ID   A0A2K6C5G0_MACNE        Unreviewed;      1253 AA.
AC   A0A2K6C5G0;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   SubName: Full=Synemin {ECO:0000313|Ensembl:ENSMNEP00000018879.1};
GN   Name=SYNM {ECO:0000313|Ensembl:ENSMNEP00000018879.1};
OS   Macaca nemestrina (Pig-tailed macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000018879.1, ECO:0000313|Proteomes:UP000233120};
RN   [1] {ECO:0000313|Ensembl:ENSMNEP00000018879.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000256|RuleBase:RU000685}.
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DR   RefSeq; XP_011735637.1; XM_011737335.1.
DR   AlphaFoldDB; A0A2K6C5G0; -.
DR   Ensembl; ENSMNET00000043117.1; ENSMNEP00000018879.1; ENSMNEG00000033330.1.
DR   GeneID; 105479403; -.
DR   CTD; 23336; -.
DR   GeneTree; ENSGT00940000159268; -.
DR   OrthoDB; 5353519at2759; -.
DR   Proteomes; UP000233120; Unplaced.
DR   Bgee; ENSMNEG00000033330; Expressed in skeletal muscle tissue and 12 other cell types or tissues.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR   GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:InterPro.
DR   GO; GO:0008307; F:structural constituent of muscle; IEA:InterPro.
DR   GO; GO:0045104; P:intermediate filament cytoskeleton organization; IEA:InterPro.
DR   Gene3D; 1.20.5.170; -; 1.
DR   Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR   InterPro; IPR018039; IF_conserved.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR030634; SYNM.
DR   PANTHER; PTHR47136; SYNEMIN; 1.
DR   PANTHER; PTHR47136:SF1; SYNEMIN; 1.
DR   Pfam; PF00038; Filament; 1.
DR   SMART; SM01391; Filament; 1.
DR   SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR   PROSITE; PS00226; IF_ROD_1; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW   ECO:0000256|RuleBase:RU000685};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233120}.
FT   DOMAIN          11..322
FT                   /note="IF rod"
FT                   /evidence="ECO:0000259|PROSITE:PS51842"
FT   REGION          403..424
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          463..630
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          820..842
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1019..1060
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1078..1107
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1164..1185
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          15..49
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          78..140
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          192..268
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        463..481
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        492..589
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1019..1036
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1093..1107
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1164..1182
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1253 AA;  140008 MW;  FAB72DFB8BCE8F3E CRC64;
     MLSWRLQTGP EKAELQELNA RLYDYVCRVR ELERENLLLE EELRGRRGRE GLWAEGQARC
     AEEARSLRQQ LDELSWATAL AEGERDALRR ELRELQRLDA EERAARGRLD AELGAQQREL
     QEALGTRAAL EALLGRLQAE RRGLDAAHER DVRELRTRAA NLTMHFRARA TGPAAPPPRL
     REVHDSYALL VAESWRETVQ LYEDEVRELE EALRRGEESR LQAEEETRLC AQEAEGLQRE
     VLGLEQLRAR LEEELLRMRE EYGLQAQERQ RVIDCLEDEK ATLTLAMADW LRDYQDLLQV
     KTGLSLEVAT YRALLEGESN PEIVVWTEHI ENMPSEFRNK SYHYTDSLLQ RENERNLFSR
     QKAPLASLNH SSALYSNLSA HRGYQTGTSV GGDARGGFLG SGYSSSATTQ QENSYGKTVN
     SSTNVRTFSP TYGLLRNTEA QVKTFPDRPK AGDTREVPVY RAEDSTVARE SYRDRRDNVA
     AGASESTRSN ERTVILGKKT EVKATREQEG NRPETIRTKP EEKMFDSKEK ASEERNLRWE
     ELTKLDKEAR QRESQQMREK AKEKDSPKEK SGQEREIPIS LEVSQDRRAE VSPKGLQMPV
     KDAGGGTGRE AEARALRSTL GTRDAAGSLQ GDSMTETVAE NIVTSILKQF TQSPETEASA
     DSFPDTKVTY VDRKELPGER KTKTEIVVES KLTEDVDISD EAGLDYLLSK DIKEVGLKGR
     SAEQMIGDVI NLGLKGREGR AKVVNVEIVE EPVSYVSEGK PEEFSVPFKV EEVEDVSPGS
     WGLVKEEEGY GESDVTFSVN QHQRTKQPQE NTTHVEEVTE AGDSESEQSY FVSTPDEYPG
     GHDRDDGSVY GQIHIEEEST IRYSWQDEIV QGTGRRTQKD GAVGEKVVKP SEIPASSLEG
     DLGSTHWKEQ ARSGEFHAEP TVIEKEIKIP HEFHTSMKGI SSKEPRQQLV EVIGQLEETL
     PERMREELSA LTREGQGGPG SISVDVKKVQ GAGGGSVTLV AEVNVSQTVD ADRLDLEELS
     RDEASEMEKA VESVVRESLS KQRSPAPGSP DEEDGAEAPA AGARFRRWAT RELYIPAGES
     EDAGGAPHSS GQHARQGPVS ATVEVSSPTG FAQSQVLEDV NQAARHIKLG PSEVWRTERM
     SYEGPAAEVV EMDVSNVEAI RSRTQEAGDR GVSDHGAWTD ADSRNDRAVG MSFKASAGEG
     DQAHGEQGKE QAMFDKKVQL QRMVDQRSVI SDEKKVALLY LDNEEEENDG HWF
//