ID A0A2K6C414_MACNE Unreviewed; 509 AA.
AC A0A2K6C414;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE RecName: Full=Heat shock 70 kDa protein 14 {ECO:0000256|ARBA:ARBA00018766};
GN Name=HSPA14 {ECO:0000313|Ensembl:ENSMNEP00000018407.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000018407.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000018407.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Component of the ribosome-associated complex (RAC), a complex
CC involved in folding or maintaining nascent polypeptides in a folding-
CC competent state. In the RAC complex, binds to the nascent polypeptide
CC chain, while DNAJC2 stimulates its ATPase activity.
CC {ECO:0000256|ARBA:ARBA00024825}.
CC -!- SUBUNIT: Component of ribosome-associated complex (RAC), a heterodimer
CC composed of Hsp70/DnaK-type chaperone HSPA14 and Hsp40/DnaJ-type
CC chaperone DNAJC2. {ECO:0000256|ARBA:ARBA00011347}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}.
CC -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC {ECO:0000256|ARBA:ARBA00007381, ECO:0000256|RuleBase:RU003322}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_011754790.1; XM_011756488.1.
DR AlphaFoldDB; A0A2K6C414; -.
DR SMR; A0A2K6C414; -.
DR STRING; 9545.ENSMNEP00000018407; -.
DR Ensembl; ENSMNET00000042642.1; ENSMNEP00000018407.1; ENSMNEG00000033128.1.
DR GeneID; 105490645; -.
DR KEGG; mni:105490645; -.
DR CTD; 51182; -.
DR GeneTree; ENSGT00940000156380; -.
DR OMA; GSTCACA; -.
DR OrthoDB; 3125219at2759; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000033128; Expressed in thymus and 12 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005840; C:ribosome; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR CDD; cd10238; HSPA14-like_NBD; 1.
DR Gene3D; 3.30.30.30; -; 1.
DR Gene3D; 3.30.420.40; -; 2.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR018181; Heat_shock_70_CS.
DR InterPro; IPR029047; HSP70_peptide-bd_sf.
DR InterPro; IPR013126; Hsp_70_fam.
DR InterPro; IPR042049; HSPA14_NBD.
DR PANTHER; PTHR19375:SF438; HEAT SHOCK 70 KDA PROTEIN 14; 1.
DR PANTHER; PTHR19375; HEAT SHOCK PROTEIN 70KDA; 1.
DR Pfam; PF00012; HSP70; 1.
DR PRINTS; PR00301; HEATSHOCK70.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR SUPFAM; SSF100920; Heat shock protein 70kD (HSP70), peptide-binding domain; 1.
DR PROSITE; PS01036; HSP70_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU003322};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003322};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120}.
SQ SEQUENCE 509 AA; 54882 MW; C0ECE7A36859AEC7 CRC64;
MAAIGVHLGC TSACVAVYKD GRAGVVANDA GDRVTPAVVA YSENEEIVGL AAKQSRIRNI
SNTVMKVKQI LGRSSNDPQA QKYITESKCL VIEKNGKLRY EIDTGEETRF VNPEDVVRLI
FSKMKETAHS VLGSDANDVV ITVPFDFGEK QKNALGEAAR AAGFNVLRLI HEPSAALLAY
GIGQDSPNGK SNILVFKLGG TSLSLSVMEV NSGIYRVLST NTDDNIGGAH FTETLAQYLA
SEFQRSFKHD VKGNARAMMK LMNSAEVAKH SLSTLGSANC FLDSLYEGQD FDCNVSRARF
ELLCSPLFNK CIEAIRGLLD QSGFTADDIN KVVLCGGSSR IPKLQQLIKD LFPAVELLNS
IPPDEVIPIG AAIEAGILIG KENLLVEDSL MIECSARDIL VKGVDESGAS RFTVLFPSGT
PLPARRQHTL QAPGSISSVC LELYESDGKN SAKEETKFAQ VVLQDLDKKE NGLRDILAVL
TMKRDGSLHV TCTDQETGKC EAISIEVAS
//