ID A0A2K6C5A2_MACNE Unreviewed; 361 AA.
AC A0A2K6C5A2;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=AlkB homolog 1, histone H2A dioxygenase {ECO:0000313|Ensembl:ENSMNEP00000018840.1};
GN Name=ALKBH1 {ECO:0000313|Ensembl:ENSMNEP00000018840.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000018840.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000018840.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|PIRSR:PIRSR604574-2};
CC Note=Binds 1 Fe(2+) ion per subunit. {ECO:0000256|PIRSR:PIRSR604574-2};
CC -!- SIMILARITY: Belongs to the alkB family.
CC {ECO:0000256|ARBA:ARBA00007879}.
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DR AlphaFoldDB; A0A2K6C5A2; -.
DR SMR; A0A2K6C5A2; -.
DR STRING; 9545.ENSMNEP00000018840; -.
DR Ensembl; ENSMNET00000043077.1; ENSMNEP00000018840.1; ENSMNEG00000033314.1.
DR GeneTree; ENSGT00390000004599; -.
DR OMA; YKRRDPP; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000033314; Expressed in skeletal muscle tissue and 12 other cell types or tissues.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0000791; C:euchromatin; IEA:Ensembl.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0042056; F:chemoattractant activity; IEA:Ensembl.
DR GO; GO:0140078; F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity; IEA:Ensembl.
DR GO; GO:0008198; F:ferrous iron binding; IEA:Ensembl.
DR GO; GO:0070579; F:methylcytosine dioxygenase activity; IEA:Ensembl.
DR GO; GO:0035516; F:oxidative DNA demethylase activity; IEA:Ensembl.
DR GO; GO:0000049; F:tRNA binding; IEA:Ensembl.
DR GO; GO:1990984; F:tRNA demethylase activity; IEA:Ensembl.
DR GO; GO:0048589; P:developmental growth; IEA:Ensembl.
DR GO; GO:0006307; P:DNA dealkylation involved in DNA repair; IEA:Ensembl.
DR GO; GO:0080111; P:DNA demethylation; IEA:Ensembl.
DR GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
DR GO; GO:0001764; P:neuron migration; IEA:Ensembl.
DR GO; GO:0031175; P:neuron projection development; IEA:Ensembl.
DR GO; GO:0001890; P:placenta development; IEA:Ensembl.
DR GO; GO:0070129; P:regulation of mitochondrial translation; IEA:Ensembl.
DR GO; GO:0006448; P:regulation of translational elongation; IEA:Ensembl.
DR GO; GO:0006446; P:regulation of translational initiation; IEA:Ensembl.
DR GO; GO:0042245; P:RNA repair; IEA:Ensembl.
DR GO; GO:1990983; P:tRNA demethylation; IEA:Ensembl.
DR GO; GO:0002101; P:tRNA wobble cytosine modification; IEA:Ensembl.
DR Gene3D; 2.60.120.590; Alpha-ketoglutarate-dependent dioxygenase AlkB-like; 1.
DR InterPro; IPR004574; Alkb.
DR InterPro; IPR027450; AlkB-like.
DR InterPro; IPR037151; AlkB-like_sf.
DR InterPro; IPR005123; Oxoglu/Fe-dep_dioxygenase.
DR PANTHER; PTHR16557; ALKYLATED DNA REPAIR PROTEIN ALKB-RELATED; 1.
DR PANTHER; PTHR16557:SF2; NUCLEIC ACID DIOXYGENASE ALKBH1; 1.
DR Pfam; PF13532; 2OG-FeII_Oxy_2; 1.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR PROSITE; PS51471; FE2OG_OXY; 1.
PE 3: Inferred from homology;
KW Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Iron {ECO:0000256|PIRSR:PIRSR604574-2};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR604574-2};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120}.
FT DOMAIN 185..319
FT /note="Fe2OG dioxygenase"
FT /evidence="ECO:0000259|PROSITE:PS51471"
FT BINDING 203
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR604574-2"
FT BINDING 205
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR604574-2"
FT BINDING 259
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR604574-2"
SQ SEQUENCE 361 AA; 40849 MW; B708B4A11E268022 CRC64;
MGKMAAVVGS VATLATEPGE DAFRKLFRFY RQSRPGTADL EGVIDFSAAH EARGTGPGAQ
KVVKSQLNVS SVSEHNAYRA GLQPVSKWQA YGLKGYPGFI FIPNPFLPGY QWHWVKQCLK
LYSQKPNVCN LDKHMTKEET QDLWEQSKEF LRYKEVTKRR PRSLLEKLRW VTLGYHYNWD
SKGFRAEAGI LNYYRLDSTL GIHVDRSELD HSKPLLSFSF GQSAIFLLGG LQRDEAPTAM
FMHSGDIMIM SGFSRLLNHA VPRVLPNPDG EGLPHCLEAP LPAVLPRDSM IEPCSMEDWQ
VCASYLKTAR VNMTVRQVLA TDQNFPLEPI EDKKRDISTE GFCHLDDQNS QVKRARINPD
S
//
