ID A0A2K6C8B4_MACNE Unreviewed; 570 AA.
AC A0A2K6C8B4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=PX domain containing serine/threonine kinase like {ECO:0000313|Ensembl:ENSMNEP00000019894.1};
GN Name=PXK {ECO:0000313|Ensembl:ENSMNEP00000019894.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000019894.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000019894.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A2K6C8B4; -.
DR Ensembl; ENSMNET00000044136.1; ENSMNEP00000019894.1; ENSMNEG00000033433.1.
DR GeneTree; ENSGT00390000017669; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000033433; Expressed in adult mammalian kidney and 12 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR CDD; cd06871; PX_MONaKA; 1.
DR CDD; cd22062; WH2_DdVASP-like; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR037903; MONaKA_PX.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR003124; WH2_dom.
DR PANTHER; PTHR22999:SF40; PX DOMAIN-CONTAINING PROTEIN KINASE-LIKE PROTEIN; 1.
DR PANTHER; PTHR22999; PX SERINE/THREONINE KINASE PXK; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF02205; WH2; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS51082; WH2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000233120}.
FT DOMAIN 1..118
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT DOMAIN 80..473
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 540..559
FT /note="WH2"
FT /evidence="ECO:0000259|PROSITE:PS51082"
FT REGION 429..535
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 550..570
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 429..452
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 469..490
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 491..523
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 570 AA; 63985 MW; 610B13A2A2D4AEAB CRC64;
MAFMEKPPAG KVLLDDTVPL TAAIEASQSL QSHTEYIIRV QRGISVENSW QVSIFFFFFI
AGLSLPLPPK KLIGNMDREF IAERQKGLQN YLNVITTNHI LSNCELVKKF LDPNNYSANY
TEIALQQVSM FFRSEPKWEV VEPLKDIGWR IRKKYFLMKI KNQPKERLVL SWADLGPDKY
LSDKDFQCLI KLLPSCLHPY IYRVTFATAN ESSALLIRMF NEKGTLKDLI YKAKPKDPFL
KKYCNPKKIQ GLELQQIKTY GRQILEVLKF LHDKGFPYGH LHASNVMLDG DTCRLLDLEN
SLLGLPAFYR SYFSQFRKIN TLESVDVHCF GHLLYEMTYG RPPDSVPVDS FPPAPSMAVV
AVLESTLSCE ACKNGMPTVS RLLQMPLFSD VLLTTSEKPQ FKIPTKLKEA LRIAKECIEK
RLIEEQKQIH QHRRLARAQS HHGSEEERKK RKILARKKSK RSALENSEEH SAKYNNSNNS
AGSGASSPLT SPSSPTPPST SGISALPPPP PPPPPPAAPL PPASTEAPAQ LSSQAVNGVS
RGALLSSIQN FQKGTLRKAK TCDHSAPKIG
//
