ID A0A2K6C8C1_MACNE Unreviewed; 917 AA.
AC A0A2K6C8C1;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Rho guanine nucleotide exchange factor 33 {ECO:0000313|Ensembl:ENSMNEP00000019897.1};
GN Name=ARHGEF33 {ECO:0000313|Ensembl:ENSMNEP00000019897.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000019897.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000019897.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A2K6C8C1; -.
DR STRING; 9545.ENSMNEP00000019897; -.
DR Ensembl; ENSMNET00000044139.1; ENSMNEP00000019897.1; ENSMNEG00000033776.1.
DR GeneTree; ENSGT00940000162759; -.
DR OMA; LEHANMV; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000033776; Expressed in cerebellum and 3 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR InterPro; IPR042849; ARHGEF33.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR PANTHER; PTHR46944; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 33; 1.
DR PANTHER; PTHR46944:SF1; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 33; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120}.
FT DOMAIN 313..488
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 149..190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 217..237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 545..589
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 716..917
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 53..80
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 151..176
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 565..580
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 824..850
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 873..887
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 917 AA; 102784 MW; 1B5BE6166FD9D854 CRC64;
MEKTKTKQGE NEHMPVNNPS TQIYQASKYK SSLNLPPVGA RLQRQDGGII TSLEQLHEKI
NEMRNVFNSL ENKLQALASE LKTGFTEAMQ ELSRIQHGEY ALEEKVKSCR CSMEEKVTEM
KNSLNYFKEE LSNAMSMIQA ITSKQEEMQQ KIEQLQQEKR RESRKVKAKK TQKEEHSSQA
GPAQAQGSPF RSINIPEPVL PSEDFTNLLP SQAYEKAQES RSVHVGDSNV KGMMGPGVNP
TTPEAEENLK SCLSADIQSK GHLPSGMWRQ PKDGKEWGEE YVTKDHPDKL KEAGQGRHSS
LETVLCETSL AAKRQTVALE LLESERKYVI NISLILKIKA TFQGSDGKRN SKERSLFPGS
LRYLVQQHLD LLHALQERVL KWPRQGVLGD LFLKLTNDEN NFLDYYVAYL RDLPECISLV
HVVVLKEGDE EIKSDIYTLF FHIVQRIPEY LIHLQNVLKF TEQEHPDYYL LLVCVQRLRV
FISHYTLLFQ CNEDLLIQKR KKLKKSSMAK LYKGLASQCA NAGQDASPTA GPEVVRDTGI
HSEEMLQPYP SAPSSGPAVT HLMPPVKKSQ QQQSLMESMQ PGKPSDWELE GRKHERPESL
LAPTQFCAAE QDVKALAGPL QAIPEMDFEP SPAEPLGNVE RSLRAPAELL PDARGFVPAA
YEEFEYGGEI FALPAPYDEE PFQAPALFEN CSPASSESSL DICFLRPVSF AMEAERPEHP
LQPLPKSATS PAGSSSAYKL EAAAQAQAHG KAKPLSRSLK EFPRAPPADG VAPRLYSTRS
SSGGRAPIKA ERAAQPHGPA AAAVAARGAP RTFFPQQRSQ SEKQTYLEEM HLEDTTRFCP
KEERESEQTS FSDQNPRQDQ KGGFRSSFRK LFKKKSSGSE YREKTNENPS MDPSPTKQDF
FRNRLALAND LDQGTAV
//
