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Database: UniProt
Entry: A0A2K6C3F0_MACNE
LinkDB: A0A2K6C3F0_MACNE
Original site: A0A2K6C3F0_MACNE 
ID   A0A2K6C3F0_MACNE        Unreviewed;       530 AA.
AC   A0A2K6C3F0;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 34.
DE   RecName: Full=Estrogen receptor beta {ECO:0000256|ARBA:ARBA00014904};
DE   AltName: Full=Nuclear receptor subfamily 3 group A member 2 {ECO:0000256|ARBA:ARBA00032420};
GN   Name=ESR2 {ECO:0000313|Ensembl:ENSMNEP00000018179.1};
OS   Macaca nemestrina (Pig-tailed macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000018179.1, ECO:0000313|Proteomes:UP000233120};
RN   [1] {ECO:0000313|Ensembl:ENSMNEP00000018179.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PIRNR:PIRNR002527}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR3
CC       subfamily. {ECO:0000256|ARBA:ARBA00005413,
CC       ECO:0000256|PIRNR:PIRNR002527}.
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DR   RefSeq; XP_011725913.1; XM_011727611.1.
DR   RefSeq; XP_011725914.1; XM_011727612.1.
DR   RefSeq; XP_011725916.1; XM_011727614.1.
DR   AlphaFoldDB; A0A2K6C3F0; -.
DR   STRING; 9545.ENSMNEP00000018179; -.
DR   Ensembl; ENSMNET00000042414.1; ENSMNEP00000018179.1; ENSMNEG00000033018.1.
DR   GeneID; 105473690; -.
DR   KEGG; mni:105473690; -.
DR   CTD; 2100; -.
DR   GeneTree; ENSGT00940000156116; -.
DR   OMA; RHRNSED; -.
DR   OrthoDB; 5387678at2759; -.
DR   Proteomes; UP000233120; Unplaced.
DR   Bgee; ENSMNEG00000033018; Expressed in spleen and 8 other cell types or tissues.
DR   GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
DR   GO; GO:0034056; F:estrogen response element binding; IEA:Ensembl.
DR   GO; GO:0030284; F:nuclear estrogen receptor activity; IEA:Ensembl.
DR   GO; GO:0004879; F:nuclear receptor activity; IEA:Ensembl.
DR   GO; GO:0005496; F:steroid binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0071392; P:cellular response to estradiol stimulus; IEA:InterPro.
DR   GO; GO:0030520; P:intracellular estrogen receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:Ensembl.
DR   CDD; cd07171; NR_DBD_ER; 1.
DR   CDD; cd06949; NR_LBD_ER; 1.
DR   Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR   Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR   InterPro; IPR021064; ER-beta-like_N.
DR   InterPro; IPR028355; ER-beta/gamma.
DR   InterPro; IPR024178; Est_rcpt/est-rel_rcp.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   PANTHER; PTHR48092:SF12; ESTROGEN RECEPTOR BETA; 1.
DR   PANTHER; PTHR48092; KNIRPS-RELATED PROTEIN-RELATED; 1.
DR   Pfam; PF12497; ERbeta_N; 1.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PIRSF; PIRSF500102; ER-b; 1.
DR   PIRSF; PIRSF002527; ER-like_NR; 1.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR   SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW   Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR002527};
KW   Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PIRNR:PIRNR002527};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163,
KW   ECO:0000256|PIRNR:PIRNR002527};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW   ECO:0000256|PIRNR:PIRNR002527};
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          146..221
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000259|PROSITE:PS51030"
FT   DOMAIN          264..498
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000259|PROSITE:PS51843"
FT   REGION          509..530
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   530 AA;  59200 MW;  2E55D81A6D19DC48 CRC64;
     MDIKNSPSSL NSPSSYNCSQ SILPLEHGSI YIPSSYVESH HEYPAMTFYS PAVMNYSIPS
     NVTNLEGGPG RQTASPNVLW PTPGHLSPLA VHRQLSHLYA EPQKSPWCEA RSLEHTLPVN
     RETLKRKVSG NRCTSPVTSP SSKRDAHFCA VCSDFASGYH YGVWSCEGCK AFFKRSIQGH
     NDYICPATNQ CTIDKNRRKS CQACRLRKCY EVGMVKCGSR RERCGYRLVR RQRSADEQLH
     CASKAKRSGS HAPLVRELLL DALSPEQLVL TLLEAEPPHV LISRPSAPFT EASMMMSLTK
     LADKELVHMI SWAKKIPGFV ELSLFDQVRL LESCWMEVLM VGLMWRSIDH PGKLIFAPDL
     VLDRDEGKCV EGILEIFDML LATTSRFREL KLQHKEYLCV KAMILLNSNM YPLVTATQDA
     DSSRKLAHLL NAVTDALVWV IAKSGISSQQ QSMRLANLLM LLSHVRHASN KGMEHLLSMK
     CKNVVPVYDL LLEMLNAHVL RGCKSSITGS ACSPAEDSKN KEGSQNPQSQ
//
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