ID A0A2K6C8M7_MACNE Unreviewed; 4377 AA.
AC A0A2K6C8M7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Dynein axonemal heavy chain 10 {ECO:0000313|Ensembl:ENSMNEP00000020018.1};
GN Name=DNAH10 {ECO:0000313|Ensembl:ENSMNEP00000020018.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000020018.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000020018.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR STRING; 9545.ENSMNEP00000020018; -.
DR Ensembl; ENSMNET00000044262.1; ENSMNEP00000020018.1; ENSMNEG00000033824.1.
DR GeneTree; ENSGT00940000154642; -.
DR OMA; LHCHFGE; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000033824; Expressed in multicellular organism.
DR GO; GO:0097729; C:9+2 motile cilium; IEA:UniProt.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10676:SF343; DYNEIN AXONEMAL HEAVY CHAIN 10; 1.
DR PANTHER; PTHR10676; DYNEIN HEAVY CHAIN FAMILY PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 2.
DR Pfam; PF08393; DHC_N2; 2.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120}.
FT DOMAIN 1737..1874
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2009..2157
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2351..2504
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 2953..3019
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3167..3229
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4377 AA; 503504 MW; 351B68AC353E3800 CRC64;
MDDLRVLWMR DRVYAAFGIT DPQLFEDLIN RDDGQGEDLI LHFLNQASEE EGSSALFIYR
TMVPEEVEVE IDEIPVLSAE EEEEEEIYSQ KVESVDKGRG VYLILGSLGA WMYHKNECFL
FLIFQRIVKH IVEKMHLHML CAPLPTEFLD QNVVFFLRNT KDAISEATDM KEAMEIMPET
LEYGIINANV LHFLKDIMCQ VNMEKGRNST ISEVELIFVV LVEMGFHHVG EIKLEMPTIS
VEGEVSDLAA DPETVDILEQ CVINWLNQIS IAVEGQLKKT PQGKGPLAEI EFWRERNATL
SALHEQTKLP IVRKVLDVIK ESDSMLVANL QPVFTELFKL HTEASDNVRF LSTVERYFKN
ITHGSGFHVV LDTIPAMMSA LRMVWIISRH YNKDERMIPL MERIAWEIAE RVCRVVNLRT
LFKENRASAQ NKTLDARNTL KLWKKAYFDT RAKIEASGRE ARWEFDRKRL FERTDYMATI
CQDLSDILQV LEEFYNIFGP ELKAVTGDPK RIDDVLCRVD GLVTPMENLT FDPFSIKSSQ
FWKYVMDEFK IEVLASDPSI ESILGVKQKY LEVGKTMKEY EDRKYEQWME ATEQVLPALM
