ID   A0A2K6C4K8_MACNE        Unreviewed;       749 AA.
AC   A0A2K6C4K8;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   SubName: Full=Discs large MAGUK scaffold protein 2 {ECO:0000313|Ensembl:ENSMNEP00000018597.1};
GN   Name=DLG2 {ECO:0000313|Ensembl:ENSMNEP00000018597.1};
OS   Macaca nemestrina (Pig-tailed macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000018597.1, ECO:0000313|Proteomes:UP000233120};
RN   [1] {ECO:0000313|Ensembl:ENSMNEP00000018597.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A2K6C4K8; -.
DR   Ensembl; ENSMNET00000042833.1; ENSMNEP00000018597.1; ENSMNEG00000032861.1.
DR   GeneTree; ENSGT00940000155156; -.
DR   Proteomes; UP000233120; Unplaced.
DR   Bgee; ENSMNEG00000032861; Expressed in temporal lobe and 9 other cell types or tissues.
DR   GO; GO:0031594; C:neuromuscular junction; IEA:InterPro.
DR   GO; GO:0043005; C:neuron projection; IEA:InterPro.
DR   GO; GO:0019900; F:kinase binding; IEA:InterPro.
DR   GO; GO:0007268; P:chemical synaptic transmission; IEA:InterPro.
DR   CDD; cd00071; GMPK; 1.
DR   CDD; cd00992; PDZ_signaling; 3.
DR   CDD; cd12032; SH3_DLG2; 1.
DR   Gene3D; 2.30.42.10; -; 3.
DR   Gene3D; 3.30.63.10; Guanylate Kinase phosphate binding domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR019583; DLG1-4_PDZ_assoc.
DR   InterPro; IPR016313; DLG1-like.
DR   InterPro; IPR035759; DLG2_SH3.
DR   InterPro; IPR008145; GK/Ca_channel_bsu.
DR   InterPro; IPR008144; Guanylate_kin-like_dom.
DR   InterPro; IPR020590; Guanylate_kinase_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR23119; DISCS LARGE; 1.
DR   PANTHER; PTHR23119:SF6; DISKS LARGE HOMOLOG 2; 1.
DR   Pfam; PF00625; Guanylate_kin; 1.
DR   Pfam; PF00595; PDZ; 3.
DR   Pfam; PF10600; PDZ_assoc; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   PIRSF; PIRSF001741; MAGUK_DLGH; 1.
DR   SMART; SM00072; GuKc; 1.
DR   SMART; SM00228; PDZ; 3.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF50156; PDZ domain-like; 3.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR   PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR   PROSITE; PS50106; PDZ; 3.
DR   PROSITE; PS50002; SH3; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          47..134
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          142..229
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          318..399
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          433..503
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          559..734
FT                   /note="Guanylate kinase-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50052"
SQ   SEQUENCE   749 AA;  83389 MW;  196C179CC4BEEEFE CRC64;
     MQRPSASRAE NYQLLWDTIA SLKQCEQAMQ HAFIPVNGTE IEYEFEEITL ERGNSGLGFS
     IAGGTDNPHI GDDPGIFITK IIPGGAAAED GRLRVNDCIL RVNEVDVSEV SHSKAVEALK
     EAGSIVRLYV RRRRPILETV VEIKLFKGPK GLGFSIAGGV GNQHIPGDNS IYVTKIIDGG
     AAQKDGRLQV GDRLLMVNNY SLEEVTHEEA VAILKNTSEV VYLKVGKPTT IYMTDPYGPP
     DITHSYSPPM ENHLLSGNNG TLEYKTSLPP ISPGRYSPIP KHMLVDDDYT SHSQHSTTTR
     QPSVTLQRAI SLEGEPRKVV LHKGSTGLGF NIVGGEDGEG IFVSFILAGG PADLSGELQR
     GDQILSVNGI DLRGASHEQA AAALKGAGQT VTIIAQYQPE DYARFEAKIH DLREQMMNHS
     MSSGSGSLRT NQKRSLYVRA MFDYDKSKDS GLPSQGLSFK YGDILHVINA SDDEWWQARR
     VMLEGDSEEM GVIPSKRRVE RKERARLKTV KFNAKPGVID SKGDIPGLGD DGYGTKTLRG
     QEDLILSYEP VTRQEINYTR PVIILGPMKD RINDDLISEF PDKFGSCVPH TTRPKRDYEV
     DGRDYHFVIS REQMEKDIQE HKFIEAGQYN DNLYGTSVQS VRFVAERGKH CILDVSGNAI
     KRLQVAQLYP IAIFIKPRSL EPLMEMNKRL TEEQAKKTYD RAIKLEQEFG EYFTAIVQGD
     TLEDIYNQCK LVIEEQSGPF IWIPSKEKL
//