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Database: UniProt
Entry: A0A2K6C1V1_MACNE
LinkDB: A0A2K6C1V1_MACNE
Original site: A0A2K6C1V1_MACNE 
ID   A0A2K6C1V1_MACNE        Unreviewed;       848 AA.
AC   A0A2K6C1V1;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 31.
DE   RecName: Full=B-cell receptor CD22 {ECO:0000256|ARBA:ARBA00040106};
DE   AltName: Full=Sialic acid-binding Ig-like lectin 2 {ECO:0000256|ARBA:ARBA00041781};
GN   Name=CD22 {ECO:0000313|Ensembl:ENSMNEP00000017654.1};
OS   Macaca nemestrina (Pig-tailed macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000017654.1, ECO:0000313|Proteomes:UP000233120};
RN   [1] {ECO:0000313|Ensembl:ENSMNEP00000017654.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR   RefSeq; XP_011763506.1; XM_011765204.1.
DR   AlphaFoldDB; A0A2K6C1V1; -.
DR   STRING; 9545.ENSMNEP00000017654; -.
DR   Ensembl; ENSMNET00000041884.1; ENSMNEP00000017654.1; ENSMNEG00000032771.1.
DR   GeneID; 105495532; -.
DR   KEGG; mni:105495532; -.
DR   CTD; 933; -.
DR   GeneTree; ENSGT01010000222294; -.
DR   OrthoDB; 4167621at2759; -.
DR   Proteomes; UP000233120; Unplaced.
DR   Bgee; ENSMNEG00000032771; Expressed in lymph node and 5 other cell types or tissues.
DR   GO; GO:0005769; C:early endosome; IEA:Ensembl.
DR   GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR   GO; GO:0032809; C:neuronal cell body membrane; IEA:Ensembl.
DR   GO; GO:0055037; C:recycling endosome; IEA:Ensembl.
DR   GO; GO:0042609; F:CD4 receptor binding; IEA:Ensembl.
DR   GO; GO:0019903; F:protein phosphatase binding; IEA:Ensembl.
DR   GO; GO:0033691; F:sialic acid binding; IEA:Ensembl.
DR   GO; GO:0042113; P:B cell activation; IEA:Ensembl.
DR   GO; GO:0050859; P:negative regulation of B cell receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0050849; P:negative regulation of calcium-mediated signaling; IEA:Ensembl.
DR   GO; GO:0002638; P:negative regulation of immunoglobulin production; IEA:Ensembl.
DR   GO; GO:0030888; P:regulation of B cell proliferation; IEA:Ensembl.
DR   GO; GO:0030100; P:regulation of endocytosis; IEA:Ensembl.
DR   CDD; cd00096; Ig; 1.
DR   CDD; cd20938; IgC1_CD22_d2; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 7.
DR   InterPro; IPR013162; CD80_C2-set.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   PANTHER; PTHR46958; B-CELL RECEPTOR CD22; 1.
DR   PANTHER; PTHR46958:SF1; B-CELL RECEPTOR CD22; 1.
DR   Pfam; PF08205; C2-set_2; 1.
DR   Pfam; PF13895; Ig_2; 1.
DR   Pfam; PF13927; Ig_3; 3.
DR   SMART; SM00409; IG; 7.
DR   SMART; SM00408; IGc2; 4.
DR   SUPFAM; SSF48726; Immunoglobulin; 7.
DR   PROSITE; PS50835; IG_LIKE; 6.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..848
FT                   /note="B-cell receptor CD22"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5014341235"
FT   TRANSMEM        689..707
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          144..236
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          243..325
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          332..417
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          420..501
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          506..583
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          594..677
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
SQ   SEQUENCE   848 AA;  95386 MW;  E60AF38B5D1ECC60 CRC64;
     MHLLGPWLLL LVLEYLAFSD SSKWNIEHPG TIYAWEGACV WVPCTYRVLD GALETFILFH
     NPEYNQNMSK FEGTRLYEST KDGKVPSGQK RVQFLGNKIN NNCTLSIHPV HVNDSGQLGL
     RMVSKTEKWM ERIHLNVSER PFPPRIQLPP KLQESQEVTL TCLLNFSCYG YQIQLQWLLE
     GAPMRQAAVT LTSLSTKSVF TRSELKFSPQ WSHHGKIVTC ELHDVDGKVL SEDTVQLNVK
     HTPKLTIEVT PNETIVRKGD SVTMTCKVNS SNPEYTTVSW LKDDILLKEQ NTLMLTLHEV
     TKSQTGMYCC RVSNDVGPAT SEKVFLQVQY APEPSRVQIS QSPAVEGSEV NFLCISPANP
     LPTNYTWYHN GKEVQGRTEK QFQIQKILPW HAGTYSCVAE NILGPGQRGP GAELDVQYPP
     KTVTMVIENP TPIREGDTVT LSCNYSSSNP IVNHYEWRPR GTWEEPSLGV LKIQNIGWNN
     TAVACAACNN WCSWASPVTL NVLYAPRGVR VRKIKPLSEI HSGNLVSLQC DFSSSHPKEV
     QFFWEKNGSL LGKESQLNFD SISPEDAGSY SCWVNNSIGQ TASKAWTLEV LYAPRRLRVS
     MSQGNQVMEG KTATLTCESD ANPPVYSYAW FDWNNQSLPY SGRMLRLEPV KVQHSGAYWC
     QGTNRVGKGH SPLITLTVYY SPETIGRRVA VGLGSCLAIL ILAMCGFKVQ RRWKRTQSQQ
     GLQENSSGQS FFVRNKKVRR TPLSEGPHSL GCYNPMMEDG ISYATLRFPE TNTPRTGDAE
     TSELQGLPPD CDDTVTYSVL QKRQVGDYEN VIPDFPEDEG IHYSELIQFG FGERPQAQEN
     VDYVIVKH
//
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