KKSLLTKSST AAEEPLTLER GAVFAINFSP ALREIINETK YLEQLGFTVP ELARNVALQE
DKFLRYTDGI QRMLDHYHTL IGTLNEAESV LLNDHSQELL RVFRSGYKRL NWNSLGIGDY
ITGCKQAIGK FESLVHQIHK NADDISSRLT LIEAINLFKY PAAKSEEELP GVKEFFEHIE
RERARDVDHM VRWYLAIGPL LTKVEGLVVH TNTGKAPRLA SYYEYWEKKI YEVLTKLILK
NLQSFNSLIL GNVPLFQTET ILTAPEIILH PNTNEIDKMC FHCVRNCVEI TKHFVRWMNG
SCIECPPQKG EEEEVVIINF YNDISLNPQI IEQAVMIPQN VHRILINLMK YLQKWKRYRP
LWKLDKAIVM EKFASKKPPC VAYDEKLQFY SKIAYEVMRH PLIKDEHCIR LQLGHLANTV
QENAKSWVIS LGKLLNESAK EELYSLHEEM EHLAKSLRKI PNTLEDLKFV LATIAEIKSK
SLVMELRYRD VQERYRTMAM YNLFPPDAEK ELADKIESTW SNLFNDSVNV EHALGDIKRT
FTEITRGEIM NYRVQIEDFA KRFYSEGPGS VGDDLDKGVE LLGVFERELA RHEKSRQELA
NAEKLFDLPI TMYPELLKVQ KEMSGLRMIY ELYEGLKVAK EEWSQTLWIN LNVQILQEGI
EGFLRALRKL PRSVRGLSVA YYLEAKMKAF KDSIPLLLDL KHEALRDRHW KELMEKTSVF
FEMTETFTLE NMFAMELHKH TDVLNEIVTA AIKEVAIEKA VKEILDTWEN MKFTVVKYYK
GTQERGYILG SVDEIIQSLD DNTFNLQSIS GSRFVGPFLQ TVHKWEKTLS LIGEVIEIWM
LVQRKWMYLE SIFIGGDIRS QLPEEAKKFD NIDRVFKRMG PCFVAQPRVS ELSAGLTGPP
LPVLQMYDNI ASLRFNDGDS GEKLVSAMIS AEGEVMELRK IVRAEGRVED WMTAVLNEMR
RTNRLITKEA IFRYCEDRSR VDWMLLYQGM VVLAASQVWW TWEVEDVFHK VRKGEKQAMK
NYGRKMHRQI DELVTRITMP LSKNDRKKYN TVLIIDVHAR DIVDSFIRGS ILEAREFEWE
SQLRFYWDRE PDELNIRQCT GTFGYGYEYM GLNGRLVITP LTDRIYLTLT QALSMYLGGA
PAGPAGTGKT ETTKDLAKAL GLLCVVTNCG EGMDYKAVGK IFSGLAQCGA WGCFDEFNRI
DASVLSVISS QIQTIRNALI HQLTTFQFEG QEISLDSRMG IFITMNPGYA GRTELPESVK
ALFRPVVVIV PDMQQICEIM LFSEGFLGAK TLAKKMTVLY KLAREQLSKQ YHYDFGLRAL
KSVLVMAGEL KRGSSDLREV GATCRNILWF QLVHVHLLCA FREGNDCGCF YMDFKEKVQS
MLFYHVLAQL PLFVPQVDKV VQMFETMLTR HTTMVVGPTR GGKSVVINTL CQAQTKLGLM
TKLYILNPKA VSVIELYGIL DPTTRDWTDG VLSNIFREIN RPTDKKERKY ILFDGDVDAL
WVENMNSVMD DNKLLTLANG ERIRLQAHCA LLFEVGDLQY ASPATVSRCG MVYVDPKNLK
YRPYWEKWVN QIPNKVEQYN LNSLFEKYVP YLVDVIVEGI VDGRQTEKLK TIVPQTDLNM
VTQLAKMLDA LLEGEIEDLD LLECYFLEAL YCSLGASLLE DGRMKFDEYI KRLASLSTAD
TEGVWANPGE LPGQLPTLYD FHFDDKRNQW VPWSKLVPEY IHAPERKFID ILVHTVDTTR
STWILEQMVK IKQPVIFVGE SGTSKTATTQ NFLKNLSEET NIVLMVNFSS RTTSMDIQRN
LEANVEKRTK DTYGPPMGKR LLVFMDDMNM PRVDEYGTQQ PVALLKLLLE KGYLYDRGKE
LNCKSIRDLG FIAAMGKAGG GRNEVDPRFI SLFSVFNVPF PSEESLHLIY SSILKGHTST
