ID A0A2K6C5F4_MACNE Unreviewed; 492 AA.
AC A0A2K6C5F4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Dynein axonemal heavy chain 5 {ECO:0000313|Ensembl:ENSMNEP00000018883.1};
GN Name=DNAH5 {ECO:0000313|Ensembl:ENSMNEP00000018883.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000018883.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000018883.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR AlphaFoldDB; A0A2K6C5F4; -.
DR Ensembl; ENSMNET00000043121.1; ENSMNEP00000018883.1; ENSMNEG00000033291.1.
DR GeneTree; ENSGT00940000155533; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000033291; Expressed in pituitary gland and 1 other cell type or tissue.
DR GO; GO:0030286; C:dynein complex; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.20.920.20; -; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46532:SF13; DYNEIN CYTOPLASMIC 1 HEAVY CHAIN 1; 1.
DR PANTHER; PTHR46532; MALE FERTILITY FACTOR KL5; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF12777; MT; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120}.
FT DOMAIN 2..64
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 176..355
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 385..483
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT COILED 85..122
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 247..295
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 492 AA; 55892 MW; E11152A1D1A23111 CRC64;
MRVSEHFLAS YDIDCSWEIK KEVVQCMGSF QDGVAEKCAD YFQRFRRSTH VTPKSYLSFI
QGYKLIYGEK HMEVQTLANR MNTGLEKLKE ASESVAALSK ELEVKEKELQ VANNKADTVL
KEVTMKAQAA EKVRAEVQKV KDRAQAIVDS ISKDKAIAEE KLEAAKPALE EAEAALQQFP
KDTINEEVIE FLSPYFEMPD YNIETAKRVC GNVAGLCSWT KAMASFFSIN REVLPLKANL
VVQENRHLLA MQDLQKAQAE LDDKQAELDV VQAEYEQAMT EKQTLLEDAE RCRHKMQTAS
TLISGLAGEK ERWTQQSQEF AAQTKRLVGD VLLATAFLSY SGPFNQEFRD LLLNDWRKEM
KARKIPFGKN LNLNEMLIDA PTISEWNLQG LPNDDLSIQN GIIVTKASRY PLLIDPQTQG
KIWIKNKESR NEFQITSLNH KYFRNHLEDS LSLGRPLLIE DVGEELDPAL DNVLERNFIK
TGSTFKVGYT SG
//
