ID A0A2K6C5E1_MACNE Unreviewed; 1565 AA.
AC A0A2K6C5E1;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE SubName: Full=Synemin {ECO:0000313|Ensembl:ENSMNEP00000018873.1};
GN Name=SYNM {ECO:0000313|Ensembl:ENSMNEP00000018873.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000018873.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000018873.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR RefSeq; XP_011735636.1; XM_011737334.1.
DR STRING; 9545.ENSMNEP00000018873; -.
DR Ensembl; ENSMNET00000043111.1; ENSMNEP00000018873.1; ENSMNEG00000033330.1.
DR GeneID; 105479403; -.
DR KEGG; mni:105479403; -.
DR CTD; 23336; -.
DR GeneTree; ENSGT00940000159268; -.
DR OMA; KMLYASE; -.
DR OrthoDB; 5353519at2759; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000033330; Expressed in skeletal muscle tissue and 12 other cell types or tissues.
DR GO; GO:0043034; C:costamere; IEA:Ensembl.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:Ensembl.
DR GO; GO:0008307; F:structural constituent of muscle; IEA:Ensembl.
DR GO; GO:0017166; F:vinculin binding; IEA:Ensembl.
DR GO; GO:0045104; P:intermediate filament cytoskeleton organization; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR030634; SYNM.
DR PANTHER; PTHR47136; SYNEMIN; 1.
DR PANTHER; PTHR47136:SF1; SYNEMIN; 1.
DR Pfam; PF00038; Filament; 1.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120}.
FT DOMAIN 11..322
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 403..424
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 463..610
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 820..842
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1019..1060
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1078..1107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1193..1220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1371..1400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1476..1497
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 15..49
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 78..140
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 192..268
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 463..481
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 492..589
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1019..1036
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1093..1107
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1371..1396
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1476..1494
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1565 AA; 172624 MW; 5C203A560FEB5820 CRC64;
MLSWRLQTGP EKAELQELNA RLYDYVCRVR ELERENLLLE EELRGRRGRE GLWAEGQARC
AEEARSLRQQ LDELSWATAL AEGERDALRR ELRELQRLDA EERAARGRLD AELGAQQREL
QEALGTRAAL EALLGRLQAE RRGLDAAHER DVRELRTRAA NLTMHFRARA TGPAAPPPRL
REVHDSYALL VAESWRETVQ LYEDEVRELE EALRRGEESR LQAEEETRLC AQEAEGLQRE
VLGLEQLRAR LEEELLRMRE EYGLQAQERQ RVIDCLEDEK ATLTLAMADW LRDYQDLLQV
KTGLSLEVAT YRALLEGESN PEIVVWTEHI ENMPSEFRNK SYHYTDSLLQ RENERNLFSR
QKAPLASLNH SSALYSNLSA HRGYQTGTSV GGDARGGFLG SGYSSSATTQ QENSYGKTVN
SSTNVRTFSP TYGLLRNTEA QVKTFPDRPK AGDTREVPVY RAEDSTVARE SYRDRRDNVA
AGASESTRSN ERTVILGKKT EVKATREQEG NRPETIRTKP EEKMFDSKEK ASEERNLRWE
ELTKLDKEAR QRESQQMREK AKEKDSPKEK SGQEREIPIS LEVSQDRRAE VSPKGLQMPV
KDAGGGTGRE AEARALRSTL GTRDAAGSLQ GDSMTETVAE NIVTSILKQF TQSPETEASA
DSFPDTKVTY VDRKELPGER KTKTEIVVES KLTEDVDISD EAGLDYLLSK DIKEVGLKGR
SAEQMIGDVI NLGLKGREGR AKVVNVEIVE EPVSYVSEGK PEEFSVPFKV EEVEDVSPGS
WGLVKEEEGY GESDVTFSVN QHQRTKQPQE NTTHVEEVTE AGDSESEQSY FVSTPDEYPG
GHDRDDGSVY GQIHIEEEST IRYSWQDEIV QGTGRRTQKD GAVGEKVVKP SEIPASSLEG
DLGSTHWKEQ ARSGEFHAEP TVIEKEIKIP HEFHTSMKGI SSKEPRQQLV EVIGQLEETL
PERMREELSA LTREGQGGPG SISVDVKKVQ GAGGGSVTLV AEVNVSQTVD ADRLDLEELS
RDEASEMEKA VESVVRESLS KQRSPAPGSP DEEDGAEAPA AGARFRRWAT RELYIPAGES
EDAGGAPHSS GQHARQGPVS ATVEVSSPTG FAQSQVLEDV NQAARHIKLG PSEVWRTERM
SYEGPAAEVV EVSGGGDLSQ AASPTGASRS VRHVTLGPGP SPPSREVIFL GPAPACPEAG
GSPEPGPAES SADTDGLGRH STFGSRQFHA EKEIIFQGPI SAAGKVGDYF TKEESVGTQT
SVRQLQLGPK EGFSGQIQFT APLSDEVEVG VRGDSVHMEG LPGSSTSIRH ISIGPQRHQT
TQQIVYHGLV PQSGESGDSE SIVHGEGSAD VHQATHSHTL GRQTIMTEKS TFQSVVSESP
QEDSAGDTSG AEMTSGVSRS FRHIRLGPTE TETSEHVVVH GPVSRTFVLA GSADSPELGK
LADSRRTLRH ITPGPKETSF TFQMDVSNVE AIRSRTQEAG DRGVSDHGAW TDADSRNDRA
VGMSFKASAG EGDQAHGEQG KEQAMFDKKV QLQRMVDQRS VISDEKKVAL LYLDNEEEEN
DGHWF
//