FHESIVAVSG KLTFCTLALY KIIVQDLPPT PSKFHYIFNL RDLSRVFNGL VLTNPERFQT
VAQMVRVWRN ECLRVFHDRL ISETDKQLVQ QHLGDLVTEH FNDDVEVVMR DPILFGDFRM
ALHEGEPRIY EDIQDYEAAK ALFQEILEEY NESNTKMNLV LFDDALEHLT RVHRIIRMDR
GHALLVGVGG SGKQSLSRLA AFTAGCEVFE ILLSRGYSEN NFREDLKSLY LKLGIENKAM
IFLFTDAHVA EEGFLELINN MLTSGIVPAL FPEEEKESIL SQIGQEALKQ GMGPAKESVW
QYFVNKSANN LHIVLGMSPV GDTLRTWCRN FPGMVNNTGI DWFMPWPPQA LHAVAKSFLG
KSYNPMIPAE NIENVVKHVV LVHQSVGHYS KQFLQKLRRS NYVTPKNYLD FIHTYSKLLD
EKTQYNIAQC KRLDGGLDKL KEATIQLDEL NQKLAEQKIV LAEKSAACEA LLEEIAVNTA
VAEEKKKLAE EKAIEIEEQN KVIAMEKAEA ETTLEEVMPI LEAAKLELQK LDKSDVTEIR
SFAKPPKQVQ TVCECILIMK GYKELNWKTA KGMMSDPNFL RSLMEIDFDS ITQSQVKNIK
GLLKTLNTTT EEMEAVSKAG LGMLKFVEAV MGYCDVFREI KPKREKVARL ERNFYLTKRE
LERIQNELAA IQKELETLGA KYEAAILEKQ KLQEEAEIME RRLIAADKLI SGLGSENIRW
LNDLDELMHR RVKLLGDCLL CAAFLSYEGA FTWEFRDEMV NRIWQNDILE REIPLSQPFR
LESLLTDDVE ISRWGSQGLP PDELSVQNGI LTTRASRFPL CIDPQQQALN WIKRKEEKNN
LRVASFNDPD FLKQLEMSIK YGTPFLFRDV DEYIDPVIDN VLEKNIKVSQ GRQFIILGDK
EVDYDSNFRL YLNTKLANPR YTPSVFGKAM VINYTVTLKG LEDQLLSVLV AYERRELEEQ
REHLIQETSE NKNLLKDLED SLLRELATST GNMLDNVDLV HTLEETKSKA TEVSEKLKLA
EKTALDIDRL RDGYRPAARR GAILFFVLSE MALVNSMYQY SLIAFLEVFG LSLKKSLPDS
ILMKRLRNIM DTLTFNIYNY GCTGLFERHK LLFSFNMTIK IEQAEGRVPQ EELDFFLKGN
ISLEKSRRKK PCAWLSDQGW EDIILLSEMF SDSFGRLPDD VENNQTVWQE WYDLDSLEQF
PFPLGYDNNI TPFQKLLILR CFRVDRVYRA VTDYVTVTMG EKYVQPPMIS FEAIFEQSTP
NSPIVFILSP GSDPASDLMK LAERSGFGGN RLKFLAMGQG QEKVALQLLE TAVARGQWLM
LQNCHLLVKW LKDLEKSLER ITKPHPDFRL WLTTDPTKGF PIGILQKSLK VVTEPPNGLK
LNMRATYFKI SHEMLDQCPH PAFKPLVYVL AFFHAVVQER RKFGKIGWNV YYDFNESDFQ
VCMEILNTYL TKAFQQRDPR IPWGSLKYLI GEVMYGGRAI DSFDRRILTI YMDEYLGDFI
FDTFQPFHFF WNKEVDYKIP VGDEKEKFVE AIEALPLANT PEVFGLHSNA EIGYYTQAAR
DMWAHLLELQ PQTGESSSGI SRDDYIGQVA KDIENKMPKV FDLDQVRKRL GTGISPTSVV
LLQELERFNK LVVRMTKSLA ELQRALAGEV GMSNELDDVA RSLFIGQIPN IWRRLAPDTL
KSLGNWMVYF LRRFSQYMLW VTEGEPSVMW LSGLHIPESY LTALVQATCR KNGWPLDRST
LFTQVTKFQD ADEVNERAGQ GCFVSGLYLE GADWDIEKGC LIKSKPKVLV VDLPILKIIP
IEAHRLKLQN TFRTPVYTTS MRRNAMGVGL VFEADLFTTR HISHWVLQGV CLTLNSD
//
