBA:ARBA00041781};
GN Name=CD22 {ECO:0000313|Ensembl:ENSMNEP00000017654.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000017654.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000017654.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR RefSeq; XP_011763506.1; XM_011765204.1.
DR AlphaFoldDB; A0A2K6C1V1; -.
DR STRING; 9545.ENSMNEP00000017654; -.
DR Ensembl; ENSMNET00000041884.1; ENSMNEP00000017654.1; ENSMNEG00000032771.1.
DR GeneID; 105495532; -.
DR KEGG; mni:105495532; -.
DR CTD; 933; -.
DR GeneTree; ENSGT01010000222294; -.
DR OrthoDB; 4167621at2759; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000032771; Expressed in lymph node and 5 other cell types or tissues.
DR GO; GO:0005769; C:early endosome; IEA:Ensembl.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR GO; GO:0032809; C:neuronal cell body membrane; IEA:Ensembl.
DR GO; GO:0055037; C:recycling endosome; IEA:Ensembl.
DR GO; GO:0042609; F:CD4 receptor binding; IEA:Ensembl.
DR GO; GO:0019903; F:protein phosphatase binding; IEA:Ensembl.
DR GO; GO:0033691; F:sialic acid binding; IEA:Ensembl.
DR GO; GO:0042113; P:B cell activation; IEA:Ensembl.
DR GO; GO:0050859; P:negative regulation of B cell receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0050849; P:negative regulation of calcium-mediated signaling; IEA:Ensembl.
DR GO; GO:0002638; P:negative regulation of immunoglobulin production; IEA:Ensembl.
DR GO; GO:0030888; P:regulation of B cell proliferation; IEA:Ensembl.
DR GO; GO:0030100; P:regulation of endocytosis; IEA:Ensembl.
DR CDD; cd00096; Ig; 1.
DR CDD; cd20938; IgC1_CD22_d2; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 7.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR46958; B-CELL RECEPTOR CD22; 1.
DR PANTHER; PTHR46958:SF1; B-CELL RECEPTOR CD22; 1.
DR Pfam; PF08205; C2-set_2; 1.
DR Pfam; PF13895; Ig_2; 1.
DR Pfam; PF13927; Ig_3; 3.
DR SMART; SM00409; IG; 7.
DR SMART; SM00408; IGc2; 4.
DR SUPFAM; SSF48726; Immunoglobulin; 7.
DR PROSITE; PS50835; IG_LIKE; 6.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..848
FT /note="B-cell receptor CD22"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014341235"
FT TRANSMEM 689..707
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 144..236
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 243..325
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 332..417
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 420..501
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 506..583
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 594..677
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 848 AA; 95386 MW; E60AF38B5D1ECC60 CRC64;
MHLLGPWLLL LVLEYLAFSD SSKWNIEHPG TIYAWEGACV WVPCTYRVLD GALETFILFH
NPEYNQNMSK FEGTRLYEST KDGKVPSGQK RVQFLGNKIN NNCTLSIHPV HVNDSGQLGL
RMVSKTEKWM ERIHLNVSER PFPPRIQLPP KLQESQEVTL TCLLNFSCYG YQIQLQWLLE
GAPMRQAAVT LTSLSTKSVF TRSELKFSPQ WSHHGKIVTC ELHDVDGKVL SEDTVQLNVK
HTPKLTIEVT PNETIVRKGD SVTMTCKVNS SNPEYTTVSW LKDDILLKEQ NTLMLTLHEV
TKSQTGMYCC RVSNDVGPAT SEKVFLQVQY APEPSRVQIS QSPAVEGSEV NFLCISPANP
LPTNYTWYHN GKEVQGRTEK QFQIQKILPW HAGTYSCVAE NILGPGQRGP GAELDVQYPP
KTVTMVIENP TPIREGDTVT LSCNYSSSNP IVNHYEWRPR GTWEEPSLGV LKIQNIGWNN
TAVACAACNN WCSWASPVTL NVLYAPRGVR VRKIKPLSEI HSGNLVSLQC DFSSSHPKEV
QFFWEKNGSL LGKESQLNFD SISPEDAGSY SCWVNNSIGQ TASKAWTLEV LYAPRRLRVS
MSQGNQVMEG KTATLTCESD ANPPVYSYAW FDWNNQSLPY SGRMLRLEPV KVQHSGAYWC
QGTNRVGKGH SPLITLTVYY SPETIGRRVA VGLGSCLAIL ILAMCGFKVQ RRWKRTQSQQ
GLQENSSGQS FFVRNKKVRR TPLSEGPHSL GCYNPMMEDG ISYATLRFPE TNTPRTGDAE
TSELQGLPPD CDDTVTYSVL QKRQVGDYEN VIPDFPEDEG IHYSELIQFG FGERPQAQEN
VDYVIVKH
//